The impact of concomitant rhinitis on asthma-related quality of life and asthma control
- Author
- O Vandenplas, M Dramaix, Guy Joos (UGent) , R Louis, A Michils, G Verleden, W Vincken, AM Vints, E Herbots and Claus Bachert (UGent)
- Organization
- Abstract
- Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity.
- Keywords
- GA(2)LEN, NONALLERGIC RHINITIS, CORRELATE, EMERGENCY, VALIDATION, RISK, QUESTIONNAIRE, PREVALENCE, CLASSIFICATION, quality of life, asthma, ALLERGIC RHINITIS, rhinitis
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1184362
- MLA
- Vandenplas, O., et al. “The Impact of Concomitant Rhinitis on Asthma-Related Quality of Life and Asthma Control.” ALLERGY, vol. 65, no. 10, 2010, pp. 1290–97, doi:10.1111/j.1398-9995.2010.02365.x.
- APA
- Vandenplas, O., Dramaix, M., Joos, G., Louis, R., Michils, A., Verleden, G., … Bachert, C. (2010). The impact of concomitant rhinitis on asthma-related quality of life and asthma control. ALLERGY, 65(10), 1290–1297. https://doi.org/10.1111/j.1398-9995.2010.02365.x
- Chicago author-date
- Vandenplas, O, M Dramaix, Guy Joos, R Louis, A Michils, G Verleden, W Vincken, AM Vints, E Herbots, and Claus Bachert. 2010. “The Impact of Concomitant Rhinitis on Asthma-Related Quality of Life and Asthma Control.” ALLERGY 65 (10): 1290–97. https://doi.org/10.1111/j.1398-9995.2010.02365.x.
- Chicago author-date (all authors)
- Vandenplas, O, M Dramaix, Guy Joos, R Louis, A Michils, G Verleden, W Vincken, AM Vints, E Herbots, and Claus Bachert. 2010. “The Impact of Concomitant Rhinitis on Asthma-Related Quality of Life and Asthma Control.” ALLERGY 65 (10): 1290–1297. doi:10.1111/j.1398-9995.2010.02365.x.
- Vancouver
- 1.Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, et al. The impact of concomitant rhinitis on asthma-related quality of life and asthma control. ALLERGY. 2010;65(10):1290–7.
- IEEE
- [1]O. Vandenplas et al., “The impact of concomitant rhinitis on asthma-related quality of life and asthma control,” ALLERGY, vol. 65, no. 10, pp. 1290–1297, 2010.
@article{1184362, abstract = {{Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity.}}, author = {{Vandenplas, O and Dramaix, M and Joos, Guy and Louis, R and Michils, A and Verleden, G and Vincken, W and Vints, AM and Herbots, E and Bachert, Claus}}, issn = {{0105-4538}}, journal = {{ALLERGY}}, keywords = {{GA(2)LEN,NONALLERGIC RHINITIS,CORRELATE,EMERGENCY,VALIDATION,RISK,QUESTIONNAIRE,PREVALENCE,CLASSIFICATION,quality of life,asthma,ALLERGIC RHINITIS,rhinitis}}, language = {{eng}}, number = {{10}}, pages = {{1290--1297}}, title = {{The impact of concomitant rhinitis on asthma-related quality of life and asthma control}}, url = {{http://doi.org/10.1111/j.1398-9995.2010.02365.x}}, volume = {{65}}, year = {{2010}}, }
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