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Lentiviral nuclear import: a complex interplay between virus and host

Jan De rijck (UGent) , Linos Vandekerckhove (UGent) , Frauke Christ and Zeger Debyser
(2007) BIOESSAYS. 29(5). p.441-451
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Abstract
Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host.
Keywords
TYPE-1 PREINTEGRATION COMPLEXES, CELL-CYCLE ARREST, INTEGRASE INTERACTOR LEDGF/P75, CENTRAL POLYPURINE TRACT, MURINE LEUKEMIA-VIRUS, PLUS-STRAND SYNTHESIS, HIV-1 MATRIX PROTEIN, AVIAN-SARCOMA VIRUS, CENTRAL DNA FLAP, HUMAN-IMMUNODEFICIENCY-VIRUS

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Citation

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Chicago
De rijckJan, Linos Vandekerckhove, Frauke Christ, and Zeger Debyser. 2007. “Lentiviral Nuclear Import: a Complex Interplay Between Virus and Host.” Bioessays 29 (5): 441–451.
APA
De rijckJan, Vandekerckhove, L., Christ, F., & Debyser, Z. (2007). Lentiviral nuclear import: a complex interplay between virus and host. BIOESSAYS, 29(5), 441–451.
Vancouver
1.
De rijckJan, Vandekerckhove L, Christ F, Debyser Z. Lentiviral nuclear import: a complex interplay between virus and host. BIOESSAYS. 2007;29(5):441–51.
MLA
De rijckJan, Linos Vandekerckhove, Frauke Christ, et al. “Lentiviral Nuclear Import: a Complex Interplay Between Virus and Host.” BIOESSAYS 29.5 (2007): 441–451. Print.
@article{1206438,
  abstract     = {Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host.},
  author       = {De rijck, Jan and Vandekerckhove, Linos and Christ, Frauke and Debyser, Zeger},
  issn         = {0265-9247},
  journal      = {BIOESSAYS},
  keyword      = {TYPE-1 PREINTEGRATION COMPLEXES,CELL-CYCLE ARREST,INTEGRASE INTERACTOR LEDGF/P75,CENTRAL POLYPURINE TRACT,MURINE LEUKEMIA-VIRUS,PLUS-STRAND SYNTHESIS,HIV-1 MATRIX PROTEIN,AVIAN-SARCOMA VIRUS,CENTRAL DNA FLAP,HUMAN-IMMUNODEFICIENCY-VIRUS},
  language     = {eng},
  number       = {5},
  pages        = {441--451},
  title        = {Lentiviral nuclear import: a complex interplay between virus and host},
  url          = {http://dx.doi.org/10.1002/bies.20561},
  volume       = {29},
  year         = {2007},
}
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