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The impact of HF-rTMS treatment on serotonin2A receptors in unipolar melancholic depression

Chris Baeken UGent, Rudi De Raedt UGent, Axel Bossuyt, Christian Vanhove UGent, John Mertens, André Dobbeleir, PETER BLANCKAERT UGent and Ingeborg Goethals UGent (2011) BRAIN STIMULATION. 4(2). p.104-111
abstract
Background: Currently, the underlying neurobiological mechanism as to how repetitive transcranial magnetic stimulation (rTMS) can alter depressive states remains unclear. Animal data suggest that its influence could occur at the neurotransmitter level, such as modulation of the serotonin system. Methods: Twenty-one antidepressant-free medication-resistant unipolar depressed patients, and 21 age- and gender-matched healthy subjects were studied. We examined the neurobiologic impact of 10 high-frequent (HF)-rTMS sessions applied to the left dorsolateral prefrontal cortex (DLPFC) on postsynaptic 5-HT2A receptor binding indices (BI) measured with 123I-5-I-R91150 single photon emission computed tomography (SPECT) only in patients. Results: Compared with the control group, patients displayed significantly less bilateral dorsolateral prefrontal cortical and significantly higher left hippocampal baseline 5-HT2A receptor BI. Successful HF-rTMS treatment correlated positively with 5-HT2A receptor BI in the DLPFC bilaterally and correlated negatively with right hippocampal 5-HT2A receptor uptake values. Conclusions: Our results indicate that HF-rTMS treatment affect the serotonergic system. Our data also suggest that this kind of treatment affects 5-HT2A receptor BI in the DLPFC and in the hippocampus in different ways.
Please use this url to cite or link to this publication:
author
organization
alternative title
The impact of HF-rTMS treatment on serotonin(2A) receptors in unipolar melancholic depression
year
type
journalArticle (original)
publication status
published
subject
keyword
major depression, melancholia, SPECT, 5-HT2A receptor, treatment resistance, serotonin, HF-rTMS, TRANSCRANIAL MAGNETIC STIMULATION, DORSOLATERAL PREFRONTAL CORTEX, POSITRON-EMISSION-TOMOGRAPHY, 5-HT2A RECEPTORS, MAJOR DEPRESSION, NEUROTROPHIC FACTOR, RAT-BRAIN, HEALTHY-VOLUNTEERS, ELECTROCONVULSIVE SHOCK, MESSENGER-RNA
journal title
BRAIN STIMULATION
Brain Stimul.
volume
4
issue
2
pages
104 - 111
Web of Science type
Article
Web of Science id
000290191100007
JCR category
CLINICAL NEUROLOGY
JCR impact factor
3.755 (2011)
JCR rank
36/190 (2011)
JCR quartile
1 (2011)
ISSN
1935-861X
DOI
10.1016/j.brs.2010.09.002
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1212183
handle
http://hdl.handle.net/1854/LU-1212183
date created
2011-04-26 10:21:46
date last changed
2013-02-27 09:19:02
@article{1212183,
  abstract     = {Background: Currently, the underlying neurobiological mechanism as to how repetitive transcranial magnetic stimulation (rTMS) can alter depressive states remains unclear. Animal data suggest that its influence could occur at the neurotransmitter level, such as modulation of the serotonin system.
Methods: Twenty-one antidepressant-free medication-resistant unipolar depressed patients, and 21 age- and gender-matched healthy subjects were studied. We examined the neurobiologic impact of 10 high-frequent (HF)-rTMS sessions applied to the left dorsolateral prefrontal cortex (DLPFC) on postsynaptic 5-HT2A receptor binding indices (BI) measured with 123I-5-I-R91150 single photon emission computed tomography (SPECT) only in patients.
Results: Compared with the control group, patients displayed significantly less bilateral dorsolateral prefrontal cortical and significantly higher left hippocampal baseline 5-HT2A receptor BI. Successful HF-rTMS treatment correlated positively with 5-HT2A receptor BI in the DLPFC bilaterally and correlated negatively with right hippocampal 5-HT2A receptor uptake values.
Conclusions: Our results indicate that HF-rTMS treatment affect the serotonergic system. Our data also suggest that this kind of treatment affects 5-HT2A receptor BI in the DLPFC and in the hippocampus in different ways.},
  author       = {Baeken, Chris and De Raedt, Rudi and Bossuyt, Axel and Vanhove, Christian and Mertens, John and Dobbeleir, Andr{\'e}  and BLANCKAERT, PETER and Goethals, Ingeborg},
  issn         = {1935-861X},
  journal      = {BRAIN STIMULATION},
  keyword      = {major depression,melancholia,SPECT,5-HT2A receptor,treatment resistance,serotonin,HF-rTMS,TRANSCRANIAL MAGNETIC STIMULATION,DORSOLATERAL PREFRONTAL CORTEX,POSITRON-EMISSION-TOMOGRAPHY,5-HT2A RECEPTORS,MAJOR DEPRESSION,NEUROTROPHIC FACTOR,RAT-BRAIN,HEALTHY-VOLUNTEERS,ELECTROCONVULSIVE SHOCK,MESSENGER-RNA},
  language     = {eng},
  number       = {2},
  pages        = {104--111},
  title        = {The impact of HF-rTMS treatment on serotonin2A receptors in unipolar melancholic depression},
  url          = {http://dx.doi.org/10.1016/j.brs.2010.09.002},
  volume       = {4},
  year         = {2011},
}

Chicago
Baeken, Chris, Rudi De Raedt, Axel Bossuyt, Christian Vanhove, John Mertens, André Dobbeleir, PETER BLANCKAERT, and Ingeborg Goethals. 2011. “The Impact of HF-rTMS Treatment on serotonin2A Receptors in Unipolar Melancholic Depression.” Brain Stimulation 4 (2): 104–111.
APA
Baeken, C., De Raedt, R., Bossuyt, A., Vanhove, C., Mertens, J., Dobbeleir, A., BLANCKAERT, P., et al. (2011). The impact of HF-rTMS treatment on serotonin2A receptors in unipolar melancholic depression. BRAIN STIMULATION, 4(2), 104–111.
Vancouver
1.
Baeken C, De Raedt R, Bossuyt A, Vanhove C, Mertens J, Dobbeleir A, et al. The impact of HF-rTMS treatment on serotonin2A receptors in unipolar melancholic depression. BRAIN STIMULATION. 2011;4(2):104–11.
MLA
Baeken, Chris, Rudi De Raedt, Axel Bossuyt, et al. “The Impact of HF-rTMS Treatment on serotonin2A Receptors in Unipolar Melancholic Depression.” BRAIN STIMULATION 4.2 (2011): 104–111. Print.