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Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report

Aad Dhollander UGent, Francis De Neve UGent, Karl Almqvist UGent, René Verdonk UGent, Stijn Lambrecht UGent, Dirk Elewaut UGent, August Verbruggen UGent and Peter Verdonk UGent (2011) KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 19(4). p.536-542
abstract
This pilot study was designed to describe the technical details and to present the preliminary outcome of autologous matrix-induced chondrogenesis (AMIC) combined with platelet-rich plasma gel, the so called AMIC plus technique, for the treatment of patellar cartilage defects in the knee. The AMIC plus technique was used for the treatment of (osteo) chondral patellar lesions in the knee. The surgical technique is extensively described. Five patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) and modified MOCART scoring system. A clinical improvement became apparent after 24 months of follow-up. Both MOCART scoring systems revealed no significant deterioration or improvement of the repair tissue between one and 2 years of follow-up. However, all cases showed subchondral lamina and bone changes. The formation of intralesional osteophytes was observed in 3 of the 5 patients during the 2 years of follow-up. AMIC plus is feasible for the treatment of symptomatic patellar cartilage defects and resulted in a clinical improvement in all patients. The favourable clinical outcome of the AMIC plus technique was not confirmed by the MRI findings.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ARTICULAR-CARTILAGE DEFECTS, Cartilage, Knee, PRP, AMIC, THICKNESS CHONDRAL DEFECTS, VISUAL ANALOG SCALE, OUTCOME SCORE KOOS, CHONDROCYTE IMPLANTATION, REPAIR TISSUE, KNEE INJURY, TRANSPLANTATION, OSTEOARTHRITIS, MICROFRACTURE
journal title
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
Knee Surg. Sports Traumatol. Arthrosc.
volume
19
issue
4
pages
536 - 542
Web of Science type
Article
Web of Science id
000288668700004
JCR category
SPORT SCIENCES
JCR impact factor
2.209 (2011)
JCR rank
17/83 (2011)
JCR quartile
1 (2011)
ISSN
0942-2056
DOI
10.1007/s00167-010-1337-4
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1208588
handle
http://hdl.handle.net/1854/LU-1208588
date created
2011-04-14 09:53:36
date last changed
2013-02-27 09:08:15
@article{1208588,
  abstract     = {This pilot study was designed to describe the technical details and to present the preliminary outcome of autologous matrix-induced chondrogenesis (AMIC) combined with platelet-rich plasma gel, the so called AMIC plus technique, for the treatment of patellar cartilage defects in the knee.
The AMIC plus technique was used for the treatment of (osteo) chondral patellar lesions in the knee. The surgical technique is extensively described. Five patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) and modified MOCART scoring system.
A clinical improvement became apparent after 24 months of follow-up. Both MOCART scoring systems revealed no significant deterioration or improvement of the repair tissue between one and 2 years of follow-up. However, all cases showed subchondral lamina and bone changes. The formation of intralesional osteophytes was observed in 3 of the 5 patients during the 2 years of follow-up.
AMIC plus is feasible for the treatment of symptomatic patellar cartilage defects and resulted in a clinical improvement in all patients. The favourable clinical outcome of the AMIC plus technique was not confirmed by the MRI findings.},
  author       = {Dhollander, Aad and De Neve, Francis and Almqvist, Karl and Verdonk, Ren{\'e} and Lambrecht, Stijn and Elewaut, Dirk and Verbruggen, August and Verdonk, Peter},
  issn         = {0942-2056},
  journal      = {KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY},
  keyword      = {ARTICULAR-CARTILAGE DEFECTS,Cartilage,Knee,PRP,AMIC,THICKNESS CHONDRAL DEFECTS,VISUAL ANALOG SCALE,OUTCOME SCORE KOOS,CHONDROCYTE IMPLANTATION,REPAIR TISSUE,KNEE INJURY,TRANSPLANTATION,OSTEOARTHRITIS,MICROFRACTURE},
  language     = {eng},
  number       = {4},
  pages        = {536--542},
  title        = {Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report},
  url          = {http://dx.doi.org/10.1007/s00167-010-1337-4},
  volume       = {19},
  year         = {2011},
}

Chicago
DHOLLANDER, AAD, Francis De Neve, Karl Almqvist, René Verdonk, Stijn Lambrecht, Dirk Elewaut, August Verbruggen, and Peter Verdonk. 2011. “Autologous Matrix-induced Chondrogenesis Combined with Platelet-rich Plasma Gel: Technical Description and a Five Pilot Patients Report.” Knee Surgery Sports Traumatology Arthroscopy 19 (4): 536–542.
APA
DHOLLANDER, A., De Neve, F., Almqvist, K., Verdonk, R., Lambrecht, S., Elewaut, D., Verbruggen, A., et al. (2011). Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 19(4), 536–542.
Vancouver
1.
DHOLLANDER A, De Neve F, Almqvist K, Verdonk R, Lambrecht S, Elewaut D, et al. Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 2011;19(4):536–42.
MLA
DHOLLANDER, AAD, Francis De Neve, Karl Almqvist, et al. “Autologous Matrix-induced Chondrogenesis Combined with Platelet-rich Plasma Gel: Technical Description and a Five Pilot Patients Report.” KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 19.4 (2011): 536–542. Print.