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Emerging inflammasome effector mechanisms

(2011) NATURE REVIEWS IMMUNOLOGY. 11(3). p.213-220
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Abstract
Caspase 1 activation by inflammasome complexes in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) induces the maturation and secretion of the pro-inflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18. Recent reports have begun to identify additional inflammasome effector mechanisms that proceed independently of IL-1 beta and IL-18. These include the induction of pyroptotic cell death, the restriction of bacterial replication, the activation of lipid metabolic pathways for cell repair and the secretion of DAMPs and leaderless cytokines. These non-canonical functions of caspase 1 illustrate the diverse mechanisms by which inflammasomes might contribute to innate immunity, repair responses and host defence.
Keywords
INFECTED MACROPHAGES, CUTTING EDGE, LISTERIA-MONOCYTOGENES, PORE-FORMING TOXINS, CASPASE-1 ACTIVATION, NLRP3 INFLAMMASOME, FRANCISELLA-TULARENSIS, GAMMA-INDUCING FACTOR, UNCONVENTIONAL PROTEIN SECRETION, INTERLEUKIN-1-BETA CONVERTING-ENZYME

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Citation

Please use this url to cite or link to this publication:

Chicago
Lamkanfi, Mohamed. 2011. “Emerging Inflammasome Effector Mechanisms.” Nature Reviews Immunology 11 (3): 213–220.
APA
Lamkanfi, M. (2011). Emerging inflammasome effector mechanisms. NATURE REVIEWS IMMUNOLOGY, 11(3), 213–220.
Vancouver
1.
Lamkanfi M. Emerging inflammasome effector mechanisms. NATURE REVIEWS IMMUNOLOGY. 2011;11(3):213–20.
MLA
Lamkanfi, Mohamed. “Emerging Inflammasome Effector Mechanisms.” NATURE REVIEWS IMMUNOLOGY 11.3 (2011): 213–220. Print.
@article{1186142,
  abstract     = {Caspase 1 activation by inflammasome complexes in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) induces the maturation and secretion of the pro-inflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18. Recent reports have begun to identify additional inflammasome effector mechanisms that proceed independently of IL-1 beta and IL-18. These include the induction of pyroptotic cell death, the restriction of bacterial replication, the activation of lipid metabolic pathways for cell repair and the secretion of DAMPs and leaderless cytokines. These non-canonical functions of caspase 1 illustrate the diverse mechanisms by which inflammasomes might contribute to innate immunity, repair responses and host defence.},
  author       = {Lamkanfi, Mohamed},
  issn         = {1474-1733},
  journal      = {NATURE REVIEWS IMMUNOLOGY},
  keywords     = {INFECTED MACROPHAGES,CUTTING EDGE,LISTERIA-MONOCYTOGENES,PORE-FORMING TOXINS,CASPASE-1 ACTIVATION,NLRP3 INFLAMMASOME,FRANCISELLA-TULARENSIS,GAMMA-INDUCING FACTOR,UNCONVENTIONAL PROTEIN SECRETION,INTERLEUKIN-1-BETA CONVERTING-ENZYME},
  language     = {eng},
  number       = {3},
  pages        = {213--220},
  title        = {Emerging inflammasome effector mechanisms},
  url          = {http://dx.doi.org/10.1038/nri2936},
  volume       = {11},
  year         = {2011},
}

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