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Cytokinesis-blocked micronucleus assay and cancer risk assessment

Randa El-Zein, Anne Vral UGent and Carol J. Etzel (2011) MUTAGENESIS. 26(1). p.101-106
abstract
Cancer risk assessment is a multidisciplinary process that goes beyond the scope of classical epidemiology to include the biological evaluation of individual differences to carcinogenic exposures. The inclusion of genetic biomarkers such as mutagen sensitivity or cytokinesis-blocked micronucleus (CBMN) assay end points into risk assessment models allows for a more comprehensive determination of cancer risk that includes known demographic (age and gender), lifestyle exposures (smoking and alcohol) and occupational or environmental exposures. The CBMN assay generates multiple correlated end points that, after applying data reduction methods, could be combined into a summary measure that incorporates information from each individual variable into a single (or possible multiple, uncorrelated) measure of risk. In this article, we highlight the use of the CBMN assay in radiosensitivity assessment. In addition, we demonstrate the potential use of the combined summary measures in cancer risk assessment as a result of chronic exposure to tobacco carcinogens. The simplicity, rapidity and sensitivity of the CBMN assay not only make it a valuable tool for screening but also the multiple end points simultaneously generated lead to a better understanding of the underlying mechanisms involved in the carcinogenic process that could in turn substantially improve risk predictions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
STRAND BREAK REPAIR, TOBACCO-SPECIFIC NITROSAMINES, PERIPHERAL-BLOOD LYMPHOCYTES, SISTER-CHROMATID EXCHANGES, END-JOINING GENES, LUNG-CANCER, CHROMOSOMAL RADIOSENSITIVITY, BRCA1 MUTATION, MUTAGEN SENSITIVITY, CYTOME ASSAY
journal title
MUTAGENESIS
Mutagenesis
volume
26
issue
1
pages
101 - 106
Web of Science type
Review
Web of Science id
000285627700015
JCR category
TOXICOLOGY
JCR impact factor
3.183 (2011)
JCR rank
21/83 (2011)
JCR quartile
2 (2011)
ISSN
0267-8357
DOI
10.1093/mutage/geq071
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1212299
handle
http://hdl.handle.net/1854/LU-1212299
date created
2011-04-26 13:46:27
date last changed
2011-05-02 16:08:55
@article{1212299,
  abstract     = {Cancer risk assessment is a multidisciplinary process that goes beyond the scope of classical epidemiology to include the biological evaluation of individual differences to carcinogenic exposures. The inclusion of genetic biomarkers such as mutagen sensitivity or cytokinesis-blocked micronucleus (CBMN) assay end points into risk assessment models allows for a more comprehensive determination of cancer risk that includes known demographic (age and gender), lifestyle exposures (smoking and alcohol) and occupational or environmental exposures. The CBMN assay generates multiple correlated end points that, after applying data reduction methods, could be combined into a summary measure that incorporates information from each individual variable into a single (or possible multiple, uncorrelated) measure of risk. In this article, we highlight the use of the CBMN assay in radiosensitivity assessment. In addition, we demonstrate the potential use of the combined summary measures in cancer risk assessment as a result of chronic exposure to tobacco carcinogens. The simplicity, rapidity and sensitivity of the CBMN assay not only make it a valuable tool for screening but also the multiple end points simultaneously generated lead to a better understanding of the underlying mechanisms involved in the carcinogenic process that could in turn substantially improve risk predictions.},
  author       = {El-Zein, Randa and Vral, Anne and Etzel, Carol J.},
  issn         = {0267-8357},
  journal      = {MUTAGENESIS},
  keyword      = {STRAND BREAK REPAIR,TOBACCO-SPECIFIC NITROSAMINES,PERIPHERAL-BLOOD LYMPHOCYTES,SISTER-CHROMATID EXCHANGES,END-JOINING GENES,LUNG-CANCER,CHROMOSOMAL RADIOSENSITIVITY,BRCA1 MUTATION,MUTAGEN SENSITIVITY,CYTOME ASSAY},
  language     = {eng},
  number       = {1},
  pages        = {101--106},
  title        = {Cytokinesis-blocked micronucleus assay and cancer risk assessment},
  url          = {http://dx.doi.org/10.1093/mutage/geq071},
  volume       = {26},
  year         = {2011},
}

Chicago
El-Zein, Randa, Anne Vral, and Carol J. Etzel. 2011. “Cytokinesis-blocked Micronucleus Assay and Cancer Risk Assessment.” Mutagenesis 26 (1): 101–106.
APA
El-Zein, R., Vral, A., & Etzel, C. J. (2011). Cytokinesis-blocked micronucleus assay and cancer risk assessment. MUTAGENESIS, 26(1), 101–106.
Vancouver
1.
El-Zein R, Vral A, Etzel CJ. Cytokinesis-blocked micronucleus assay and cancer risk assessment. MUTAGENESIS. 2011;26(1):101–6.
MLA
El-Zein, Randa, Anne Vral, and Carol J. Etzel. “Cytokinesis-blocked Micronucleus Assay and Cancer Risk Assessment.” MUTAGENESIS 26.1 (2011): 101–106. Print.