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A kaleidoscopic view of the Arabidopsis core cell cycle interactome

Jelle Van Leene (UGent) , Joanna Boruc (UGent) , Geert De Jaeger (UGent) , Eugenia Russinova (UGent) and Lieven De Veylder (UGent)
(2011) TRENDS IN PLANT SCIENCE. 16(3). p.141-150
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Abstract
Although protein protein interaction (PPI) networks have been shown to offer a systems-wide view of cellular processes, only a few plant PPI maps are available. Recently, the core cell cycle of Arabidopsis thaliana has been analyzed by three independent PPI technologies, including yeast two-hybrid systems, bimolecular fluorescence complementation and tandem affinity purification. Here, we merge the three interactomes with literature-curated and computationally predicted interactions, paving the way for a comprehensive picture of the plant core cell cycle machinery. Platform-specific interactions unveil the strengths and weaknesses of each detection method and give insights into the nature of the interactions among cell cycle proteins. Moreover, comparison of the obtained data reveals that a complete interactome can only be obtained when multiple techniques are applied in parallel.
Keywords
DEPENDENT-KINASE, TRANSCRIPTION FACTOR, PLANT-SYSTEMS BIOLOGY, TANDEM AFFINITY PURIFICATION, A-TYPE CYCLIN, GENOME-WIDE ANALYSIS, PROTEIN-PROTEIN INTERACTIONS, KINASE-ACTIVATING KINASES, ENDOREDUPLICATION CYCLE, RETINOBLASTOMA PROTEIN

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Chicago
Van Leene, Jelle, Joanna Boruc, Geert De Jaeger, Eugenia Russinova, and Lieven De Veylder. 2011. “A Kaleidoscopic View of the Arabidopsis Core Cell Cycle Interactome.” Trends in Plant Science 16 (3): 141–150.
APA
Van Leene, J., Boruc, J., De Jaeger, G., Russinova, E., & De Veylder, L. (2011). A kaleidoscopic view of the Arabidopsis core cell cycle interactome. TRENDS IN PLANT SCIENCE, 16(3), 141–150.
Vancouver
1.
Van Leene J, Boruc J, De Jaeger G, Russinova E, De Veylder L. A kaleidoscopic view of the Arabidopsis core cell cycle interactome. TRENDS IN PLANT SCIENCE. 2011;16(3):141–50.
MLA
Van Leene, Jelle, Joanna Boruc, Geert De Jaeger, et al. “A Kaleidoscopic View of the Arabidopsis Core Cell Cycle Interactome.” TRENDS IN PLANT SCIENCE 16.3 (2011): 141–150. Print.
@article{1213363,
  abstract     = {Although protein protein interaction (PPI) networks have been shown to offer a systems-wide view of cellular processes, only a few plant PPI maps are available. Recently, the core cell cycle of Arabidopsis thaliana has been analyzed by three independent PPI technologies, including yeast two-hybrid systems, bimolecular fluorescence complementation and tandem affinity purification. Here, we merge the three interactomes with literature-curated and computationally predicted interactions, paving the way for a comprehensive picture of the plant core cell cycle machinery. Platform-specific interactions unveil the strengths and weaknesses of each detection method and give insights into the nature of the interactions among cell cycle proteins. Moreover, comparison of the obtained data reveals that a complete interactome can only be obtained when multiple techniques are applied in parallel.},
  author       = {Van Leene, Jelle and Boruc, Joanna and De Jaeger, Geert and Russinova, Eugenia and De Veylder, Lieven},
  issn         = {1360-1385},
  journal      = {TRENDS IN PLANT SCIENCE},
  keywords     = {DEPENDENT-KINASE,TRANSCRIPTION FACTOR,PLANT-SYSTEMS BIOLOGY,TANDEM AFFINITY PURIFICATION,A-TYPE CYCLIN,GENOME-WIDE ANALYSIS,PROTEIN-PROTEIN INTERACTIONS,KINASE-ACTIVATING KINASES,ENDOREDUPLICATION CYCLE,RETINOBLASTOMA PROTEIN},
  language     = {eng},
  number       = {3},
  pages        = {141--150},
  title        = {A kaleidoscopic view of the Arabidopsis core cell cycle interactome},
  url          = {http://dx.doi.org/10.1016/j.tplants.2010.12.004},
  volume       = {16},
  year         = {2011},
}

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