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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Carl A Anderson, Gabrielle Goucher, Charlie W Lees, Andre Franke, Mauro D'Amato, Kent D Taylor, James C Lee, Philippe Goyette, Marcin Imielinski and Anna Latiano, et al. (2011) NATURE GENETICS. 43(3). p.246-252
abstract
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MULTIPLE, ENRICHMENT, PROTEIN, CELLS, GENE-EXPRESSION, COMMON VARIANTS, CROHNS-DISEASE, SUSCEPTIBILITY LOCI, GENOME-WIDE ASSOCIATION, INFLAMMATORY-BOWEL-DISEASE
journal title
NATURE GENETICS
Nature Genet.
volume
43
issue
3
pages
246 - 252
Web of Science type
Article
Web of Science id
000287693800016
JCR category
GENETICS & HEREDITY
JCR impact factor
35.532 (2011)
JCR rank
2/155 (2011)
JCR quartile
1 (2011)
ISSN
1061-4036
DOI
10.1038/ng.764
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1182760
handle
http://hdl.handle.net/1854/LU-1182760
date created
2011-03-08 10:05:37
date last changed
2011-04-22 16:36:48
@article{1182760,
  abstract     = {Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P {\textlangle} 5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.},
  author       = {Anderson, Carl A and Goucher, Gabrielle and Lees, Charlie W and Franke, Andre  and D'Amato, Mauro and Taylor, Kent D and Lee, James C and Goyette, Philippe  and Imielinski, Marcin and Latiano, Anna and Lagac{\'e}, Caroline and Scott, Regan and Amininejad, Leila and Bumpstead, Suzannah and Baidoo, Leonard and Baldassano, Robert N and Barclay, Murray and Bayless, Theodore M and Brand, Stephan  and B{\"u}ning, Carsten and Colombel, Jean-Frederic and Denson, Lee A and DE VOS, MARTINE and Dubinski, Maria and Edwards, Cathryn and Ellinghaus, David  and Fehrmann, Rudolf S and Floyd, James A and Florin, Timothy and Franchimont, Denis and Franke, Lude and Georges, Michel and Glas, Juergen and Glazer, Nicole L and Guthery, Stephen L and Haritunians, Talin and Hayward, Nicholas K and Hugot, Jean-Pierre and Jobin, Gilles and Laukens, Debby and Lawrance, Ian and L{\'e}mann, Marc and Levine, Arie and Libioulle, Cecile and Louis, Edouard and McGovern, Dermot P and Milla, Monica and Montgomery, Grant W and Morley, Katherine I and Mowat, Craig and Ng, Aylwin and Newman, William and Ophoff, Roel A and Papi, Laura and Palmieri, Orazio and Peyrin-Biroulet, Laurant and Pan{\'e}s, Julian and Phillips, Anne and Prescott, Natalie J and Proctor, Deborah D and Roberts, Rebecca and Russell, Richard and Rutgeerts, Paul and Sanderson, Jeremy and Sans, Miquel and Schumm, Philip and Seibold, Frank and Sharma, Yashoda and Simms, Lisa A and Seielstad, Mark and Steinhart, A Hillary and Targan, Stephan R and Van den Berg, Leonard H and Vatn, Morten and Verspaget, Hein and Walters, Thomas and Wijmenga, Cisca and Wilson, David C and Westra, Harm-Jan and Xavier, Ramnik J and Zhao, Zhen Z and Ponsioen, Cyriel Y and Andersen, Vibeke and Torkvist, Leif and Gazouli, Maria and Anagou, Nicholas P and Karlsen, Tom H and Kupcinskas, Limas and Sventoraityte, Jurgita and Mansfield, John C and Kugathasan, Subra and Silverberg, Mark S and Halfvarson, Jonas and Rotter, Jerom I and Mathew, Christopher G and Griffiths, Anne M and Gearry, Richard and Ahmad, Tariq and Brant, Steven R and Chamaillard, Mathias  and Satsangi, Jack and Cho, Judy H and Schreiber, Stefan and Daly, Mark J and Barrett, Jeffrey C and Parkes, Miles and Annese, Vito and Hakonarson, Hakon and Radford-Smith, Graham and Duerr, Richard H and Vermeire, Severine and Weersma, Rinse K and Rioux, John D},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keyword      = {MULTIPLE,ENRICHMENT,PROTEIN,CELLS,GENE-EXPRESSION,COMMON VARIANTS,CROHNS-DISEASE,SUSCEPTIBILITY LOCI,GENOME-WIDE ASSOCIATION,INFLAMMATORY-BOWEL-DISEASE},
  language     = {eng},
  number       = {3},
  pages        = {246--252},
  title        = {Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47},
  url          = {http://dx.doi.org/10.1038/ng.764},
  volume       = {43},
  year         = {2011},
}

Chicago
Anderson, Carl A, Gabrielle Goucher, Charlie W Lees, Andre Franke, Mauro D’Amato, Kent D Taylor, James C Lee, et al. 2011. “Meta-analysis Identifies 29 Additional Ulcerative Colitis Risk Loci, Increasing the Number of Confirmed Associations to 47.” Nature Genetics 43 (3): 246–252.
APA
Anderson, C. A., Goucher, G., Lees, C. W., Franke, A., D’Amato, M., Taylor, K. D., Lee, J. C., et al. (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. NATURE GENETICS, 43(3), 246–252.
Vancouver
1.
Anderson CA, Goucher G, Lees CW, Franke A, D’Amato M, Taylor KD, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. NATURE GENETICS. 2011;43(3):246–52.
MLA
Anderson, Carl A, Gabrielle Goucher, Charlie W Lees, et al. “Meta-analysis Identifies 29 Additional Ulcerative Colitis Risk Loci, Increasing the Number of Confirmed Associations to 47.” NATURE GENETICS 43.3 (2011): 246–252. Print.