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Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients

(2010) PHARMACOGENOMICS. 11(8). p.1053-1063
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Abstract
Aims: This study evaluates the relationship of six polymorphisms found in the CHRNA3, DRD2 and COMT genes with nicotine dependence, the ability to quit smoking and the occurrence of withdrawal symptoms after short-term use of nicotine patch in hospitalized patients. Materials & methods: The study included 233 participants from a double-blind, placebo-controlled trial of nicotine patch substitution with a 6-month follow-up period. Nicotine dependence was assessed by the Fagerstrom Test for Nicotine Dependence (FTND) questionnaire, withdrawal symptoms by the Minnesota Nicotine Withdrawal Scale questionnaire and smoking cessation by self-reported abstinence at 1 week, 1 month and 6 months after treatment. Results: After correcting for multiple testing, three polymorphisms in the DRD2 gene (Taq1A, Taq1B and Pro319Pro) were significantly associated with nicotine dependence (p = 0.018, p = 0.048 and p = 0.006, respectively). Using a cutoff point for the FIND score, the CHRNA3 Tyr215Tyr (rs1051730) polymorphism was also associated with nicotine dependence (p = 0.037 and p = 0.074 after correction for multiple testing). No association of any of the studied polymorphisms was observed with either smoking cessation or the occurrence of withdrawal symptoms. Conclusion: This study confirms the reported association of the CHRNA3 locus with nicotine dependence and shows the involvement of two independent DRD2 polymorphisms in nicotine dependence.
Keywords
REPLACEMENT THERAPY, CIGARETTE-SMOKING, FUNCTIONAL POLYMORPHISM, GENOME-WIDE ASSOCIATION, THERAPY RANDOMIZED-TRIAL, D2 RECEPTOR GENE, CATECHOL-O-METHYLTRANSFERASE, withdrawal, smoking cessation, nicotine dependence, polymorphism, HEAVY SMOKING, MOLECULAR-GENETICS, TAQ1A POLYMORPHISM, DRD2, COMT, CHRNA3

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Chicago
De Ruyck, Kim, Kristiaan Nackaerts, Laurence Beels, Joke Werbrouck, Annick De Volder, Marc Meysman, Bihiyga Salhi, Jan Van Meerbeeck, and Hubert Thierens. 2010. “Genetic Variation in Three Candidate Genes and Nicotine Dependence, Withdrawal and Smoking Cessation in Hospitalized Patients.” Pharmacogenomics 11 (8): 1053–1063.
APA
De Ruyck, Kim, Nackaerts, K., Beels, L., Werbrouck, J., De Volder, A., Meysman, M., Salhi, B., et al. (2010). Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. PHARMACOGENOMICS, 11(8), 1053–1063.
Vancouver
1.
De Ruyck K, Nackaerts K, Beels L, Werbrouck J, De Volder A, Meysman M, et al. Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. PHARMACOGENOMICS. 2010;11(8):1053–63.
MLA
De Ruyck, Kim, Kristiaan Nackaerts, Laurence Beels, et al. “Genetic Variation in Three Candidate Genes and Nicotine Dependence, Withdrawal and Smoking Cessation in Hospitalized Patients.” PHARMACOGENOMICS 11.8 (2010): 1053–1063. Print.
@article{1186568,
  abstract     = {Aims: This study evaluates the relationship of six polymorphisms found in the CHRNA3, DRD2 and COMT genes with nicotine dependence, the ability to quit smoking and the occurrence of withdrawal symptoms after short-term use of nicotine patch in hospitalized patients.
Materials \& methods: The study included 233 participants from a double-blind, placebo-controlled trial of nicotine patch substitution with a 6-month follow-up period. Nicotine dependence was assessed by the Fagerstrom Test for Nicotine Dependence (FTND) questionnaire, withdrawal symptoms by the Minnesota Nicotine Withdrawal Scale questionnaire and smoking cessation by self-reported abstinence at 1 week, 1 month and 6 months after treatment.
Results: After correcting for multiple testing, three polymorphisms in the DRD2 gene (Taq1A, Taq1B and Pro319Pro) were significantly associated with nicotine dependence (p = 0.018, p = 0.048 and p = 0.006, respectively). Using a cutoff point for the FIND score, the CHRNA3 Tyr215Tyr (rs1051730) polymorphism was also associated with nicotine dependence (p = 0.037 and p = 0.074 after correction for multiple testing). No association of any of the studied polymorphisms was observed with either smoking cessation or the occurrence of withdrawal symptoms.
Conclusion: This study confirms the reported association of the CHRNA3 locus with nicotine dependence and shows the involvement of two independent DRD2 polymorphisms in nicotine dependence.},
  author       = {De Ruyck, Kim and Nackaerts, Kristiaan and Beels, Laurence and Werbrouck, Joke and De Volder, Annick and Meysman, Marc and Salhi, Bihiyga and Van Meerbeeck, Jan and Thierens, Hubert},
  issn         = {1462-2416},
  journal      = {PHARMACOGENOMICS},
  keyword      = {REPLACEMENT THERAPY,CIGARETTE-SMOKING,FUNCTIONAL POLYMORPHISM,GENOME-WIDE ASSOCIATION,THERAPY RANDOMIZED-TRIAL,D2 RECEPTOR GENE,CATECHOL-O-METHYLTRANSFERASE,withdrawal,smoking cessation,nicotine dependence,polymorphism,HEAVY SMOKING,MOLECULAR-GENETICS,TAQ1A POLYMORPHISM,DRD2,COMT,CHRNA3},
  language     = {eng},
  number       = {8},
  pages        = {1053--1063},
  title        = {Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients},
  url          = {http://dx.doi.org/10.2217/pgs.10.75},
  volume       = {11},
  year         = {2010},
}

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