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Clinical presentation, evolution, and prognosis of precursor B-cell lymphoblastic lymphoma in trials LMT96, EORTC 58881, and EORTC 58951

(2011) BRITISH JOURNAL OF HAEMATOLOGY. 152(4). p.441-451
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Abstract
In children, lymphoblastic lymphomas represent 30% of Non-Hodgkin lymphomas (NHL), and approximately 15% are precursor B-cell lymphomas (PBLL). Our study evaluated their main clinical characteristics, evolution, and prognosis in three trials. From 1989 to 2008, 53 children with PBLL (median age 7·75 years) were included in three protocols: Malignant Lymphoma Therapy (LMT) 96, European Organization for Research and Treatment of Cancer (EORTC) 58881, and EORTC 58951 using Berlin-Frankfürt-Münster-derived acute lymphoblastic leukaemia (ALL) therapy. There were 10 stage I disease, 9 stage II, 9 stage III and 25 stage IV. Clinical presentation was heterogeneous with a majority of bone lesions and cutaneous or subcutaneous manifestations. At diagnosis 23 patients had bone marrow involvement, and only three had central nervous system involvement. The median follow-up was 74 months. At last follow-up, 45 patients were in continuous complete remission, whereas eight had progressed or had relapsed (7 Stages IV and 1 Stage III) and died. Two patients had a secondary neoplasia, and are still alive. Disease stage was a major prognostic factor, with better overall survival (OS) and event-free survival (EFS) (P < 0·05) rates observed in patients with Stage I to III as compared to those with Stage IV. Treatment with protocols derived from ALL therapy are efficient with an 82% EFS and an 85% OS at 5 years.
Keywords
lymphoblastic lymphoma, precursor B-cell, children, NON-HODGKINS-LYMPHOMA, OF-THE-LITERATURE, CHILDRENS CANCER GROUP, CHILDHOOD, LEUKEMIA, STAGE, ADOLESCENCE, CLASSIFICATION, RADIOTHERAPY, FEATURES

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Chicago
Ducassou, Stéphane, Céline Ferlay, Christophe Bergeron, Sandrine Girard, Genevieve Laureys, Hélène Pacquement, Dominique Plantaz, et al. 2011. “Clinical Presentation, Evolution, and Prognosis of Precursor B-cell Lymphoblastic Lymphoma in Trials LMT96, EORTC 58881, and EORTC 58951.” British Journal of Haematology 152 (4): 441–451.
APA
Ducassou, S., Ferlay, C., Bergeron, C., Girard, S., Laureys, G., Pacquement, H., Plantaz, D., et al. (2011). Clinical presentation, evolution, and prognosis of precursor B-cell lymphoblastic lymphoma in trials LMT96, EORTC 58881, and EORTC 58951. BRITISH JOURNAL OF HAEMATOLOGY, 152(4), 441–451.
Vancouver
1.
Ducassou S, Ferlay C, Bergeron C, Girard S, Laureys G, Pacquement H, et al. Clinical presentation, evolution, and prognosis of precursor B-cell lymphoblastic lymphoma in trials LMT96, EORTC 58881, and EORTC 58951. BRITISH JOURNAL OF HAEMATOLOGY. 2011;152(4):441–51.
MLA
Ducassou, Stéphane, Céline Ferlay, Christophe Bergeron, et al. “Clinical Presentation, Evolution, and Prognosis of Precursor B-cell Lymphoblastic Lymphoma in Trials LMT96, EORTC 58881, and EORTC 58951.” BRITISH JOURNAL OF HAEMATOLOGY 152.4 (2011): 441–451. Print.
@article{1199570,
  abstract     = {In children, lymphoblastic lymphomas represent 30% of Non-Hodgkin lymphomas (NHL), and approximately 15% are precursor B-cell lymphomas (PBLL). Our study evaluated their main clinical characteristics, evolution, and prognosis in three trials. From 1989 to 2008, 53 children with PBLL (median age 7·75 years) were included in three protocols: Malignant Lymphoma Therapy (LMT) 96, European Organization for Research and Treatment of Cancer (EORTC) 58881, and EORTC 58951 using Berlin-Frankfürt-Münster-derived acute lymphoblastic leukaemia (ALL) therapy. There were 10 stage I disease, 9 stage II, 9 stage III and 25 stage IV. Clinical presentation was heterogeneous with a majority of bone lesions and cutaneous or subcutaneous manifestations. At diagnosis 23 patients had bone marrow involvement, and only three had central nervous system involvement. The median follow-up was 74 months. At last follow-up, 45 patients were in continuous complete remission, whereas eight had progressed or had relapsed (7 Stages IV and 1 Stage III) and died. Two patients had a secondary neoplasia, and are still alive. Disease stage was a major prognostic factor, with better overall survival (OS) and event-free survival (EFS) (P < 0·05) rates observed in patients with Stage I to III as compared to those with Stage IV. Treatment with protocols derived from ALL therapy are efficient with an 82% EFS and an 85% OS at 5 years.},
  author       = {Ducassou, Stéphane and Ferlay, Céline and Bergeron, Christophe and Girard, Sandrine and Laureys, Genevieve and Pacquement, Hélène and Plantaz, Dominique and Lutz, Patrick and Vannier, Jean-Pierre and Uyttebroeck, Anna and Bertrand, Yves},
  issn         = {0007-1048},
  journal      = {BRITISH JOURNAL OF HAEMATOLOGY},
  keywords     = {lymphoblastic lymphoma,precursor B-cell,children,NON-HODGKINS-LYMPHOMA,OF-THE-LITERATURE,CHILDRENS CANCER GROUP,CHILDHOOD,LEUKEMIA,STAGE,ADOLESCENCE,CLASSIFICATION,RADIOTHERAPY,FEATURES},
  language     = {eng},
  number       = {4},
  pages        = {441--451},
  title        = {Clinical presentation, evolution, and prognosis of precursor B-cell lymphoblastic lymphoma in trials LMT96, EORTC 58881, and EORTC 58951},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2010.08541.x},
  volume       = {152},
  year         = {2011},
}

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