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Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation

(2010) FUTURE ONCOLOGY. 6(9). p.1485-1496
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Abstract
The combination of radiotherapy with chemotherapeutic agents that sensitize tumor cells to ionizing radiation has long been regarded as a promising strategy to enhance cancer therapy. Many chemotherapeutic agents interact with radiation and enhance the cytotoxic or anti-tumor effect of radiation through a number of mechanisms. These include an increase in initial radiation damage, inhibition of cellular repair, cell cycle redistribution, enhancement of apoptosis, counteracting hypoxia and overcoming accelerated repopulation. This article focuses on the role of cell cycle perturbations in the radiosensitivity of cancer cells.
Keywords
INDUCED RADIOSENSITIZATION, IONIZING-RADIATION, DNA-DAMAGE, TUMOR-CELLS, S-PHASE, IN-VITRO, LUNG-CANCER CELLS, radiotherapy, radiosensitization, chemotherapy, cell cycle, chemoradiation, DOCETAXEL TAXOTERE, ANTITUMOR-ACTIVITY, ANTICANCER DRUGS

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Chicago
Pauwels, Bea, An Wouters, Marc Peeters, Jan B Vermorken, and Filip Lardon. 2010. “Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation.” Future Oncology 6 (9): 1485–1496.
APA
Pauwels, Bea, Wouters, A., Peeters, M., Vermorken, J. B., & Lardon, F. (2010). Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation. FUTURE ONCOLOGY, 6(9), 1485–1496.
Vancouver
1.
Pauwels B, Wouters A, Peeters M, Vermorken JB, Lardon F. Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation. FUTURE ONCOLOGY. 2010;6(9):1485–96.
MLA
Pauwels, Bea, An Wouters, Marc Peeters, et al. “Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation.” FUTURE ONCOLOGY 6.9 (2010): 1485–1496. Print.
@article{1193742,
  abstract     = {The combination of radiotherapy with chemotherapeutic agents that sensitize tumor cells to ionizing radiation has long been regarded as a promising strategy to enhance cancer therapy. Many chemotherapeutic agents interact with radiation and enhance the cytotoxic or anti-tumor effect of radiation through a number of mechanisms. These include an increase in initial radiation damage, inhibition of cellular repair, cell cycle redistribution, enhancement of apoptosis, counteracting hypoxia and overcoming accelerated repopulation. This article focuses on the role of cell cycle perturbations in the radiosensitivity of cancer cells.},
  author       = {Pauwels, Bea and Wouters, An and Peeters, Marc and Vermorken, Jan B and Lardon, Filip},
  issn         = {1479-6694},
  journal      = {FUTURE ONCOLOGY},
  language     = {eng},
  number       = {9},
  pages        = {1485--1496},
  title        = {Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation},
  url          = {http://dx.doi.org/10.2217/FON.10.104},
  volume       = {6},
  year         = {2010},
}

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