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Advanced oxidation of pharmaceuticals: chemical analysis and biological assessment of degradation products

Bavo De Witte (UGent) , Herman Van Langenhove (UGent) , Kristof Demeestere (UGent) and Jo Dewulf (UGent)
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Abstract
Pharmaceuticals are often hardly biodegradable and physicochemical technologies are required for their removal from water. Degradation by advanced oxidation processes is intensively studied in last years. However, analytical methodologies to detect AOP-induced pharmaceutical degradation products and to assess their biological effects have not been reviewed until now. The authors aim to fill up this literature gap. The main goal is to bring forward a critical overview of the state-of-the-art of analytical techniques and the information they provide to clearly distinct 5 identification levels that are applicable for micropollutant degradation products in general. Next, literature data dealing with the application of identification tools is systematically summarized. Literature sources were mainly published from 2005 to 2008.
Keywords
biological assessment, advanced oxidation processes, chemical analysis, degradation products, pharmaceuticals, PERSONAL-CARE PRODUCTS, TANDEM MASS-SPECTROMETRY, WASTE-WATER TREATMENT, ENDOCRINE DISRUPTING CHEMICALS, SEWAGE-TREATMENT PLANTS, PHOTOCATALYTIC DEGRADATION, LIQUID-CHROMATOGRAPHY, AQUATIC ENVIRONMENT, ESTROGENIC ACTIVITY, AQUEOUS-MEDIUM

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Citation

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Chicago
De Witte, Bavo, Herman Van Langenhove, Kristof Demeestere, and Jo Dewulf. 2011. “Advanced Oxidation of Pharmaceuticals: Chemical Analysis and Biological Assessment of Degradation Products.” Critical Reviews in Environmental Science and Technology 41 (3): 215–242.
APA
De Witte, B., Van Langenhove, H., Demeestere, K., & Dewulf, J. (2011). Advanced oxidation of pharmaceuticals: chemical analysis and biological assessment of degradation products. CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY, 41(3), 215–242.
Vancouver
1.
De Witte B, Van Langenhove H, Demeestere K, Dewulf J. Advanced oxidation of pharmaceuticals: chemical analysis and biological assessment of degradation products. CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2011;41(3):215–42.
MLA
De Witte, Bavo, Herman Van Langenhove, Kristof Demeestere, et al. “Advanced Oxidation of Pharmaceuticals: Chemical Analysis and Biological Assessment of Degradation Products.” CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY 41.3 (2011): 215–242. Print.
@article{1182034,
  abstract     = {Pharmaceuticals are often hardly biodegradable and physicochemical technologies are required for their removal from water. Degradation by advanced oxidation processes is intensively studied in last years. However, analytical methodologies to detect AOP-induced pharmaceutical degradation products and to assess their biological effects have not been reviewed until now. The authors aim to fill up this literature gap. The main goal is to bring forward a critical overview of the state-of-the-art of analytical techniques and the information they provide to clearly distinct 5 identification levels that are applicable for micropollutant degradation products in general. Next, literature data dealing with the application of identification tools is systematically summarized. Literature sources were mainly published from 2005 to 2008.},
  author       = {De Witte, Bavo and Van Langenhove, Herman and Demeestere, Kristof and Dewulf, Jo},
  issn         = {1064-3389},
  journal      = {CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY},
  keyword      = {biological assessment,advanced oxidation processes,chemical analysis,degradation products,pharmaceuticals,PERSONAL-CARE PRODUCTS,TANDEM MASS-SPECTROMETRY,WASTE-WATER TREATMENT,ENDOCRINE DISRUPTING CHEMICALS,SEWAGE-TREATMENT PLANTS,PHOTOCATALYTIC DEGRADATION,LIQUID-CHROMATOGRAPHY,AQUATIC ENVIRONMENT,ESTROGENIC ACTIVITY,AQUEOUS-MEDIUM},
  language     = {eng},
  number       = {3},
  pages        = {215--242},
  title        = {Advanced oxidation of pharmaceuticals: chemical analysis and biological assessment of degradation products},
  url          = {http://dx.doi.org/10.1080/10643380902728698},
  volume       = {41},
  year         = {2011},
}

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