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The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-Golgi network

Jody Haigh, Jennifer McVeigh and Peter Greer (1996) CELL GROWTH & DIFFERENTIATION. 7(7). p.931-944
abstract
The fps/fes proto-oncogene encodes a cytoplasmic protein tyrosine kinase that is thought to participate in signaling pathways involving members of the cytokine receptor superfamily, including those for erythropoietin, granulocyte-macrophage colony-stimulating factor, leukemia inhibitory factor, oncostatin M, ciliary neurotropic factor, and interleukins 3, 4, 6, and 11. Expression of fps/fes has been detected in hematopoietic cells, vascular endothelial cells, and cell types arising from all three germ layers during early development, Here, we describe fps/fes expression in developing and adult tissues from normal mice or from transgenic animals overexpressing wild-type or activated mutant fps/fes alleles, The highest levels of fps/fes expression were seen in angioblasts of early yolk sac blood islands, chondrocytes, vascular endothelial cells, neuronal cells, and several epithelial cell types, including those of the choroid plexus and the uterus, Fps/Fes protein was concentrated in the perinuclear region of cultured neuronal, myeloid, epithelial, and vascular endothelial cells, and a chimeric Fps/Fes-green fluorescence protein colocalized with gamma-adaptin, a marker for the trans-Golgi apparatus, These observations suggest the involvement of Fps/Fes in vesicle transport processes in cells with prominent secretory functions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FPS PROTEIN, SIGNALING PATHWAY, FES CDNA CLONES, GTPASE-ACTIVATING PROTEIN, BREFELDIN-A, SH2 DOMAIN, V-SRC, PHOSPHORYLATION, GENE, MICE
journal title
CELL GROWTH & DIFFERENTIATION
Cell Growth Differ.
volume
7
issue
7
pages
931 - 944
Web of Science type
Article
ISSN
1044-9523
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1202236
handle
http://hdl.handle.net/1854/LU-1202236
alternative location
http://cgd.aacrjournals.org/cgi/content/abstract/7/7/931
date created
2011-04-05 11:50:16
date last changed
2016-12-19 15:45:49
@article{1202236,
  abstract     = {The fps/fes proto-oncogene encodes a cytoplasmic protein tyrosine kinase that is thought to participate in signaling pathways involving members of the cytokine receptor superfamily, including those for erythropoietin, granulocyte-macrophage colony-stimulating factor, leukemia inhibitory factor, oncostatin M, ciliary neurotropic factor, and interleukins 3, 4, 6, and 11. Expression of fps/fes has been detected in hematopoietic cells, vascular endothelial cells, and cell types arising from all three germ layers during early development, Here, we describe fps/fes expression in developing and adult tissues from normal mice or from transgenic animals overexpressing wild-type or activated mutant fps/fes alleles, The highest levels of fps/fes expression were seen in angioblasts of early yolk sac blood islands, chondrocytes, vascular endothelial cells, neuronal cells, and several epithelial cell types, including those of the choroid plexus and the uterus, Fps/Fes protein was concentrated in the perinuclear region of cultured neuronal, myeloid, epithelial, and vascular endothelial cells, and a chimeric Fps/Fes-green fluorescence protein colocalized with gamma-adaptin, a marker for the trans-Golgi apparatus, These observations suggest the involvement of Fps/Fes in vesicle transport processes in cells with prominent secretory functions.},
  author       = {Haigh, Jody and McVeigh, Jennifer and Greer, Peter},
  issn         = {1044-9523},
  journal      = {CELL GROWTH \& DIFFERENTIATION},
  keyword      = {FPS PROTEIN,SIGNALING PATHWAY,FES CDNA CLONES,GTPASE-ACTIVATING PROTEIN,BREFELDIN-A,SH2 DOMAIN,V-SRC,PHOSPHORYLATION,GENE,MICE},
  language     = {eng},
  number       = {7},
  pages        = {931--944},
  title        = {The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-Golgi network},
  url          = {http://cgd.aacrjournals.org/cgi/content/abstract/7/7/931},
  volume       = {7},
  year         = {1996},
}

Chicago
Haigh, Jody, Jennifer McVeigh, and Peter Greer. 1996. “The Fps/fes Tyrosine Kinase Is Expressed in Myeloid, Vascular Endothelial, Epithelial, and Neuronal Cells and Is Localized in the trans-Golgi Network.” Cell Growth & Differentiation 7 (7): 931–944.
APA
Haigh, J., McVeigh, J., & Greer, P. (1996). The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-Golgi network. CELL GROWTH & DIFFERENTIATION, 7(7), 931–944.
Vancouver
1.
Haigh J, McVeigh J, Greer P. The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-Golgi network. CELL GROWTH & DIFFERENTIATION. 1996;7(7):931–44.
MLA
Haigh, Jody, Jennifer McVeigh, and Peter Greer. “The Fps/fes Tyrosine Kinase Is Expressed in Myeloid, Vascular Endothelial, Epithelial, and Neuronal Cells and Is Localized in the trans-Golgi Network.” CELL GROWTH & DIFFERENTIATION 7.7 (1996): 931–944. Print.