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A comparison of MS2-based label-free quantitative proteomic techniques with regards to accuracy and precision

Niklaas Colaert (UGent) , Joël Vandekerckhove (UGent) , Kris Gevaert (UGent) and Lennart Martens (UGent)
(2011) PROTEOMICS. 11(6). p.1110-1113
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Bioinformatics: from nucleotids to networks (N2N)
Abstract
The advent of algorithms for fragmentation spectrum-based label-free quantitative proteomics has enabled straightforward quantification of shotgun proteomic experiments. Despite the popularity of these approaches, few studies have been performed to assess their performance. We have therefore profiled the precision and the accuracy of three distinct relative label-free methods on both the protein and the proteome level. We derived our test data from two well-characterized publicly available quantitative data sets.
Keywords
PROTEIN, QUANTIFICATION, Quantitative proteomics, Quality control, Precision, Label free, Bioinformatics, Accuracy, QUANTIFICATION, PROTEIN

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Citation

Please use this url to cite or link to this publication:

Chicago
Colaert, Niklaas, Joël Vandekerckhove, Kris Gevaert, and Lennart Martens. 2011. “A Comparison of MS2-based Label-free Quantitative Proteomic Techniques with Regards to Accuracy and Precision.” Proteomics 11 (6): 1110–1113.
APA
Colaert, N., Vandekerckhove, J., Gevaert, K., & Martens, L. (2011). A comparison of MS2-based label-free quantitative proteomic techniques with regards to accuracy and precision. PROTEOMICS, 11(6), 1110–1113.
Vancouver
1.
Colaert N, Vandekerckhove J, Gevaert K, Martens L. A comparison of MS2-based label-free quantitative proteomic techniques with regards to accuracy and precision. PROTEOMICS. 2011;11(6):1110–3.
MLA
Colaert, Niklaas, Joël Vandekerckhove, Kris Gevaert, et al. “A Comparison of MS2-based Label-free Quantitative Proteomic Techniques with Regards to Accuracy and Precision.” PROTEOMICS 11.6 (2011): 1110–1113. Print.
@article{1197739,
  abstract     = {The advent of algorithms for fragmentation spectrum-based label-free quantitative proteomics has enabled straightforward quantification of shotgun proteomic experiments. Despite the popularity of these approaches, few studies have been performed to assess their performance. We have therefore profiled the precision and the accuracy of three distinct relative label-free methods on both the protein and the proteome level. We derived our test data from two well-characterized publicly available quantitative data sets.},
  author       = {Colaert, Niklaas and Vandekerckhove, Jo{\"e}l and Gevaert, Kris and Martens, Lennart},
  issn         = {1615-9853},
  journal      = {PROTEOMICS},
  keyword      = {PROTEIN,QUANTIFICATION,Quantitative proteomics,Quality control,Precision,Label free,Bioinformatics,Accuracy,QUANTIFICATION,PROTEIN},
  language     = {eng},
  number       = {6},
  pages        = {1110--1113},
  title        = {A comparison of MS2-based label-free quantitative proteomic techniques with regards to accuracy and precision},
  url          = {http://dx.doi.org/10.1002/pmic.201000521},
  volume       = {11},
  year         = {2011},
}

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