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Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report

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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
This pilot study was designed to describe the technical details and to present the preliminary outcome of autologous matrix-induced chondrogenesis (AMIC) combined with platelet-rich plasma gel, the so called AMIC plus technique, for the treatment of patellar cartilage defects in the knee. The AMIC plus technique was used for the treatment of (osteo) chondral patellar lesions in the knee. The surgical technique is extensively described. Five patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) and modified MOCART scoring system. A clinical improvement became apparent after 24 months of follow-up. Both MOCART scoring systems revealed no significant deterioration or improvement of the repair tissue between one and 2 years of follow-up. However, all cases showed subchondral lamina and bone changes. The formation of intralesional osteophytes was observed in 3 of the 5 patients during the 2 years of follow-up. AMIC plus is feasible for the treatment of symptomatic patellar cartilage defects and resulted in a clinical improvement in all patients. The favourable clinical outcome of the AMIC plus technique was not confirmed by the MRI findings.
Keywords
ARTICULAR-CARTILAGE DEFECTS, Cartilage, Knee, PRP, AMIC, THICKNESS CHONDRAL DEFECTS, VISUAL ANALOG SCALE, OUTCOME SCORE KOOS, CHONDROCYTE IMPLANTATION, REPAIR TISSUE, KNEE INJURY, TRANSPLANTATION, OSTEOARTHRITIS, MICROFRACTURE

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Citation

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Chicago
Dhollander, Aad, Francis De Neve, Karl Almqvist, René Verdonk, Stijn Lambrecht, Dirk Elewaut, August Verbruggen, and Peter Verdonk. 2011. “Autologous Matrix-induced Chondrogenesis Combined with Platelet-rich Plasma Gel: Technical Description and a Five Pilot Patients Report.” Knee Surgery Sports Traumatology Arthroscopy 19 (4): 536–542.
APA
Dhollander, A., De Neve, F., Almqvist, K., Verdonk, R., Lambrecht, S., Elewaut, D., Verbruggen, A., et al. (2011). Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 19(4), 536–542.
Vancouver
1.
Dhollander A, De Neve F, Almqvist K, Verdonk R, Lambrecht S, Elewaut D, et al. Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 2011;19(4):536–42.
MLA
Dhollander, Aad, Francis De Neve, Karl Almqvist, et al. “Autologous Matrix-induced Chondrogenesis Combined with Platelet-rich Plasma Gel: Technical Description and a Five Pilot Patients Report.” KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 19.4 (2011): 536–542. Print.
@article{1208588,
  abstract     = {This pilot study was designed to describe the technical details and to present the preliminary outcome of autologous matrix-induced chondrogenesis (AMIC) combined with platelet-rich plasma gel, the so called AMIC plus technique, for the treatment of patellar cartilage defects in the knee.
The AMIC plus technique was used for the treatment of (osteo) chondral patellar lesions in the knee. The surgical technique is extensively described. Five patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) and modified MOCART scoring system.
A clinical improvement became apparent after 24 months of follow-up. Both MOCART scoring systems revealed no significant deterioration or improvement of the repair tissue between one and 2 years of follow-up. However, all cases showed subchondral lamina and bone changes. The formation of intralesional osteophytes was observed in 3 of the 5 patients during the 2 years of follow-up.
AMIC plus is feasible for the treatment of symptomatic patellar cartilage defects and resulted in a clinical improvement in all patients. The favourable clinical outcome of the AMIC plus technique was not confirmed by the MRI findings.},
  author       = {Dhollander, Aad and De Neve, Francis and Almqvist, Karl and Verdonk, Ren{\'e} and Lambrecht, Stijn and Elewaut, Dirk and Verbruggen, August and Verdonk, Peter},
  issn         = {0942-2056},
  journal      = {KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY},
  keyword      = {ARTICULAR-CARTILAGE DEFECTS,Cartilage,Knee,PRP,AMIC,THICKNESS CHONDRAL DEFECTS,VISUAL ANALOG SCALE,OUTCOME SCORE KOOS,CHONDROCYTE IMPLANTATION,REPAIR TISSUE,KNEE INJURY,TRANSPLANTATION,OSTEOARTHRITIS,MICROFRACTURE},
  language     = {eng},
  number       = {4},
  pages        = {536--542},
  title        = {Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report},
  url          = {http://dx.doi.org/10.1007/s00167-010-1337-4},
  volume       = {19},
  year         = {2011},
}

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