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New insights into the evolution of metazoan cadherins

Paco Hulpiau and Frans Van Roy UGent (2011) MOLECULAR BIOLOGY AND EVOLUTION. 28(1). p.647-657
abstract
Mining newly sequenced genomes of basal metazoan organisms reveals the evolutionary origin of modern protein families. Specific cell-cell adhesion and intracellular communication are key processes in multicellular animals, and members of the cadherin superfamily are essential players in these processes. Mammalian genomes contain over 100 genes belonging to this superfamily. By a combination of tBLASTn and profile hidden Markov model analyses, we made an exhaustive search for cadherins and compiled the cadherin repertoires in key organisms, including Branchiostoma floridae (amphioxus), the sea anemone Nematostella vectensis, and the placozoan Trichoplax adhaerens. Comparative analyses of multiple protein domains within known and novel cadherins enabled us to reconstruct the complex evolution in metazoa of this large superfamily. Five main cadherin branches are represented in the primitive metazoan Trichoplax: classical (CDH), flamingo (CELSR), dachsous (DCHS), FAT, and FAT-like. Classical cadherins, such as E-cadherin, arose from an Urmetazoan cadherin, which progressively lost N-terminal extracellular cadherin repeats, whereas its cytoplasmic domain, which binds the armadillo proteins p120ctn and beta-catenin, remained quite conserved from placozoa to man. The origin of protocadherins predates the Bilateria and is likely rooted in an ancestral FAT cadherin. Several but not all protostomians lost protocadherins. The emergence of chordates coincided with a great expansion of the protocadherin repertoire. The evolution of ancient metazoan cadherins points to their unique and crucial roles in multicellular animal life.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
protocadherins, key organisms, cadherins, metazoan evolution, protein superfamily, PLANAR CELL POLARITY, PROTOCADHERIN FAMILY, CLASSIC CADHERINS, SUPERFAMILY, GENOME, GENE, IDENTIFICATION, ADHESION, DATABASE, REVEALS
journal title
MOLECULAR BIOLOGY AND EVOLUTION
Mol. Biol. Evol.
volume
28
issue
1
pages
647 - 657
Web of Science type
Article
Web of Science id
000285418600062
JCR category
EVOLUTIONARY BIOLOGY
JCR impact factor
5.55 (2011)
JCR rank
4/45 (2011)
JCR quartile
1 (2011)
ISSN
0737-4038
DOI
10.1093/molbev/msq233
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1187326
handle
http://hdl.handle.net/1854/LU-1187326
date created
2011-03-14 12:27:10
date last changed
2016-12-19 15:45:14
@article{1187326,
  abstract     = {Mining newly sequenced genomes of basal metazoan organisms reveals the evolutionary origin of modern protein families. Specific cell-cell adhesion and intracellular communication are key processes in multicellular animals, and members of the cadherin superfamily are essential players in these processes. Mammalian genomes contain over 100 genes belonging to this superfamily. By a combination of tBLASTn and profile hidden Markov model analyses, we made an exhaustive search for cadherins and compiled the cadherin repertoires in key organisms, including Branchiostoma floridae (amphioxus), the sea anemone Nematostella vectensis, and the placozoan Trichoplax adhaerens. Comparative analyses of multiple protein domains within known and novel cadherins enabled us to reconstruct the complex evolution in metazoa of this large superfamily. Five main cadherin branches are represented in the primitive metazoan Trichoplax: classical (CDH), flamingo (CELSR), dachsous (DCHS), FAT, and FAT-like. Classical cadherins, such as E-cadherin, arose from an Urmetazoan cadherin, which progressively lost N-terminal extracellular cadherin repeats, whereas its cytoplasmic domain, which binds the armadillo proteins p120ctn and beta-catenin, remained quite conserved from placozoa to man. The origin of protocadherins predates the Bilateria and is likely rooted in an ancestral FAT cadherin. Several but not all protostomians lost protocadherins. The emergence of chordates coincided with a great expansion of the protocadherin repertoire. The evolution of ancient metazoan cadherins points to their unique and crucial roles in multicellular animal life.},
  author       = {Hulpiau, Paco and Van Roy, Frans},
  issn         = {0737-4038},
  journal      = {MOLECULAR BIOLOGY AND EVOLUTION},
  keyword      = {protocadherins,key organisms,cadherins,metazoan evolution,protein superfamily,PLANAR CELL POLARITY,PROTOCADHERIN FAMILY,CLASSIC CADHERINS,SUPERFAMILY,GENOME,GENE,IDENTIFICATION,ADHESION,DATABASE,REVEALS},
  language     = {eng},
  number       = {1},
  pages        = {647--657},
  title        = {New insights into the evolution of metazoan cadherins},
  url          = {http://dx.doi.org/10.1093/molbev/msq233},
  volume       = {28},
  year         = {2011},
}

Chicago
Hulpiau, Paco, and Frans Van Roy. 2011. “New Insights into the Evolution of Metazoan Cadherins.” Molecular Biology and Evolution 28 (1): 647–657.
APA
Hulpiau, P., & Van Roy, F. (2011). New insights into the evolution of metazoan cadherins. MOLECULAR BIOLOGY AND EVOLUTION, 28(1), 647–657.
Vancouver
1.
Hulpiau P, Van Roy F. New insights into the evolution of metazoan cadherins. MOLECULAR BIOLOGY AND EVOLUTION. 2011;28(1):647–57.
MLA
Hulpiau, Paco, and Frans Van Roy. “New Insights into the Evolution of Metazoan Cadherins.” MOLECULAR BIOLOGY AND EVOLUTION 28.1 (2011): 647–657. Print.