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Virulence factors of actinobacillus pleuropneumoniae involved in colonization, persistence and induction of lesions in its porcine host

Koen Chiers UGent, Tine De Waele UGent, Frank Pasmans UGent, Richard Ducatelle UGent and Freddy Haesebrouck UGent (2010) VETERINARY RESEARCH. 41(5).
abstract
Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia. The virulence factors of this microorganism involved in colonization and the induction of lung lesions have been thoroughly studied and some have been well characterized. A. pleuropneumoniae binds preferentially to cells of the lower respiratory tract in a process involving different adhesins and probably biofilm formation. Apx toxins and lipopolysaccharides exert pathogenic effects on several host cells, resulting in typical lung lesions. Lysis of host cells is essential for the bacterium to obtain nutrients from the environment and A. pleuropneumoniae has developed several uptake mechanisms for these nutrients. In addition to persistence in lung lesions, colonization of the upper respiratory tract - and of the tonsils in particular - may also be important for long-term persistent asymptomatic infection. Information on virulence factors involved in tonsillar and nasal cavity colonization and persistence is scarce, but it can be speculated that similar features as demonstrated for the lung may play a role.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
HEMOPHILUS-PLEUROPNEUMONIAE, AUTOTRANSPORTER PROTEIN, Actinobacillus pleuropneumoniae, virulence factor, pig, respiratory disease, TRANSFERRIN-BINDING PROTEINS, ALVEOLAR EPITHELIAL-CELLS, RESPIRATORY-TRACT CELLS, OUTER-MEMBRANE PROTEIN, BIOFILM FORMATION, RTX TOXINS APXI, CAPSULAR POLYSACCHARIDE, MYCOPLASMA-HYOPNEUMONIAE
journal title
VETERINARY RESEARCH
Vet. Res.
volume
41
issue
5
article_number
65
pages
16 pages
Web of Science type
Review
Web of Science id
000284063300010
JCR category
VETERINARY SCIENCES
JCR impact factor
3.765 (2010)
JCR rank
1/145 (2010)
JCR quartile
1 (2010)
ISSN
0928-4249
DOI
10.1051/vetres/2010037
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
1182005
handle
http://hdl.handle.net/1854/LU-1182005
date created
2011-03-04 08:33:21
date last changed
2011-05-06 16:22:52
@article{1182005,
  abstract     = {Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia. The virulence factors of this microorganism involved in colonization and the induction of lung lesions have been thoroughly studied and some have been well characterized. A. pleuropneumoniae binds preferentially to cells of the lower respiratory tract in a process involving different adhesins and probably biofilm formation. Apx toxins and lipopolysaccharides exert pathogenic effects on several host cells, resulting in typical lung lesions. Lysis of host cells is essential for the bacterium to obtain nutrients from the environment and A. pleuropneumoniae has developed several uptake mechanisms for these nutrients. In addition to persistence in lung lesions, colonization of the upper respiratory tract - and of the tonsils in particular - may also be important for long-term persistent asymptomatic infection. Information on virulence factors involved in tonsillar and nasal cavity colonization and persistence is scarce, but it can be speculated that similar features as demonstrated for the lung may play a role.},
  articleno    = {65},
  author       = {Chiers, Koen and De Waele, Tine and Pasmans, Frank and Ducatelle, Richard and Haesebrouck, Freddy},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  keyword      = {HEMOPHILUS-PLEUROPNEUMONIAE,AUTOTRANSPORTER PROTEIN,Actinobacillus pleuropneumoniae,virulence factor,pig,respiratory disease,TRANSFERRIN-BINDING PROTEINS,ALVEOLAR EPITHELIAL-CELLS,RESPIRATORY-TRACT CELLS,OUTER-MEMBRANE PROTEIN,BIOFILM FORMATION,RTX TOXINS APXI,CAPSULAR POLYSACCHARIDE,MYCOPLASMA-HYOPNEUMONIAE},
  language     = {eng},
  number       = {5},
  pages        = {16},
  title        = {Virulence factors of actinobacillus pleuropneumoniae involved in colonization, persistence and induction of lesions in its porcine host},
  url          = {http://dx.doi.org/10.1051/vetres/2010037},
  volume       = {41},
  year         = {2010},
}

Chicago
Chiers, Koen, Tine De Waele, Frank Pasmans, Richard Ducatelle, and Freddy Haesebrouck. 2010. “Virulence Factors of Actinobacillus Pleuropneumoniae Involved in Colonization, Persistence and Induction of Lesions in Its Porcine Host.” Veterinary Research 41 (5).
APA
Chiers, K., De Waele, T., Pasmans, F., Ducatelle, R., & Haesebrouck, F. (2010). Virulence factors of actinobacillus pleuropneumoniae involved in colonization, persistence and induction of lesions in its porcine host. VETERINARY RESEARCH, 41(5).
Vancouver
1.
Chiers K, De Waele T, Pasmans F, Ducatelle R, Haesebrouck F. Virulence factors of actinobacillus pleuropneumoniae involved in colonization, persistence and induction of lesions in its porcine host. VETERINARY RESEARCH. 2010;41(5).
MLA
Chiers, Koen, Tine De Waele, Frank Pasmans, et al. “Virulence Factors of Actinobacillus Pleuropneumoniae Involved in Colonization, Persistence and Induction of Lesions in Its Porcine Host.” VETERINARY RESEARCH 41.5 (2010): n. pag. Print.