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Signals from within: the DNA-damage-induced NF-κB response

(2006) CELL DEATH AND DIFFERENTIATION. 13(5). p.773-784
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Abstract
An appropriate response to genotoxic stress is essential for maintenance of genome stability and avoiding the passage to neoplasia. Nuclear factor kappa B (NF-kappa B) is activated as part of the DNA damage response and is thought to orchestrate a cell survival pathway, which, together with the activation of cell cycle checkpoints and DNA repair, allows the cell in cases of limited damage to restore a normal life cycle, unharmed. In this respect, NF-kappa B is one of the main factors accounting for chemotherapy resistance and as such impedes effective cancer treatment, representing an important drug target. Despite this high clinical relevance, signalling cascades leading to DNA damage-induced NF-kappa B activation are poorly understood and the use of highly divergent experimental set-ups in the past led to many controversies in the field. Therefore, in this review, we will try to summarize the current knowledge of distinct DNA damage-induced NF-kappa B signalling pathways.
Keywords
GENOTOXIC STRESS, IONIZING-RADIATION, GENE-EXPRESSION, TRANSCRIPTION FACTORS, ULTRAVIOLET-LIGHT, INDUCED APOPTOSIS, ECTODERMAL DYSPLASIA, CARCINOMA-CELLS, NF-kappa B, DNA damage, DEPENDENT PROTEIN-KINASE, signalling, NUCLEAR-FACTOR

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Citation

Please use this url to cite or link to this publication:

Chicago
Janssens, Sophie, and Jürg Tschopp. 2006. “Signals from Within: The DNA-damage-induced NF-κB Response.” Cell Death and Differentiation 13 (5): 773–784.
APA
Janssens, Sophie, & Tschopp, J. (2006). Signals from within: the DNA-damage-induced NF-κB response. CELL DEATH AND DIFFERENTIATION, 13(5), 773–784.
Vancouver
1.
Janssens S, Tschopp J. Signals from within: the DNA-damage-induced NF-κB response. CELL DEATH AND DIFFERENTIATION. 2006;13(5):773–84.
MLA
Janssens, Sophie, and Jürg Tschopp. “Signals from Within: The DNA-damage-induced NF-κB Response.” CELL DEATH AND DIFFERENTIATION 13.5 (2006): 773–784. Print.
@article{1202514,
  abstract     = {An appropriate response to genotoxic stress is essential for maintenance of genome stability and avoiding the passage to neoplasia. Nuclear factor kappa B (NF-kappa B) is activated as part of the DNA damage response and is thought to orchestrate a cell survival pathway, which, together with the activation of cell cycle checkpoints and DNA repair, allows the cell in cases of limited damage to restore a normal life cycle, unharmed. In this respect, NF-kappa B is one of the main factors accounting for chemotherapy resistance and as such impedes effective cancer treatment, representing an important drug target. Despite this high clinical relevance, signalling cascades leading to DNA damage-induced NF-kappa B activation are poorly understood and the use of highly divergent experimental set-ups in the past led to many controversies in the field. Therefore, in this review, we will try to summarize the current knowledge of distinct DNA damage-induced NF-kappa B signalling pathways.},
  author       = {Janssens, Sophie and Tschopp, Jürg},
  issn         = {1350-9047},
  journal      = {CELL DEATH AND DIFFERENTIATION},
  keywords     = {GENOTOXIC STRESS,IONIZING-RADIATION,GENE-EXPRESSION,TRANSCRIPTION FACTORS,ULTRAVIOLET-LIGHT,INDUCED APOPTOSIS,ECTODERMAL DYSPLASIA,CARCINOMA-CELLS,NF-kappa B,DNA damage,DEPENDENT PROTEIN-KINASE,signalling,NUCLEAR-FACTOR},
  language     = {eng},
  number       = {5},
  pages        = {773--784},
  title        = {Signals from within: the DNA-damage-induced NF-κB response},
  url          = {http://dx.doi.org/10.1038/sj.cdd.4401843},
  volume       = {13},
  year         = {2006},
}

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