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Haptoglobin polymorphism and infection

Ishmael Kasvosve, Marijn Speeckaert UGent, Reinhart Speeckaert, Gwinyai Masukume and Joris Delanghe UGent (2010) ADVANCES IN CLINICAL CHEMISTRY. In Advances in Clinical Chemistry 50. p.23-46
abstract
The haptoglobin gene is highly polymorphic in humans with strong evidence of functionally distinct biochemical phenotypes. In all human populations, three major haptoglobin phenotypes Hp 1-1, Hp 2-1, and Hp 2-2 are present, but additional phenotypes have been identified. Haptoglobin polymorphism has important biological and clinical significance. In this review, we examine the putative role of haptoglobin polymorphism in parasitic, bacterial, and viral infections. Despite many striking effects of haptoglobin polymorphism in infectious conditions, the effects of haptoglobin genetic variation upon infections are not always predictable due to the multifunctional character of the plasma protein (e.g., antibody-like properties, immunomodulation, iron metabolism). More studies on the interplay of haptoglobin polymorphism, vaccination, and susceptibility or resistance to common infections seem warranted.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
HOST IRON STATUS, NONTYPABLE HAEMOPHILUS-INFLUENZAE, HUMAN LYMPHOCYTES-B, CHRONIC HEPATITIS-C, BARR VIRUS RECEPTOR, CYSTEINE-RICH FAMILY, OUTER-MEMBRANE PROTEIN, PLASMODIUM-FALCIPARUM MALARIA, SCAVENGER RECEPTOR CD163, POLYMERASE-CHAIN-REACTION
journal title
ADVANCES IN CLINICAL CHEMISTRY
Advan. Clin. Chem.
series title
Advances in Clinical Chemistry
volume
50
pages
23 - 46
Web of Science type
Review
Web of Science id
000278107100002
JCR category
MEDICAL LABORATORY TECHNOLOGY
JCR impact factor
3.263 (2010)
JCR rank
3/30 (2010)
JCR quartile
1 (2010)
ISSN
0065-2423
DOI
10.1016/S0065-2423(10)50002-7
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1181450
handle
http://hdl.handle.net/1854/LU-1181450
date created
2011-03-03 11:08:35
date last changed
2016-12-19 15:45:14
@article{1181450,
  abstract     = {The haptoglobin gene is highly polymorphic in humans with strong evidence of functionally distinct biochemical phenotypes. In all human populations, three major haptoglobin phenotypes Hp 1-1, Hp 2-1, and Hp 2-2 are present, but additional phenotypes have been identified. Haptoglobin polymorphism has important biological and clinical significance. In this review, we examine the putative role of haptoglobin polymorphism in parasitic, bacterial, and viral infections. Despite many striking effects of haptoglobin polymorphism in infectious conditions, the effects of haptoglobin genetic variation upon infections are not always predictable due to the multifunctional character of the plasma protein (e.g., antibody-like properties, immunomodulation, iron metabolism). More studies on the interplay of haptoglobin polymorphism, vaccination, and susceptibility or resistance to common infections seem warranted.},
  author       = {Kasvosve, Ishmael and Speeckaert, Marijn and Speeckaert, Reinhart and Masukume, Gwinyai and Delanghe, Joris},
  issn         = {0065-2423},
  journal      = {ADVANCES IN CLINICAL CHEMISTRY},
  keyword      = {HOST IRON STATUS,NONTYPABLE HAEMOPHILUS-INFLUENZAE,HUMAN LYMPHOCYTES-B,CHRONIC HEPATITIS-C,BARR VIRUS RECEPTOR,CYSTEINE-RICH FAMILY,OUTER-MEMBRANE PROTEIN,PLASMODIUM-FALCIPARUM MALARIA,SCAVENGER RECEPTOR CD163,POLYMERASE-CHAIN-REACTION},
  language     = {eng},
  pages        = {23--46},
  title        = {Haptoglobin polymorphism and infection},
  url          = {http://dx.doi.org/10.1016/S0065-2423(10)50002-7},
  volume       = {50},
  year         = {2010},
}

Chicago
Kasvosve, Ishmael, Marijn Speeckaert, Reinhart Speeckaert, Gwinyai Masukume, and Joris Delanghe. 2010. “Haptoglobin Polymorphism and Infection.” Advances in Clinical Chemistry 50: 23–46.
APA
Kasvosve, I., Speeckaert, M., Speeckaert, R., Masukume, G., & Delanghe, J. (2010). Haptoglobin polymorphism and infection. ADVANCES IN CLINICAL CHEMISTRY, 50, 23–46.
Vancouver
1.
Kasvosve I, Speeckaert M, Speeckaert R, Masukume G, Delanghe J. Haptoglobin polymorphism and infection. ADVANCES IN CLINICAL CHEMISTRY. 2010;50:23–46.
MLA
Kasvosve, Ishmael, Marijn Speeckaert, Reinhart Speeckaert, et al. “Haptoglobin Polymorphism and Infection.” ADVANCES IN CLINICAL CHEMISTRY 50 (2010): 23–46. Print.