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Early arterial revascularization after hepatic artery thrombosis may avoid graft loss and improve outcomes in adult liver transplantation

Andrea Scarinci UGent, MAURICIO SAINZ-BARRIGA UGent, Frederik Berrevoet UGent, B van den Bossche, Isabelle Colle UGent, Anja Geerts UGent, Xavier Rogiers UGent, Hans Van Vlierberghe UGent, Bernard de Hemptinne and Roberto Troisi UGent (2010) TRANSPLANTATION PROCEEDINGS. 42(10). p.4403-4408
abstract
Background. Hepatic artery thrombosis (HAT) represents a devastating complication after liver transplantation (LT), occurring in 1.6%-9.2% of adult recipients. Treatments of HAT include thrombectomy and thrombolysis (with or without redo of the arterial anastomosis), percutaneous thrombolysis through an angiogram, liver retransplantation, and clinical observation. Methods. We retrospectively analyzed data from 739 adult LTs between January 1992 and September 2009. HAT was classified as early (E-HAT), when occurring within the first 30 days after LT, or late HAT (L-HAT), when diagnosed from the 2nd month onward. HAT suspected clinically was confirmed by Doppler ultrasound and angiography in all cases. Attempted revascularization was defined as early (ER) if performed within the first 2 weeks after LT and late (LR) if performed between 15 and 30 days. Results. After a median follow-up (FU) of 62 months (range, 1-227 months), HAT occurred in 31/739 grafts (4.3%). E-HAT was recorded in 25/31 cases (3.4%) and L-HAT in 11/31 eases (0.8%). ER was performed in 20/31 patients (65%) leading to 62% graft salvage; it was 81% when the revascularization was performed within the first week after LT (P = ns). LR was unsuccessful in all cases (P = .08). The overall incidence of BC among rescued grafts was 54% without graft loss during FU. Graft survival was 79% versus 71%; and 50% versus 50% at 1 and 3 years for E-HAT and L-HAT, respectively (P = ns). Conclusions. Urgent revascularization in cases of early HAT may decrease graft loss, especially when performed within the first week after LT, with improved overall outcomes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (proceedingsPaper)
publication status
published
subject
keyword
EXPERIENCE, SONOGRAPHY, MANAGEMENT, SERIES, DIAGNOSIS, VASCULAR COMPLICATIONS
journal title
TRANSPLANTATION PROCEEDINGS
Transplant. Proc.
volume
42
issue
10
pages
4403 - 4408
conference name
23rd International congress of the Transplantation Society
conference location
Vancouver, BC, Canada
conference start
2010-08-15
conference end
2010-08-19
Web of Science type
Proceedings Paper
Web of Science id
000285732200125
JCR category
SURGERY
JCR impact factor
0.993 (2010)
JCR rank
116/186 (2010)
JCR quartile
3 (2010)
ISSN
0041-1345
DOI
10.1016/j.transproceed.2010.07.014
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1186157
handle
http://hdl.handle.net/1854/LU-1186157
date created
2011-03-11 10:52:03
date last changed
2016-12-19 15:46:42
@article{1186157,
  abstract     = {Background. Hepatic artery thrombosis (HAT) represents a devastating complication after liver transplantation (LT), occurring in 1.6\%-9.2\% of adult recipients. Treatments of HAT include thrombectomy and thrombolysis (with or without redo of the arterial anastomosis), percutaneous thrombolysis through an angiogram, liver retransplantation, and clinical observation.
Methods. We retrospectively analyzed data from 739 adult LTs between January 1992 and September 2009. HAT was classified as early (E-HAT), when occurring within the first 30 days after LT, or late HAT (L-HAT), when diagnosed from the 2nd month onward. HAT suspected clinically was confirmed by Doppler ultrasound and angiography in all cases. Attempted revascularization was defined as early (ER) if performed within the first 2 weeks after LT and late (LR) if performed between 15 and 30 days.
Results. After a median follow-up (FU) of 62 months (range, 1-227 months), HAT occurred in 31/739 grafts (4.3\%). E-HAT was recorded in 25/31 cases (3.4\%) and L-HAT in 11/31 eases (0.8\%). ER was performed in 20/31 patients (65\%) leading to 62\% graft salvage; it was 81\% when the revascularization was performed within the first week after LT (P = ns). LR was unsuccessful in all cases (P = .08). The overall incidence of BC among rescued grafts was 54\% without graft loss during FU. Graft survival was 79\% versus 71\%; and 50\% versus 50\% at 1 and 3 years for E-HAT and L-HAT, respectively (P = ns).
Conclusions. Urgent revascularization in cases of early HAT may decrease graft loss, especially when performed within the first week after LT, with improved overall outcomes.},
  author       = {Scarinci, Andrea and SAINZ-BARRIGA, MAURICIO and Berrevoet, Frederik and van den Bossche, B and Colle, Isabelle and Geerts, Anja and Rogiers, Xavier and Van Vlierberghe, Hans and de Hemptinne, Bernard and Troisi, Roberto},
  issn         = {0041-1345},
  journal      = {TRANSPLANTATION PROCEEDINGS},
  keyword      = {EXPERIENCE,SONOGRAPHY,MANAGEMENT,SERIES,DIAGNOSIS,VASCULAR COMPLICATIONS},
  language     = {eng},
  location     = {Vancouver, BC, Canada},
  number       = {10},
  pages        = {4403--4408},
  title        = {Early arterial revascularization after hepatic artery thrombosis may avoid graft loss and improve outcomes in adult liver transplantation},
  url          = {http://dx.doi.org/10.1016/j.transproceed.2010.07.014},
  volume       = {42},
  year         = {2010},
}

Chicago
Scarinci, Andrea, MAURICIO SAINZ-BARRIGA, Frederik Berrevoet, B van den Bossche, Isabelle Colle, Anja Geerts, Xavier Rogiers, Hans Van Vlierberghe, Bernard de Hemptinne, and Roberto Troisi. 2010. “Early Arterial Revascularization After Hepatic Artery Thrombosis May Avoid Graft Loss and Improve Outcomes in Adult Liver Transplantation.” Transplantation Proceedings 42 (10): 4403–4408.
APA
Scarinci, A., SAINZ-BARRIGA, M., Berrevoet, F., van den Bossche, B., Colle, I., Geerts, A., Rogiers, X., et al. (2010). Early arterial revascularization after hepatic artery thrombosis may avoid graft loss and improve outcomes in adult liver transplantation. TRANSPLANTATION PROCEEDINGS, 42(10), 4403–4408. Presented at the 23rd International congress of the Transplantation Society.
Vancouver
1.
Scarinci A, SAINZ-BARRIGA M, Berrevoet F, van den Bossche B, Colle I, Geerts A, et al. Early arterial revascularization after hepatic artery thrombosis may avoid graft loss and improve outcomes in adult liver transplantation. TRANSPLANTATION PROCEEDINGS. 2010;42(10):4403–8.
MLA
Scarinci, Andrea, MAURICIO SAINZ-BARRIGA, Frederik Berrevoet, et al. “Early Arterial Revascularization After Hepatic Artery Thrombosis May Avoid Graft Loss and Improve Outcomes in Adult Liver Transplantation.” TRANSPLANTATION PROCEEDINGS 42.10 (2010): 4403–4408. Print.