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The haptoglobin gene is highly polymorphic in humans with strong evidence of functionally distinct biochemical phenotypes. In all human populations, three major haptoglobin phenotypes Hp 1-1, Hp 2-1, and Hp 2-2 are present, but additional phenotypes have been identified. Haptoglobin polymorphism has important biological and clinical significance. In this review, we examine the putative role of haptoglobin polymorphism in parasitic, bacterial, and viral infections. Despite many striking effects of haptoglobin polymorphism in infectious conditions, the effects of haptoglobin genetic variation upon infections are not always predictable due to the multifunctional character of the plasma protein (e.g., antibody-like properties, immunomodulation, iron metabolism). More studies on the interplay of haptoglobin polymorphism, vaccination, and susceptibility or resistance to common infections seem warranted.
Keywords
HOST IRON STATUS, NONTYPABLE HAEMOPHILUS-INFLUENZAE, HUMAN LYMPHOCYTES-B, CHRONIC HEPATITIS-C, BARR VIRUS RECEPTOR, CYSTEINE-RICH FAMILY, OUTER-MEMBRANE PROTEIN, PLASMODIUM-FALCIPARUM MALARIA, SCAVENGER RECEPTOR CD163, POLYMERASE-CHAIN-REACTION

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Chicago
Kasvosve, Ishmael, Marijn Speeckaert, Reinhart Speeckaert, Gwinyai Masukume, and Joris Delanghe. 2010. “Haptoglobin Polymorphism and Infection.” Advances in Clinical Chemistry 50: 23–46.
APA
Kasvosve, I., Speeckaert, M., Speeckaert, R., Masukume, G., & Delanghe, J. (2010). Haptoglobin polymorphism and infection. ADVANCES IN CLINICAL CHEMISTRY, 50, 23–46.
Vancouver
1.
Kasvosve I, Speeckaert M, Speeckaert R, Masukume G, Delanghe J. Haptoglobin polymorphism and infection. ADVANCES IN CLINICAL CHEMISTRY. 2010;50:23–46.
MLA
Kasvosve, Ishmael, Marijn Speeckaert, Reinhart Speeckaert, et al. “Haptoglobin Polymorphism and Infection.” ADVANCES IN CLINICAL CHEMISTRY 50 (2010): 23–46. Print.
@article{1181450,
  abstract     = {The haptoglobin gene is highly polymorphic in humans with strong evidence of functionally distinct biochemical phenotypes. In all human populations, three major haptoglobin phenotypes Hp 1-1, Hp 2-1, and Hp 2-2 are present, but additional phenotypes have been identified. Haptoglobin polymorphism has important biological and clinical significance. In this review, we examine the putative role of haptoglobin polymorphism in parasitic, bacterial, and viral infections. Despite many striking effects of haptoglobin polymorphism in infectious conditions, the effects of haptoglobin genetic variation upon infections are not always predictable due to the multifunctional character of the plasma protein (e.g., antibody-like properties, immunomodulation, iron metabolism). More studies on the interplay of haptoglobin polymorphism, vaccination, and susceptibility or resistance to common infections seem warranted.},
  author       = {Kasvosve, Ishmael and Speeckaert, Marijn and Speeckaert, Reinhart and Masukume, Gwinyai and Delanghe, Joris},
  issn         = {0065-2423},
  journal      = {ADVANCES IN CLINICAL CHEMISTRY},
  keyword      = {HOST IRON STATUS,NONTYPABLE HAEMOPHILUS-INFLUENZAE,HUMAN LYMPHOCYTES-B,CHRONIC HEPATITIS-C,BARR VIRUS RECEPTOR,CYSTEINE-RICH FAMILY,OUTER-MEMBRANE PROTEIN,PLASMODIUM-FALCIPARUM MALARIA,SCAVENGER RECEPTOR CD163,POLYMERASE-CHAIN-REACTION},
  language     = {eng},
  pages        = {23--46},
  title        = {Haptoglobin polymorphism and infection},
  url          = {http://dx.doi.org/10.1016/S0065-2423(10)50002-7},
  volume       = {50},
  year         = {2010},
}

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