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Compound specific δ13 determination of urinary steroid metabolites by GC-C-IRMS for human doping control: Preliminary GC-C-IRMS results from a Belgian control population and testosterone administration studies

Pieter Van Renterghem UGent, Lance Brooker UGent, Wim Van Gansbeke UGent and Peter Van Eenoo UGent (2011) Benelux Association of Stable Isotope Scientist (BASIS - 2011), Abstracts. p.29-29
abstract
Recently, the World Anti-doping Agency accredited Doping Control Laboratory of Belgium (DoCoLab) was obliged to implement a method for the compound-specific isotopic analysis (CSIA) of urinary steroid metabolites. GC-C-IRMS determination of 13C values is used for the confirmation of the administration of endogenous anabolic androgenic steroids (AAS) such as testosterone by athletes. This presentation will outline the development and validation of the method which utilizes a Thermo MAT253 GC-C-IRMS equipped with GCIsolink and ConFloIV for analysis. Preliminary results from a Belgian control population of 50 blank urines samples will be discussed. Furthermore, the effectiveness of recent advances in steroid profiling for the identification of suspicious samples as proposed by our laboratory, will be tested by the application of GC-C-IRMS to samples originating from testosterone administration studies.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
Control population, Testosterone administration study, GC-C-IRMS, Doping analysis
in
Benelux Association of Stable Isotope Scientist (BASIS - 2011), Abstracts
pages
29 - 29
publisher
Cito Arnhem
place of publication
Arnhem, Nederland
conference name
Benelux Association of Stable Isotope Scientist (BASIS - 2011)
conference location
Bruges, Belgium
conference start
2011-03-17
conference end
2011-03-18
language
English
UGent publication?
yes
classification
C3
id
1195232
handle
http://hdl.handle.net/1854/LU-1195232
date created
2011-03-23 11:23:56
date last changed
2011-05-16 14:32:48
@inproceedings{1195232,
  abstract     = {Recently, the World Anti-doping Agency accredited Doping Control Laboratory of Belgium (DoCoLab) was obliged to implement a method for the compound-specific isotopic analysis (CSIA) of urinary steroid metabolites. GC-C-IRMS determination of \unmatched{f064}13C values is used for the confirmation of the administration of endogenous anabolic androgenic steroids (AAS) such as testosterone by athletes. This presentation will outline the development and validation of the method which utilizes a Thermo MAT253 GC-C-IRMS equipped with GCIsolink and ConFloIV for analysis. Preliminary results from a Belgian control population of 50 blank urines samples will be discussed. Furthermore, the effectiveness of recent advances in steroid profiling for the identification of suspicious samples as proposed by our laboratory, will be tested by the application of GC-C-IRMS to samples originating from testosterone administration studies.},
  author       = {Van Renterghem, Pieter and Brooker, Lance and Van Gansbeke, Wim and Van Eenoo, Peter},
  booktitle    = {Benelux Association of Stable Isotope Scientist (BASIS - 2011), Abstracts},
  keyword      = {Control population,Testosterone administration study,GC-C-IRMS,Doping analysis},
  language     = {eng},
  location     = {Bruges, Belgium},
  pages        = {29--29},
  publisher    = {Cito Arnhem},
  title        = {Compound specific \ensuremath{\delta}13 determination of urinary steroid metabolites by GC-C-IRMS for human doping control: \unmatched{000b}\unmatched{000b}Preliminary GC-C-IRMS results from a \unmatched{000b}Belgian control population and \unmatched{000b}testosterone administration studies},
  year         = {2011},
}

Chicago
Van Renterghem, Pieter, Lance Brooker, Wim Van Gansbeke, and Peter Van Eenoo. 2011. “Compound Specific Δ13 Determination of Urinary Steroid Metabolites by GC-C-IRMS for Human Doping Control: Preliminary GC-C-IRMS Results from a Belgian Control Population and Testosterone Administration Studies.” In Benelux Association of Stable Isotope Scientist (BASIS - 2011), Abstracts, 29–29. Arnhem, Nederland: Cito Arnhem.
APA
Van Renterghem, P., Brooker, L., Van Gansbeke, W., & Van Eenoo, P. (2011). Compound specific δ13 determination of urinary steroid metabolites by GC-C-IRMS for human doping control: Preliminary GC-C-IRMS results from a Belgian control population and testosterone administration studies. Benelux Association of Stable Isotope Scientist (BASIS - 2011), Abstracts (pp. 29–29). Presented at the Benelux Association of Stable Isotope Scientist (BASIS - 2011), Arnhem, Nederland: Cito Arnhem.
Vancouver
1.
Van Renterghem P, Brooker L, Van Gansbeke W, Van Eenoo P. Compound specific δ13 determination of urinary steroid metabolites by GC-C-IRMS for human doping control: Preliminary GC-C-IRMS results from a Belgian control population and testosterone administration studies. Benelux Association of Stable Isotope Scientist (BASIS - 2011), Abstracts. Arnhem, Nederland: Cito Arnhem; 2011. p. 29–29.
MLA
Van Renterghem, Pieter, Lance Brooker, Wim Van Gansbeke, et al. “Compound Specific Δ13 Determination of Urinary Steroid Metabolites by GC-C-IRMS for Human Doping Control: Preliminary GC-C-IRMS Results from a Belgian Control Population and Testosterone Administration Studies.” Benelux Association of Stable Isotope Scientist (BASIS - 2011), Abstracts. Arnhem, Nederland: Cito Arnhem, 2011. 29–29. Print.