Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation
- Author
- Bea Pauwels, An Wouters, Marc Peeters (UGent) , Jan B Vermorken and Filip Lardon
- Organization
- Abstract
- The combination of radiotherapy with chemotherapeutic agents that sensitize tumor cells to ionizing radiation has long been regarded as a promising strategy to enhance cancer therapy. Many chemotherapeutic agents interact with radiation and enhance the cytotoxic or anti-tumor effect of radiation through a number of mechanisms. These include an increase in initial radiation damage, inhibition of cellular repair, cell cycle redistribution, enhancement of apoptosis, counteracting hypoxia and overcoming accelerated repopulation. This article focuses on the role of cell cycle perturbations in the radiosensitivity of cancer cells.
- Keywords
- INDUCED RADIOSENSITIZATION, IONIZING-RADIATION, DNA-DAMAGE, TUMOR-CELLS, S-PHASE, IN-VITRO, LUNG-CANCER CELLS, radiotherapy, radiosensitization, chemotherapy, cell cycle, chemoradiation, DOCETAXEL TAXOTERE, ANTITUMOR-ACTIVITY, ANTICANCER DRUGS
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1193742
- MLA
- Pauwels, Bea, et al. “Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation.” FUTURE ONCOLOGY, vol. 6, no. 9, 2010, pp. 1485–96, doi:10.2217/FON.10.104.
- APA
- Pauwels, B., Wouters, A., Peeters, M., Vermorken, J. B., & Lardon, F. (2010). Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation. FUTURE ONCOLOGY, 6(9), 1485–1496. https://doi.org/10.2217/FON.10.104
- Chicago author-date
- Pauwels, Bea, An Wouters, Marc Peeters, Jan B Vermorken, and Filip Lardon. 2010. “Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation.” FUTURE ONCOLOGY 6 (9): 1485–96. https://doi.org/10.2217/FON.10.104.
- Chicago author-date (all authors)
- Pauwels, Bea, An Wouters, Marc Peeters, Jan B Vermorken, and Filip Lardon. 2010. “Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation.” FUTURE ONCOLOGY 6 (9): 1485–1496. doi:10.2217/FON.10.104.
- Vancouver
- 1.Pauwels B, Wouters A, Peeters M, Vermorken JB, Lardon F. Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation. FUTURE ONCOLOGY. 2010;6(9):1485–96.
- IEEE
- [1]B. Pauwels, A. Wouters, M. Peeters, J. B. Vermorken, and F. Lardon, “Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation,” FUTURE ONCOLOGY, vol. 6, no. 9, pp. 1485–1496, 2010.
@article{1193742,
abstract = {{The combination of radiotherapy with chemotherapeutic agents that sensitize tumor cells to ionizing radiation has long been regarded as a promising strategy to enhance cancer therapy. Many chemotherapeutic agents interact with radiation and enhance the cytotoxic or anti-tumor effect of radiation through a number of mechanisms. These include an increase in initial radiation damage, inhibition of cellular repair, cell cycle redistribution, enhancement of apoptosis, counteracting hypoxia and overcoming accelerated repopulation. This article focuses on the role of cell cycle perturbations in the radiosensitivity of cancer cells.}},
author = {{Pauwels, Bea and Wouters, An and Peeters, Marc and Vermorken, Jan B and Lardon, Filip}},
issn = {{1479-6694}},
journal = {{FUTURE ONCOLOGY}},
keywords = {{INDUCED RADIOSENSITIZATION,IONIZING-RADIATION,DNA-DAMAGE,TUMOR-CELLS,S-PHASE,IN-VITRO,LUNG-CANCER CELLS,radiotherapy,radiosensitization,chemotherapy,cell cycle,chemoradiation,DOCETAXEL TAXOTERE,ANTITUMOR-ACTIVITY,ANTICANCER DRUGS}},
language = {{eng}},
number = {{9}},
pages = {{1485--1496}},
title = {{Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation}},
url = {{http://doi.org/10.2217/FON.10.104}},
volume = {{6}},
year = {{2010}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: