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Equine nasal mucosal explants, a valuable tool to study early events of the pathogenesis of equine herpesvirus infections

(2011)
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Abstract
Equine herpesvirus 1 (EHV-1) is an important respiratory pathogen, causing major losses in the horse industry worldwide. These losses can be mainly attributed to abortion, neonatal foal death and fatal equine herpes myeloencephalopathy (EHM). EHM outbreaks, mainly caused by neurovirulent EHV-1 isolates, have been reported with increasing frequency throughout North America and Europe, resulting in its classification as a potentially emerging disease by the United States Department of Agriculture’s Animal and Plant Health Inspection Service (USDA APHIS, 2007). Another major problem is the incapability of the currently existing vaccines to fully prevent abortion and EHM. A further complication are the financial and ethical difficulties that surround in vivo experiments in horses, hereby hampering research on EHV-1 in its natural host, the horse. The development of an in vitro model using upper respiratory tract (URT) tissues, which closely resembles the in vivo situation in the horse would facilitate research and lead to better insights in the pathogenesis of respiratory pathogens in the horse, such as EHV-1 and the closely related equine herpesvirus 4 (EHV-4). By means of such in vitro model, replication characteristics of neurovirulent and non-neurovirulent isolates of EHV-1 could be assessed which could shed more light on their behavior at the level of the URT. The explants model could furthermore be used to screen mutant viruses for their suitability as a vaccine candidate.
Keywords
Horse, Replication, Nasal mucosal explants, Equine herpesviruses

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Citation

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Chicago
Vandekerckhove, Annelies. 2011. “Equine Nasal Mucosal Explants, a Valuable Tool to Study Early Events of the Pathogenesis of Equine Herpesvirus Infections”. Merelbeke, Belgium: Ghent University. Faculty of Veterinary Medicine.
APA
Vandekerckhove, Annelies. (2011). Equine nasal mucosal explants, a valuable tool to study early events of the pathogenesis of equine herpesvirus infections. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vancouver
1.
Vandekerckhove A. Equine nasal mucosal explants, a valuable tool to study early events of the pathogenesis of equine herpesvirus infections. [Merelbeke, Belgium]: Ghent University. Faculty of Veterinary Medicine; 2011.
MLA
Vandekerckhove, Annelies. “Equine Nasal Mucosal Explants, a Valuable Tool to Study Early Events of the Pathogenesis of Equine Herpesvirus Infections.” 2011 : n. pag. Print.
@phdthesis{1187433,
  abstract     = {Equine herpesvirus 1 (EHV-1) is an important respiratory pathogen, causing major losses in the horse industry worldwide. These losses can be mainly attributed to abortion, neonatal foal death and fatal equine herpes myeloencephalopathy (EHM). EHM outbreaks, mainly caused by neurovirulent EHV-1 isolates, have been reported with increasing frequency throughout North America and Europe, resulting in its classification as a potentially emerging disease by the United States Department of Agriculture{\textquoteright}s Animal and Plant Health Inspection Service (USDA APHIS, 2007). Another major problem is the incapability of the currently existing vaccines to fully prevent abortion and EHM. A further complication are the financial and ethical difficulties that surround in vivo experiments in horses, hereby hampering research on EHV-1 in its natural host, the horse. The development of an in vitro model using upper respiratory tract (URT) tissues, which closely resembles the in vivo situation in the horse would facilitate research and lead to better insights in the pathogenesis of respiratory pathogens in the horse, such as EHV-1 and the closely related equine herpesvirus 4 (EHV-4). By means of such in vitro model, replication characteristics of neurovirulent and non-neurovirulent isolates of EHV-1 could be assessed which could shed more light on their behavior at the level of the URT. The explants model could furthermore be used to screen mutant viruses for their suitability as a vaccine candidate.},
  author       = {Vandekerckhove, Annelies},
  isbn         = {9789058642479},
  keyword      = {Horse,Replication,Nasal mucosal explants,Equine herpesviruses},
  language     = {eng},
  pages        = {173},
  publisher    = {Ghent University. Faculty of Veterinary Medicine},
  school       = {Ghent University},
  title        = {Equine nasal mucosal explants, a valuable tool to study early events of the pathogenesis of equine herpesvirus infections},
  year         = {2011},
}