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The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease

Nele Pauwels (UGent) , Ken Bracke (UGent) , Tania Maes (UGent) , Charles Pilette, Guy Joos (UGent) and Guy Brusselle (UGent)
(2010) EXPERIMENTAL LUNG RESEARCH. 36(8). p.469-483
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Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and extrapulmonary manifestations including systemic inflammation and weight loss. Increased levels of interleukin-6 (IL-6) have been demonstrated in sputum and serum of COPD patients. Therefore, the authors investigated the in vivo role of IL-6 in a murine model of COPD. Wild-type (WT) and IL-6 knockout (KO) mice were exposed subacutely (4 weeks) and chronically (24 weeks) to air or cigarette smoke (CS). Subacute and chronic CS exposure significantly increased pulmonary IL-6 mRNA expression in lung tissue and IL-6 protein levels in bronchoalveolar lavage fluid of WT mice. However, CS-induced accumulation of inflammatory cells at both time points and lymphoid aggregate formation upon chronic CS exposure were independent of IL-6. Chonic CS exposure was associated with a significant failure to gain weight in both WT mice and IL-6 KO mice. Remarkably, air-exposed IL-6 KO mice have lower body weight, serum leptin levels, and adipose tissue mass compared to air-exposed WT mice. In conclusion, IL-6 is of minor importance in CS-induced pulmonary and systemic manifestations in mice, but this study confirms the role for IL-6 as regulator of body weight and body composition
Keywords
interleukin-6, IL-6 GENE, IN-VIVO, C-REACTIVE PROTEIN, INFLAMMATION, MICE, COPD, CELL, EMPHYSEMA, RESISTANCE, systemic inflammation, pulmonary inflammation, NECROSIS-FACTOR-ALPHA

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Chicago
Pauwels, Nele, Ken Bracke, Tania Maes, Charles Pilette, Guy Joos, and Guy Brusselle. 2010. “The Role of Interleukin-6 in Pulmonary and Systemic Manifestations in a Murine Model of Chronic Obstructive Pulmonary Disease.” Experimental Lung Research 36 (8): 469–483.
APA
Pauwels, Nele, Bracke, K., Maes, T., Pilette, C., Joos, G., & Brusselle, G. (2010). The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease. EXPERIMENTAL LUNG RESEARCH, 36(8), 469–483.
Vancouver
1.
Pauwels N, Bracke K, Maes T, Pilette C, Joos G, Brusselle G. The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease. EXPERIMENTAL LUNG RESEARCH. 2010;36(8):469–83.
MLA
Pauwels, Nele, Ken Bracke, Tania Maes, et al. “The Role of Interleukin-6 in Pulmonary and Systemic Manifestations in a Murine Model of Chronic Obstructive Pulmonary Disease.” EXPERIMENTAL LUNG RESEARCH 36.8 (2010): 469–483. Print.
@article{1184334,
  abstract     = {Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and extrapulmonary manifestations including systemic inflammation and weight loss. Increased levels of interleukin-6 (IL-6) have been demonstrated in sputum and serum of COPD patients. Therefore, the authors investigated the in vivo role of IL-6 in a murine model of COPD. Wild-type (WT) and IL-6 knockout (KO) mice were exposed subacutely (4 weeks) and chronically (24 weeks) to air or cigarette smoke (CS). Subacute and chronic CS exposure significantly increased pulmonary IL-6 mRNA expression in lung tissue and IL-6 protein levels in bronchoalveolar lavage fluid of WT mice. However, CS-induced accumulation of inflammatory cells at both time points and lymphoid aggregate formation upon chronic CS exposure were independent of IL-6. Chonic CS exposure was associated with a significant failure to gain weight in both WT mice and IL-6 KO mice. Remarkably, air-exposed IL-6 KO mice have lower body weight, serum leptin levels, and adipose tissue mass compared to air-exposed WT mice. In conclusion, IL-6 is of minor importance in CS-induced pulmonary and systemic manifestations in mice, but this study confirms the role for IL-6 as regulator of body weight and body composition},
  author       = {Pauwels, Nele and Bracke, Ken and Maes, Tania and Pilette, Charles and Joos, Guy and Brusselle, Guy},
  issn         = {0190-2148},
  journal      = {EXPERIMENTAL LUNG RESEARCH},
  keyword      = {interleukin-6,IL-6 GENE,IN-VIVO,C-REACTIVE PROTEIN,INFLAMMATION,MICE,COPD,CELL,EMPHYSEMA,RESISTANCE,systemic inflammation,pulmonary inflammation,NECROSIS-FACTOR-ALPHA},
  language     = {eng},
  number       = {8},
  pages        = {469--483},
  title        = {The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease},
  url          = {http://dx.doi.org/10.3109/01902141003739723},
  volume       = {36},
  year         = {2010},
}

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