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Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) CELL DEATH AND DIFFERENTIATION. 18(4). p.581-588
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Neutrophil extracellular traps (NETs) are chromatin structures loaded with antimicrobial molecules. They can trap and kill various bacterial, fungal and protozoal pathogens, and their release is one of the first lines of defense against pathogens. In vivo, NETs are released during a form of pathogen-induced cell death, which was recently named NETosis. Ex vivo, both dead and viable neutrophils can be stimulated to release NETs composed of either nuclear or mitochondrial chromatin, respectively. In certain pathological conditions, NETs are associated with severe tissue damage or certain auto-immune diseases. This review describes the recent progress made in the identification of the mechanisms involved in NETosis and discusses its interplay with autophagy and apoptosis.
Keywords
superoxide, autophagy, NETosis, NADPH oxidase, cell death, NEUTROPHIL EXTRACELLULAR TRAPS, CHRONIC GRANULOMATOUS-DISEASE, NF-KAPPA-B, AUTOPHAGY GENE ATG5, NADPH OXIDASE, PEPTIDYLARGININE DEIMINASE-4, MITOCHONDRIAL-DNA, STREPTOCOCCUS-PNEUMONIAE, RHEUMATOID-ARTHRITIS, HISTONE DEIMINATION

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Citation

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Chicago
Remijsen, Quinten, TW Kuijpers, Ellen Wirawan, Saskia Lippens, Peter Vandenabeele, and Tom Vanden Berghe. 2011. “Dying for a Cause: NETosis, Mechanisms Behind an Antimicrobial Cell Death Modality.” Cell Death and Differentiation 18 (4): 581–588.
APA
Remijsen, Q., Kuijpers, T., Wirawan, E., Lippens, S., Vandenabeele, P., & Vanden Berghe, T. (2011). Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. CELL DEATH AND DIFFERENTIATION, 18(4), 581–588.
Vancouver
1.
Remijsen Q, Kuijpers T, Wirawan E, Lippens S, Vandenabeele P, Vanden Berghe T. Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. CELL DEATH AND DIFFERENTIATION. 2011;18(4):581–8.
MLA
Remijsen, Quinten, TW Kuijpers, Ellen Wirawan, et al. “Dying for a Cause: NETosis, Mechanisms Behind an Antimicrobial Cell Death Modality.” CELL DEATH AND DIFFERENTIATION 18.4 (2011): 581–588. Print.
@article{1197964,
  abstract     = {Neutrophil extracellular traps (NETs) are chromatin structures loaded with antimicrobial molecules. They can trap and kill various bacterial, fungal and protozoal pathogens, and their release is one of the first lines of defense against pathogens. In vivo, NETs are released during a form of pathogen-induced cell death, which was recently named NETosis. Ex vivo, both dead and viable neutrophils can be stimulated to release NETs composed of either nuclear or mitochondrial chromatin, respectively. In certain pathological conditions, NETs are associated with severe tissue damage or certain auto-immune diseases. This review describes the recent progress made in the identification of the mechanisms involved in NETosis and discusses its interplay with autophagy and apoptosis.},
  author       = {Remijsen, Quinten and Kuijpers, TW and Wirawan, Ellen and Lippens, Saskia and Vandenabeele, Peter and Vanden Berghe, Tom},
  issn         = {1350-9047},
  journal      = {CELL DEATH AND DIFFERENTIATION},
  keyword      = {superoxide,autophagy,NETosis,NADPH oxidase,cell death,NEUTROPHIL EXTRACELLULAR TRAPS,CHRONIC GRANULOMATOUS-DISEASE,NF-KAPPA-B,AUTOPHAGY GENE ATG5,NADPH OXIDASE,PEPTIDYLARGININE DEIMINASE-4,MITOCHONDRIAL-DNA,STREPTOCOCCUS-PNEUMONIAE,RHEUMATOID-ARTHRITIS,HISTONE DEIMINATION},
  language     = {eng},
  number       = {4},
  pages        = {581--588},
  title        = {Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality},
  url          = {http://dx.doi.org/10.1038/cdd.2011.1},
  volume       = {18},
  year         = {2011},
}

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