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The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease

Nele Pauwels UGent, Ken Bracke UGent, Tania Maes UGent, Charles Pilette, Guy Joos UGent and Guy Brusselle UGent (2010) EXPERIMENTAL LUNG RESEARCH. 36(8). p.469-483
abstract
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and extrapulmonary manifestations including systemic inflammation and weight loss. Increased levels of interleukin-6 (IL-6) have been demonstrated in sputum and serum of COPD patients. Therefore, the authors investigated the in vivo role of IL-6 in a murine model of COPD. Wild-type (WT) and IL-6 knockout (KO) mice were exposed subacutely (4 weeks) and chronically (24 weeks) to air or cigarette smoke (CS). Subacute and chronic CS exposure significantly increased pulmonary IL-6 mRNA expression in lung tissue and IL-6 protein levels in bronchoalveolar lavage fluid of WT mice. However, CS-induced accumulation of inflammatory cells at both time points and lymphoid aggregate formation upon chronic CS exposure were independent of IL-6. Chonic CS exposure was associated with a significant failure to gain weight in both WT mice and IL-6 KO mice. Remarkably, air-exposed IL-6 KO mice have lower body weight, serum leptin levels, and adipose tissue mass compared to air-exposed WT mice. In conclusion, IL-6 is of minor importance in CS-induced pulmonary and systemic manifestations in mice, but this study confirms the role for IL-6 as regulator of body weight and body composition
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
interleukin-6, IL-6 GENE, IN-VIVO, C-REACTIVE PROTEIN, INFLAMMATION, MICE, COPD, CELL, EMPHYSEMA, RESISTANCE, systemic inflammation, pulmonary inflammation, NECROSIS-FACTOR-ALPHA
journal title
EXPERIMENTAL LUNG RESEARCH
Exp. Lung Res.
volume
36
issue
8
pages
469 - 483
Web of Science type
Article
Web of Science id
000282885100004
JCR category
RESPIRATORY SYSTEM
JCR impact factor
1.069 (2010)
JCR rank
38/45 (2010)
JCR quartile
4 (2010)
ISSN
0190-2148
DOI
10.3109/01902141003739723
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1184334
handle
http://hdl.handle.net/1854/LU-1184334
date created
2011-03-09 10:04:04
date last changed
2016-12-19 15:45:14
@article{1184334,
  abstract     = {Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and extrapulmonary manifestations including systemic inflammation and weight loss. Increased levels of interleukin-6 (IL-6) have been demonstrated in sputum and serum of COPD patients. Therefore, the authors investigated the in vivo role of IL-6 in a murine model of COPD. Wild-type (WT) and IL-6 knockout (KO) mice were exposed subacutely (4 weeks) and chronically (24 weeks) to air or cigarette smoke (CS). Subacute and chronic CS exposure significantly increased pulmonary IL-6 mRNA expression in lung tissue and IL-6 protein levels in bronchoalveolar lavage fluid of WT mice. However, CS-induced accumulation of inflammatory cells at both time points and lymphoid aggregate formation upon chronic CS exposure were independent of IL-6. Chonic CS exposure was associated with a significant failure to gain weight in both WT mice and IL-6 KO mice. Remarkably, air-exposed IL-6 KO mice have lower body weight, serum leptin levels, and adipose tissue mass compared to air-exposed WT mice. In conclusion, IL-6 is of minor importance in CS-induced pulmonary and systemic manifestations in mice, but this study confirms the role for IL-6 as regulator of body weight and body composition},
  author       = {Pauwels, Nele and Bracke, Ken and Maes, Tania and Pilette, Charles and Joos, Guy and Brusselle, Guy},
  issn         = {0190-2148},
  journal      = {EXPERIMENTAL LUNG RESEARCH},
  keyword      = {interleukin-6,IL-6 GENE,IN-VIVO,C-REACTIVE PROTEIN,INFLAMMATION,MICE,COPD,CELL,EMPHYSEMA,RESISTANCE,systemic inflammation,pulmonary inflammation,NECROSIS-FACTOR-ALPHA},
  language     = {eng},
  number       = {8},
  pages        = {469--483},
  title        = {The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease},
  url          = {http://dx.doi.org/10.3109/01902141003739723},
  volume       = {36},
  year         = {2010},
}

Chicago
Pauwels, Nele, Ken Bracke, Tania Maes, Charles Pilette, Guy Joos, and Guy Brusselle. 2010. “The Role of Interleukin-6 in Pulmonary and Systemic Manifestations in a Murine Model of Chronic Obstructive Pulmonary Disease.” Experimental Lung Research 36 (8): 469–483.
APA
Pauwels, Nele, Bracke, K., Maes, T., Pilette, C., Joos, G., & Brusselle, G. (2010). The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease. EXPERIMENTAL LUNG RESEARCH, 36(8), 469–483.
Vancouver
1.
Pauwels N, Bracke K, Maes T, Pilette C, Joos G, Brusselle G. The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease. EXPERIMENTAL LUNG RESEARCH. 2010;36(8):469–83.
MLA
Pauwels, Nele, Ken Bracke, Tania Maes, et al. “The Role of Interleukin-6 in Pulmonary and Systemic Manifestations in a Murine Model of Chronic Obstructive Pulmonary Disease.” EXPERIMENTAL LUNG RESEARCH 36.8 (2010): 469–483. Print.