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Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh

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Abstract
Objective: The study was set up to determine to what extent the addition of a supplement of vitamin A alone or in combination with zinc would improve standard iron treatment and correction of iron deficiency anaemia. Design: 216 non-pregnant anaemic women of 15-45 years of age with haemoglobin levels less than or equal to 100 g/l were randomly assigned to three treatment groups. One group (A) received iron alone, a second group (B) received iron and vitamin A, and a third group (C) received iron, vitamin A and zinc. Every woman was given one iron capsule per day for 60 days as FeSO4 containing 60 mg of elemental iron. Ln addition, groups B and C received 200 000 IU of vitamin A, given as a supervised dose, on the first day of the treatment after collection of the blood sample. Group C received one zinc tablet per day for 60 days as zinc gluconate containing 15 mg of elemental zinc. Setting: The north-western part of Bangladesh in the urban slums of Dinajpur district between February and August 1995. Subjects: To select women with a haemoglobin level of less than or equal to 100 g/l, all the women of four randomly selected municipal slums of the district in the targeted age group (328) were invited to take part in the study. Blood samples were analysed for haemoglobin, serum iron, total iron binding capacity (TIBC), ferritin, retinol and zinc. Results: Out of the 328 women screened, 254 (77.5%) had a haemoglobin level less than or equal to 100 g/l and 322 (98%) less than or equal to 120 g/l. The three treatment schedules significantly increased haemoglobin levels and improved iron parameters, except for serum iron in the group who received iron alone. The group who received iron, vitamin A and zinc responded best with an increase in haemoglobin of 17.9 g/l as compared to the group receiving iron alone (13.4 g/l). Iron and vitamin A treatment gave an intermediate response of 15.9 g/l. However, these differences are only statistically significant only for the group who received iron, vitamin A and zinc and only for the increase in haemoglobin, P = 0.03. Conclusion: The results are suggestive that the addition of vitamin A and zinc to the treatment for anaemia can increase haemoglobin levels more than with iron alone. Sponsorship: The present study was financed by grant FWO 1.5.092.96 and Nutrition Tiers Monde.
Keywords
NUTRITIONAL ANEMIA, NORTHEAST THAILAND, PREGNANT-WOMEN, A-DEFICIENCY, BREAST-MILK, WEST-JAVA, CHILDREN, METABOLISM, SERUM, TRANSFERRIN, Bangladesh, iron deficiency, vitamin A, women, zinc

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Chicago
Kolsteren, Patrick, S Rahman, K Hilderbrand, and A Diniz. 1999. “Treatment for Iron Deficiency Anaemia with a Combined Supplementation of Iron, Vitamin A and Zinc in Women of Dinajpur, Bangladesh.” European Journal of Clinical Nutrition 53 (2): 102–106.
APA
Kolsteren, P., Rahman, S., Hilderbrand, K., & Diniz, A. (1999). Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 53(2), 102–106.
Vancouver
1.
Kolsteren P, Rahman S, Hilderbrand K, Diniz A. Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh. EUROPEAN JOURNAL OF CLINICAL NUTRITION. 1999;53(2):102–6.
MLA
Kolsteren, Patrick, S Rahman, K Hilderbrand, et al. “Treatment for Iron Deficiency Anaemia with a Combined Supplementation of Iron, Vitamin A and Zinc in Women of Dinajpur, Bangladesh.” EUROPEAN JOURNAL OF CLINICAL NUTRITION 53.2 (1999): 102–106. Print.
@article{120384,
  abstract     = {Objective: The study was set up to determine to what extent the addition of a supplement of vitamin A alone or in combination with zinc would improve standard iron treatment and correction of iron deficiency anaemia. Design: 216 non-pregnant anaemic women of 15-45 years of age with haemoglobin levels less than or equal to 100 g/l were randomly assigned to three treatment groups. One group (A) received iron alone, a second group (B) received iron and vitamin A, and a third group (C) received iron, vitamin A and zinc. Every woman was given one iron capsule per day for 60 days as FeSO4 containing 60 mg of elemental iron. Ln addition, groups B and C received 200 000 IU of vitamin A, given as a supervised dose, on the first day of the treatment after collection of the blood sample. Group C received one zinc tablet per day for 60 days as zinc gluconate containing 15 mg of elemental zinc. Setting: The north-western part of Bangladesh in the urban slums of Dinajpur district between February and August 1995. Subjects: To select women with a haemoglobin level of less than or equal to 100 g/l, all the women of four randomly selected municipal slums of the district in the targeted age group (328) were invited to take part in the study. Blood samples were analysed for haemoglobin, serum iron, total iron binding capacity (TIBC), ferritin, retinol and zinc. Results: Out of the 328 women screened, 254 (77.5\%) had a haemoglobin level less than or equal to 100 g/l and 322 (98\%) less than or equal to 120 g/l. The three treatment schedules significantly increased haemoglobin levels and improved iron parameters, except for serum iron in the group who received iron alone. The group who received iron, vitamin A and zinc responded best with an increase in haemoglobin of 17.9 g/l as compared to the group receiving iron alone (13.4 g/l). Iron and vitamin A treatment gave an intermediate response of 15.9 g/l. However, these differences are only statistically significant only for the group who received iron, vitamin A and zinc and only for the increase in haemoglobin, P = 0.03. Conclusion: The results are suggestive that the addition of vitamin A and zinc to the treatment for anaemia can increase haemoglobin levels more than with iron alone. Sponsorship: The present study was financed by grant FWO 1.5.092.96 and Nutrition Tiers Monde.},
  author       = {Kolsteren, Patrick and Rahman, S and Hilderbrand, K and Diniz, A},
  issn         = {0954-3007},
  journal      = {EUROPEAN JOURNAL OF CLINICAL NUTRITION},
  keyword      = {NUTRITIONAL ANEMIA,NORTHEAST THAILAND,PREGNANT-WOMEN,A-DEFICIENCY,BREAST-MILK,WEST-JAVA,CHILDREN,METABOLISM,SERUM,TRANSFERRIN,Bangladesh,iron deficiency,vitamin A,women,zinc},
  language     = {eng},
  number       = {2},
  pages        = {102--106},
  title        = {Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh},
  url          = {http://dx.doi.org/10.1038/sj.ejcn.1600684},
  volume       = {53},
  year         = {1999},
}

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