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Static secondary ion mass spectrometry for the surface characterisation of individual nanofibres of polycaprolactone functionalised with an antibacterial additive

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Center for nano- and biophotonics (NB-Photonics)
Abstract
Electrospinning (ES) of polymer solutions generates non-woven webs of nanofibres. The fibre diameter ranges between 10 nm and 1 mu m depending on the operating conditions. Surface functionalisation can be performed by the use of suitable additives. Detailed characterisation of the molecular composition at the fibre surface is a key issue. Biodegradable nanowebs with potential antibacterial activity have been prepared by ES of solutions containing polycaprolactone (PCL) and a functionalising additive with PCL segments and hexyldimethylammonium groups (PCLhexaq). Static secondary ion mass spectrometry with Bi-3(+) projectiles has been applied to individual nanofibres. The positive ion mass spectra contain several signals with high structural specificity allowing the presence of PCLhexaq to be traced back in spite of its low concentration (0.16-1.4% w/w relative to PCL) and its structural similarity to the PCL fibre matrix. Imaging of structural ions visualises the homogeneous distribution of PCLhexaq over the fibre surface. Quantifying the surface concentration of PCLhexaq relative to that of PCL reveals electric field-driven surface enrichment of the additive during ES. Finally, nanofibres subjected to leaching in water for up to 72 h have been analysed. The PCLhexaq surface concentration decreases almost linearly with time at a rate of 0.6% h(-1).
Keywords
Electrospinning, Polycaprolactone, Leaching, Nanofibres, Static secondary ion mass spectrometry, Biomaterials, FIELD, FIBERS, SIMS

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Citation

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Chicago
Van Royen, Pieter, Bart Boschmans, Ana Do Amaral Cardoso dos Santos, Etienne Schacht, Peter Dubruel, Maria Cornelissen, Linda Beenaerts, and Luc Van Vaeck. 2011. “Static Secondary Ion Mass Spectrometry for the Surface Characterisation of Individual Nanofibres of Polycaprolactone Functionalised with an Antibacterial Additive.” Analytical and Bioanalytical Chemistry 399 (3): 1163–1172.
APA
Van Royen, Pieter, Boschmans, B., Do Amaral Cardoso dos Santos, A., Schacht, E., Dubruel, P., Cornelissen, M., Beenaerts, L., et al. (2011). Static secondary ion mass spectrometry for the surface characterisation of individual nanofibres of polycaprolactone functionalised with an antibacterial additive. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 399(3), 1163–1172.
Vancouver
1.
Van Royen P, Boschmans B, Do Amaral Cardoso dos Santos A, Schacht E, Dubruel P, Cornelissen M, et al. Static secondary ion mass spectrometry for the surface characterisation of individual nanofibres of polycaprolactone functionalised with an antibacterial additive. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2011;399(3):1163–72.
MLA
Van Royen, Pieter, Bart Boschmans, Ana Do Amaral Cardoso dos Santos, et al. “Static Secondary Ion Mass Spectrometry for the Surface Characterisation of Individual Nanofibres of Polycaprolactone Functionalised with an Antibacterial Additive.” ANALYTICAL AND BIOANALYTICAL CHEMISTRY 399.3 (2011): 1163–1172. Print.
@article{1211711,
  abstract     = {Electrospinning (ES) of polymer solutions generates non-woven webs of nanofibres. The fibre diameter ranges between 10 nm and 1 mu m depending on the operating conditions. Surface functionalisation can be performed by the use of suitable additives. Detailed characterisation of the molecular composition at the fibre surface is a key issue. Biodegradable nanowebs with potential antibacterial activity have been prepared by ES of solutions containing polycaprolactone (PCL) and a functionalising additive with PCL segments and hexyldimethylammonium groups (PCLhexaq). Static secondary ion mass spectrometry with Bi-3(+) projectiles has been applied to individual nanofibres. The positive ion mass spectra contain several signals with high structural specificity allowing the presence of PCLhexaq to be traced back in spite of its low concentration (0.16-1.4% w/w relative to PCL) and its structural similarity to the PCL fibre matrix. Imaging of structural ions visualises the homogeneous distribution of PCLhexaq over the fibre surface. Quantifying the surface concentration of PCLhexaq relative to that of PCL reveals electric field-driven surface enrichment of the additive during ES. Finally, nanofibres subjected to leaching in water for up to 72 h have been analysed. The PCLhexaq surface concentration decreases almost linearly with time at a rate of 0.6% h(-1).},
  author       = {Van Royen, Pieter and Boschmans, Bart and Do Amaral Cardoso dos Santos, Ana and Schacht, Etienne and Dubruel, Peter and Cornelissen, Maria and Beenaerts, Linda and Van Vaeck, Luc},
  issn         = {1618-2642},
  journal      = {ANALYTICAL AND BIOANALYTICAL CHEMISTRY},
  keywords     = {Electrospinning,Polycaprolactone,Leaching,Nanofibres,Static secondary ion mass spectrometry,Biomaterials,FIELD,FIBERS,SIMS},
  language     = {eng},
  number       = {3},
  pages        = {1163--1172},
  title        = {Static secondary ion mass spectrometry for the surface characterisation of individual nanofibres of polycaprolactone functionalised with an antibacterial additive},
  url          = {http://dx.doi.org/10.1007/s00216-010-4433-x},
  volume       = {399},
  year         = {2011},
}

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