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Emergence of tissue polarization form synergy of intracellular and extracellular auxin signaling

Krzysztof Wabnik UGent, Jürgen Kleine-Vehn UGent, Jozef Balla, Michael Sauer, Satoshi Naramoto UGent, Vilem Reinoehl, Roeland Merks UGent, Willy Govaerts UGent and Jiri Friml UGent (2010) MOLECULAR SYSTEMS BIOLOGY. 6.
abstract
Plant development is exceptionally flexible as manifested by its potential for organogenesis and regeneration, which are processes involving rearrangements of tissue polarities. Fundamental questions concern how individual cells can polarize in a coordinated manner to integrate into the multicellular context. In canalization models, the signaling molecule auxin acts as a polarizing cue, and feedback on the intercellular auxin flow is key for synchronized polarity rearrangements. We provide a novel mechanistic framework for canalization, based on up-to-date experimental data and minimal, biologically plausible assumptions. Our model combines the intracellular auxin signaling for expression of PINFORMED (PIN) auxin transporters and the theoretical postulation of extracellular auxin signaling for modulation of PIN subcellular dynamics. Computer simulations faithfully and robustly recapitulated the experimentally observed patterns of tissue polarity and asymmetric auxin distribution during formation and regeneration of vascular systems and during the competitive regulation of shoot branching by apical dominance. Additionally, our model generated new predictions that could be experimentally validated, highlighting a mechanistically conceivable explanation for the PIN polarization and canalization of the auxin flow in plants
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BOX PROTEIN TIR1, PIN proteins, cell polarity, auxin, canalization, ARABIDOPSIS-THALIANA, ROOT GRAVITROPISM, GENE-EXPRESSION, PIN PROTEINS, TRANSPORT, EFFLUX, PHYLLOTAXIS, CANALIZATION, ENDOCYTOSIS
journal title
MOLECULAR SYSTEMS BIOLOGY
Mol. Syst. Biol.
volume
6
article_number
447
pages
15 pages
Web of Science type
Article
Web of Science id
000285930400003
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
9.667 (2010)
JCR rank
19/284 (2010)
JCR quartile
1 (2010)
ISSN
1744-4292
DOI
10.1038/msb.2010.103
project
Computational methods for modelling the cell cycle as a nonlinear process
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1208429
handle
http://hdl.handle.net/1854/LU-1208429
date created
2011-04-13 16:08:48
date last changed
2012-09-19 14:04:09
@article{1208429,
  abstract     = {Plant development is exceptionally flexible as manifested by its potential for organogenesis and regeneration, which are processes involving rearrangements of tissue polarities. Fundamental questions concern how individual cells can polarize in a coordinated manner to integrate into the multicellular context. In canalization models, the signaling molecule auxin acts as a polarizing cue, and feedback on the intercellular auxin flow is key for synchronized polarity rearrangements. We provide a novel mechanistic framework for canalization, based on up-to-date experimental data and minimal, biologically plausible assumptions. Our model combines the intracellular auxin signaling for expression of PINFORMED (PIN) auxin transporters and the theoretical postulation of extracellular auxin signaling for modulation of PIN subcellular dynamics. Computer simulations faithfully and robustly recapitulated the experimentally observed patterns of tissue polarity and asymmetric auxin distribution during formation and regeneration of vascular systems and during the competitive regulation of shoot branching by apical dominance. Additionally, our model generated new predictions that could be experimentally validated, highlighting a mechanistically conceivable explanation for the PIN polarization and canalization of the auxin flow in plants},
  articleno    = {447},
  author       = {Wabnik, Krzysztof and Kleine-Vehn, J{\"u}rgen and Balla, Jozef and Sauer, Michael and Naramoto, Satoshi and Reinoehl, Vilem and Merks, Roeland and Govaerts, Willy and Friml, Jiri},
  issn         = {1744-4292},
  journal      = {MOLECULAR SYSTEMS BIOLOGY},
  keyword      = {BOX PROTEIN TIR1,PIN proteins,cell polarity,auxin,canalization,ARABIDOPSIS-THALIANA,ROOT GRAVITROPISM,GENE-EXPRESSION,PIN PROTEINS,TRANSPORT,EFFLUX,PHYLLOTAXIS,CANALIZATION,ENDOCYTOSIS},
  language     = {eng},
  pages        = {15},
  title        = {Emergence of tissue polarization form synergy of intracellular and extracellular auxin signaling},
  url          = {http://dx.doi.org/10.1038/msb.2010.103},
  volume       = {6},
  year         = {2010},
}

Chicago
Wabnik, Krzysztof, Jürgen Kleine-Vehn, Jozef Balla, Michael Sauer, Satoshi Naramoto, Vilem Reinoehl, Roeland Merks, Willy Govaerts, and Jiri Friml. 2010. “Emergence of Tissue Polarization Form Synergy of Intracellular and Extracellular Auxin Signaling.” Molecular Systems Biology 6.
APA
Wabnik, K., Kleine-Vehn, J., Balla, J., Sauer, M., Naramoto, S., Reinoehl, V., Merks, R., et al. (2010). Emergence of tissue polarization form synergy of intracellular and extracellular auxin signaling. MOLECULAR SYSTEMS BIOLOGY, 6.
Vancouver
1.
Wabnik K, Kleine-Vehn J, Balla J, Sauer M, Naramoto S, Reinoehl V, et al. Emergence of tissue polarization form synergy of intracellular and extracellular auxin signaling. MOLECULAR SYSTEMS BIOLOGY. 2010;6.
MLA
Wabnik, Krzysztof, Jürgen Kleine-Vehn, Jozef Balla, et al. “Emergence of Tissue Polarization Form Synergy of Intracellular and Extracellular Auxin Signaling.” MOLECULAR SYSTEMS BIOLOGY 6 (2010): n. pag. Print.