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Lentiviral nuclear import: a complex interplay between virus and host

Jan De rijck UGent, Linos Vandekerckhove UGent, Frauke Christ and Zeger Debyser (2007) BIOESSAYS. 29(5). p.441-451
abstract
Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
TYPE-1 PREINTEGRATION COMPLEXES, CELL-CYCLE ARREST, INTEGRASE INTERACTOR LEDGF/P75, CENTRAL POLYPURINE TRACT, MURINE LEUKEMIA-VIRUS, PLUS-STRAND SYNTHESIS, HIV-1 MATRIX PROTEIN, AVIAN-SARCOMA VIRUS, CENTRAL DNA FLAP, HUMAN-IMMUNODEFICIENCY-VIRUS
journal title
BIOESSAYS
Bioessays
volume
29
issue
5
pages
441 - 451
Web of Science type
Review
Web of Science id
000246034700007
JCR category
BIOLOGY
JCR impact factor
5.402 (2007)
JCR rank
5/70 (2007)
JCR quartile
1 (2007)
ISSN
0265-9247
DOI
10.1002/bies.20561
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1206438
handle
http://hdl.handle.net/1854/LU-1206438
date created
2011-04-11 15:03:38
date last changed
2011-05-10 15:18:21
@article{1206438,
  abstract     = {Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host.},
  author       = {De rijck, Jan and Vandekerckhove, Linos and Christ, Frauke and Debyser, Zeger},
  issn         = {0265-9247},
  journal      = {BIOESSAYS},
  keyword      = {TYPE-1 PREINTEGRATION COMPLEXES,CELL-CYCLE ARREST,INTEGRASE INTERACTOR LEDGF/P75,CENTRAL POLYPURINE TRACT,MURINE LEUKEMIA-VIRUS,PLUS-STRAND SYNTHESIS,HIV-1 MATRIX PROTEIN,AVIAN-SARCOMA VIRUS,CENTRAL DNA FLAP,HUMAN-IMMUNODEFICIENCY-VIRUS},
  language     = {eng},
  number       = {5},
  pages        = {441--451},
  title        = {Lentiviral nuclear import: a complex interplay between virus and host},
  url          = {http://dx.doi.org/10.1002/bies.20561},
  volume       = {29},
  year         = {2007},
}

Chicago
De rijckJan, Linos Vandekerckhove, Frauke Christ, and Zeger Debyser. 2007. “Lentiviral Nuclear Import: a Complex Interplay Between Virus and Host.” Bioessays 29 (5): 441–451.
APA
De rijckJan, Vandekerckhove, L., Christ, F., & Debyser, Z. (2007). Lentiviral nuclear import: a complex interplay between virus and host. BIOESSAYS, 29(5), 441–451.
Vancouver
1.
De rijckJan, Vandekerckhove L, Christ F, Debyser Z. Lentiviral nuclear import: a complex interplay between virus and host. BIOESSAYS. 2007;29(5):441–51.
MLA
De rijckJan, Linos Vandekerckhove, Frauke Christ, et al. “Lentiviral Nuclear Import: a Complex Interplay Between Virus and Host.” BIOESSAYS 29.5 (2007): 441–451. Print.