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Numerical model for CFD-simulation of the flow field in the anastomosis region of coronary bypasses

Marloes De Witte UGent, Abigaïl Swillens UGent, Lasse Lovstakken, Havard Nordgaard, Denis Van Loo UGent, Bram Trachet UGent, Jan Vierendeels UGent and Patrick Segers UGent (2011) Conference proceedings CMBE11. p.387-390
abstract
Coronary artery bypass surgery is a treatment for ischemic heart disease and can increase life quality and expectancy. The results after the treatment depend largely on the patency of the bypass grafts, which are used to bypass the narrowed arteries on the heart. Long-term patency is mainly determined by the progression of atherosclerosis and intimal hyperplasia (IH) within the bypass grafts, which are believed to be related to unfavourable wall shear stress (e.g. low and oscillatory WSS) exerted on the endothelial cells. To investigate the potential role of hemodynamic forces on the endothelial cells and the impact of the severity of the bypassed arterial stenosis on the flow fields, we developed a computational model of a LIMA-to-LAD anastomosis region obtained from a porcine in-vivo cast. In addition, the same porcine experiment provided the necessary up- and downstream boundary conditions for the simulations. The model has been applied to simulate the flow field in 5 cases, corresponding with 100, 97, 90, 75 and 0% LAD stenosis, in order to quantify the effect of the stenosis on resulting flow fields and on WSS distributions. Low stenosis degrees are associated with competitive LAD and LIMA flow and low WSS in the LIMA, which might contribute to WSS-related remodeling and suboptimal performance of the LIMA bypass.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
wall shear stress, CFD, LIMA-to-LAD anastomosis, numerical modeling
in
Conference proceedings CMBE11
editor
Perumal Nithiarasu, Rainald Löhner, Raoul Van Loon, Igor Sazonov and Xianghua Xie
pages
387 - 390
publisher
All American Printing
place of publication
Alexandria, VA, USA
conference name
2nd International Conference on Computational & Mathematical Biomedical Engineering (CMBE - 2011)
conference location
Washington, DC, USA
conference start
2011-03-30
conference end
2011-04-01
ISBN
9780956291417
language
English
UGent publication?
yes
classification
C1
copyright statement
I have retained and own the full copyright for this publication
id
1196747
handle
http://hdl.handle.net/1854/LU-1196747
alternative location
http://www.cs.swan.ac.uk/~csjason/cmbe2011.pdf
date created
2011-03-25 10:21:25
date last changed
2011-06-24 12:49:44
@inproceedings{1196747,
  abstract     = {Coronary artery bypass surgery is a treatment for ischemic heart disease and can increase life quality and expectancy. The results after the treatment depend largely on the patency of the bypass grafts, which are used to bypass the narrowed arteries on the heart. Long-term patency is mainly determined by the progression of atherosclerosis and intimal hyperplasia (IH) within the bypass grafts, which are believed to be related to unfavourable wall shear stress (e.g. low and oscillatory WSS) exerted on the endothelial cells. To investigate the potential role of hemodynamic forces on the endothelial cells and the impact of the severity of the bypassed arterial stenosis on the flow fields, we developed a computational model of a LIMA-to-LAD anastomosis region obtained from a porcine in-vivo cast. In addition, the same porcine experiment provided the necessary up- and downstream boundary conditions for the simulations. The model has been applied to simulate the flow field in 5 cases, corresponding with 100, 97, 90, 75 and 0\% LAD stenosis, in order to quantify the effect of the stenosis on resulting flow fields and on WSS distributions. Low stenosis degrees are associated with competitive LAD and LIMA flow and low WSS in the LIMA, which might contribute to WSS-related remodeling and suboptimal performance of the LIMA bypass.},
  author       = {De Witte, Marloes and Swillens, Abiga{\"i}l and Lovstakken, Lasse  and Nordgaard, Havard and Van Loo, Denis and Trachet, Bram and Vierendeels, Jan and Segers, Patrick},
  booktitle    = {Conference proceedings CMBE11},
  editor       = {Nithiarasu, Perumal and L{\"o}hner, Rainald and Van Loon, Raoul and Sazonov, Igor and Xie, Xianghua},
  isbn         = {9780956291417},
  keyword      = {wall shear stress,CFD,LIMA-to-LAD anastomosis,numerical modeling},
  language     = {eng},
  location     = {Washington, DC, USA},
  pages        = {387--390},
  publisher    = {All American Printing},
  title        = {Numerical model for CFD-simulation of the flow field in the anastomosis region of coronary bypasses},
  url          = {http://www.cs.swan.ac.uk/{\texttildelow}csjason/cmbe2011.pdf},
  year         = {2011},
}

Chicago
De Witte, Marloes, Abigaïl Swillens, Lasse Lovstakken, Havard Nordgaard, Denis Van Loo, Bram Trachet, Jan Vierendeels, and Patrick Segers. 2011. “Numerical Model for CFD-simulation of the Flow Field in the Anastomosis Region of Coronary Bypasses.” In Conference Proceedings CMBE11, ed. Perumal Nithiarasu, Rainald Löhner, Raoul Van Loon, Igor Sazonov, and Xianghua Xie, 387–390. Alexandria, VA, USA: All American Printing.
APA
De Witte, M., Swillens, A., Lovstakken, L., Nordgaard, H., Van Loo, D., Trachet, B., Vierendeels, J., et al. (2011). Numerical model for CFD-simulation of the flow field in the anastomosis region of coronary bypasses. In P. Nithiarasu, R. Löhner, R. Van Loon, I. Sazonov, & X. Xie (Eds.), Conference proceedings CMBE11 (pp. 387–390). Presented at the 2nd International Conference on Computational & Mathematical Biomedical Engineering (CMBE - 2011), Alexandria, VA, USA: All American Printing.
Vancouver
1.
De Witte M, Swillens A, Lovstakken L, Nordgaard H, Van Loo D, Trachet B, et al. Numerical model for CFD-simulation of the flow field in the anastomosis region of coronary bypasses. In: Nithiarasu P, Löhner R, Van Loon R, Sazonov I, Xie X, editors. Conference proceedings CMBE11. Alexandria, VA, USA: All American Printing; 2011. p. 387–90.
MLA
De Witte, Marloes, Abigaïl Swillens, Lasse Lovstakken, et al. “Numerical Model for CFD-simulation of the Flow Field in the Anastomosis Region of Coronary Bypasses.” Conference Proceedings CMBE11. Ed. Perumal Nithiarasu et al. Alexandria, VA, USA: All American Printing, 2011. 387–390. Print.