Ghent University Academic Bibliography

Advanced

Metabolic fate of polyphenols in the human superorganism

John van Duynhoven, Elaine E Vaughan, Doris M Jacobs, Robert A Kemperman, Ewoud JJ van Velzen, Gabriele Gross, Laure C Roger, Sam Possemiers UGent, Age K Smilde and Joel Dore, et al. (2011) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108(suppl. 1). p.4531-4538
abstract
Dietary polyphenols are components of many foods such as tea, fruit, and vegetables and are associated with several beneficial health effects although, sofar, largely based on epidemiological studies. The intact forms of complex dietary polyphenols have limited bioavailability, with low circulating levels in plasma. A major part of the polyphenols persists in the colon, where the resident microbiota produce metabolites that can undergo further metabolism upon entering systemic circulation. Unraveling the complex metabolic fate of polyphenols in this human superorganism requires joint deployment of in vitro and humanized mouse models and human intervention trials. Within these systems, the variation in diversity and functionality of the colonic microbiota can increasingly be captured by rapidly developing microbiomics and metabolomics technologies. Furthermore, metabolomics is coming to grips with the large biological variation superimposed on relatively subtle effects of dietary interventions. In particular when metabolomics is deployed in conjunction with a longitudinal study design, quantitative nutrikinetic signatures can be obtained. These signatures can be used to define nutritional phenotypes with different kinetic characteristics for the bioconversion capacity for polyphenols. Bottom-up as well as top-down approaches need to be pursued to link gut microbial diversity to functionality in nutritional phenotypes and, ultimately, to bioactivity of polyphenols. This approach will pave the way for personalization of nutrition based on gut microbial functionality of individuals or populations.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
gut microbiota, polyphenol bioconversion, metabolomics, metagenomics, microbiomics, MICROBIAL FERMENTATION PRODUCTS, 8-PRENYLNARINGENIN IN-VITRO, CONTINUOUS-CULTURE SYSTEM, RED WINE POLYPHENOLS, HUMULUS-LUPULUS L., INTESTINAL MICROBIOTA, DIETARY POLYPHENOLS, NUTRITION RESEARCH, GUT MICROFLORA, GASTROINTESTINAL-TRACT
journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proc. Natl. Acad. Sci. U. S. A.
volume
108
issue
suppl. 1
pages
4531 - 4538
Web of Science type
Article
Web of Science id
000288451300004
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
9.681 (2011)
JCR rank
3/54 (2011)
JCR quartile
1 (2011)
ISSN
0027-8424
DOI
10.1073/pnas.1000098107
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1201610
handle
http://hdl.handle.net/1854/LU-1201610
date created
2011-04-01 16:34:25
date last changed
2011-04-28 16:09:00
@article{1201610,
  abstract     = {Dietary polyphenols are components of many foods such as tea, fruit, and vegetables and are associated with several beneficial health effects although, sofar, largely based on epidemiological studies. The intact forms of complex dietary polyphenols have limited bioavailability, with low circulating levels in plasma. A major part of the polyphenols persists in the colon, where the resident microbiota produce metabolites that can undergo further metabolism upon entering systemic circulation. Unraveling the complex metabolic fate of polyphenols in this human superorganism requires joint deployment of in vitro and humanized mouse models and human intervention trials. Within these systems, the variation in diversity and functionality of the colonic microbiota can increasingly be captured by rapidly developing microbiomics and metabolomics technologies. Furthermore, metabolomics is coming to grips with the large biological variation superimposed on relatively subtle effects of dietary interventions. In particular when metabolomics is deployed in conjunction with a longitudinal study design, quantitative nutrikinetic signatures can be obtained. These signatures can be used to define nutritional phenotypes with different kinetic characteristics for the bioconversion capacity for polyphenols. Bottom-up as well as top-down approaches need to be pursued to link gut microbial diversity to functionality in nutritional phenotypes and, ultimately, to bioactivity of polyphenols. This approach will pave the way for personalization of nutrition based on gut microbial functionality of individuals or populations.},
  author       = {van Duynhoven, John and Vaughan, Elaine E and Jacobs, Doris M and Kemperman, Robert A and van Velzen, Ewoud JJ and Gross, Gabriele and Roger, Laure C and Possemiers, Sam and Smilde, Age K and Dore, Joel and Westerhuis, Johan A and Van de Wiele, Tom},
  issn         = {0027-8424},
  journal      = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
  keyword      = {gut microbiota,polyphenol bioconversion,metabolomics,metagenomics,microbiomics,MICROBIAL FERMENTATION PRODUCTS,8-PRENYLNARINGENIN IN-VITRO,CONTINUOUS-CULTURE SYSTEM,RED WINE POLYPHENOLS,HUMULUS-LUPULUS L.,INTESTINAL MICROBIOTA,DIETARY POLYPHENOLS,NUTRITION RESEARCH,GUT MICROFLORA,GASTROINTESTINAL-TRACT},
  language     = {eng},
  number       = {suppl. 1},
  pages        = {4531--4538},
  title        = {Metabolic fate of polyphenols in the human superorganism},
  url          = {http://dx.doi.org/10.1073/pnas.1000098107},
  volume       = {108},
  year         = {2011},
}

Chicago
van Duynhoven, John, Elaine E Vaughan, Doris M Jacobs, Robert A Kemperman, Ewoud JJ van Velzen, Gabriele Gross, Laure C Roger, et al. 2011. “Metabolic Fate of Polyphenols in the Human Superorganism.” Proceedings of the National Academy of Sciences of the United States of America 108 (suppl. 1): 4531–4538.
APA
van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., Kemperman, R. A., van Velzen, E. J., Gross, G., Roger, L. C., et al. (2011). Metabolic fate of polyphenols in the human superorganism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(suppl. 1), 4531–4538.
Vancouver
1.
van Duynhoven J, Vaughan EE, Jacobs DM, Kemperman RA, van Velzen EJ, Gross G, et al. Metabolic fate of polyphenols in the human superorganism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(suppl. 1):4531–8.
MLA
van Duynhoven, John, Elaine E Vaughan, Doris M Jacobs, et al. “Metabolic Fate of Polyphenols in the Human Superorganism.” PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.suppl. 1 (2011): 4531–4538. Print.