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Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients

Kim De Ruyck UGent, Kristiaan Nackaerts, Laurence Beels UGent, Joke Werbrouck UGent, Annick De Volder, Marc Meysman, Bihiyga Salhi UGent, Jan Van Meerbeeck UGent and Hubert Thierens UGent (2010) PHARMACOGENOMICS. 11(8). p.1053-1063
abstract
Aims: This study evaluates the relationship of six polymorphisms found in the CHRNA3, DRD2 and COMT genes with nicotine dependence, the ability to quit smoking and the occurrence of withdrawal symptoms after short-term use of nicotine patch in hospitalized patients. Materials & methods: The study included 233 participants from a double-blind, placebo-controlled trial of nicotine patch substitution with a 6-month follow-up period. Nicotine dependence was assessed by the Fagerstrom Test for Nicotine Dependence (FTND) questionnaire, withdrawal symptoms by the Minnesota Nicotine Withdrawal Scale questionnaire and smoking cessation by self-reported abstinence at 1 week, 1 month and 6 months after treatment. Results: After correcting for multiple testing, three polymorphisms in the DRD2 gene (Taq1A, Taq1B and Pro319Pro) were significantly associated with nicotine dependence (p = 0.018, p = 0.048 and p = 0.006, respectively). Using a cutoff point for the FIND score, the CHRNA3 Tyr215Tyr (rs1051730) polymorphism was also associated with nicotine dependence (p = 0.037 and p = 0.074 after correction for multiple testing). No association of any of the studied polymorphisms was observed with either smoking cessation or the occurrence of withdrawal symptoms. Conclusion: This study confirms the reported association of the CHRNA3 locus with nicotine dependence and shows the involvement of two independent DRD2 polymorphisms in nicotine dependence.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
REPLACEMENT THERAPY, CIGARETTE-SMOKING, FUNCTIONAL POLYMORPHISM, GENOME-WIDE ASSOCIATION, THERAPY RANDOMIZED-TRIAL, D2 RECEPTOR GENE, CATECHOL-O-METHYLTRANSFERASE, withdrawal, smoking cessation, nicotine dependence, polymorphism, HEAVY SMOKING, MOLECULAR-GENETICS, TAQ1A POLYMORPHISM, DRD2, COMT, CHRNA3
journal title
PHARMACOGENOMICS
Pharmacogenomics
volume
11
issue
8
pages
1053 - 1063
Web of Science type
Article
Web of Science id
000281465500011
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
3.876 (2010)
JCR rank
44/249 (2010)
JCR quartile
1 (2010)
ISSN
1462-2416
DOI
10.2217/pgs.10.75
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1186568
handle
http://hdl.handle.net/1854/LU-1186568
date created
2011-03-11 15:20:23
date last changed
2012-06-08 14:49:57
@article{1186568,
  abstract     = {Aims: This study evaluates the relationship of six polymorphisms found in the CHRNA3, DRD2 and COMT genes with nicotine dependence, the ability to quit smoking and the occurrence of withdrawal symptoms after short-term use of nicotine patch in hospitalized patients.
Materials \& methods: The study included 233 participants from a double-blind, placebo-controlled trial of nicotine patch substitution with a 6-month follow-up period. Nicotine dependence was assessed by the Fagerstrom Test for Nicotine Dependence (FTND) questionnaire, withdrawal symptoms by the Minnesota Nicotine Withdrawal Scale questionnaire and smoking cessation by self-reported abstinence at 1 week, 1 month and 6 months after treatment.
Results: After correcting for multiple testing, three polymorphisms in the DRD2 gene (Taq1A, Taq1B and Pro319Pro) were significantly associated with nicotine dependence (p = 0.018, p = 0.048 and p = 0.006, respectively). Using a cutoff point for the FIND score, the CHRNA3 Tyr215Tyr (rs1051730) polymorphism was also associated with nicotine dependence (p = 0.037 and p = 0.074 after correction for multiple testing). No association of any of the studied polymorphisms was observed with either smoking cessation or the occurrence of withdrawal symptoms.
Conclusion: This study confirms the reported association of the CHRNA3 locus with nicotine dependence and shows the involvement of two independent DRD2 polymorphisms in nicotine dependence.},
  author       = {De Ruyck, Kim and Nackaerts, Kristiaan and Beels, Laurence and Werbrouck, Joke and De Volder, Annick and Meysman, Marc and Salhi, Bihiyga and Van Meerbeeck, Jan and Thierens, Hubert},
  issn         = {1462-2416},
  journal      = {PHARMACOGENOMICS},
  keyword      = {REPLACEMENT THERAPY,CIGARETTE-SMOKING,FUNCTIONAL POLYMORPHISM,GENOME-WIDE ASSOCIATION,THERAPY RANDOMIZED-TRIAL,D2 RECEPTOR GENE,CATECHOL-O-METHYLTRANSFERASE,withdrawal,smoking cessation,nicotine dependence,polymorphism,HEAVY SMOKING,MOLECULAR-GENETICS,TAQ1A POLYMORPHISM,DRD2,COMT,CHRNA3},
  language     = {eng},
  number       = {8},
  pages        = {1053--1063},
  title        = {Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients},
  url          = {http://dx.doi.org/10.2217/pgs.10.75},
  volume       = {11},
  year         = {2010},
}

Chicago
De Ruyck, Kim, Kristiaan Nackaerts, Laurence Beels, Joke Werbrouck, Annick De Volder, Marc Meysman, Bihiyga Salhi, Jan Van Meerbeeck, and Hubert Thierens. 2010. “Genetic Variation in Three Candidate Genes and Nicotine Dependence, Withdrawal and Smoking Cessation in Hospitalized Patients.” Pharmacogenomics 11 (8): 1053–1063.
APA
De Ruyck, Kim, Nackaerts, K., Beels, L., Werbrouck, J., De Volder, A., Meysman, M., Salhi, B., et al. (2010). Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. PHARMACOGENOMICS, 11(8), 1053–1063.
Vancouver
1.
De Ruyck K, Nackaerts K, Beels L, Werbrouck J, De Volder A, Meysman M, et al. Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. PHARMACOGENOMICS. 2010;11(8):1053–63.
MLA
De Ruyck, Kim, Kristiaan Nackaerts, Laurence Beels, et al. “Genetic Variation in Three Candidate Genes and Nicotine Dependence, Withdrawal and Smoking Cessation in Hospitalized Patients.” PHARMACOGENOMICS 11.8 (2010): 1053–1063. Print.