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Haptoglobin phenotype correlates with the extent of cerebral deep white matter lesions in hypertensive patients

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Abstract
Cerebral white matter lesions (WMLs), due to small vessel disease, can be regarded as an early "silent" sign of hypertensive cerebral end-organ damage. As haptoglobin (Hp) phenotype has earlier been associated with symptomatic vascular disease, we now examined the relationship between Hp phenotype and asymptomatic cerebral small vessel disease, manifested by deep and periventricular WMLs, in hypertensive patients. We determined Hp phenotype using starch gel electrophoresis in 152 hypertensive patients without symptomatic vascular disease. We found 26 (17.1%) Hp1-1, 89 (58.6%) Hp2-1 and 37 (24.3%) Hp2-2. Volumes of deep and periventricular WMLs were quantitatively measured on brain MR images. Patients were ranked in 5 categories according to ascending WMLs volumes. Compared to Hp2-2, Hp1-1 was associated with larger deep WMLs volumes when adjusted for age, gender, brain volume, 24-hour mean arterial pressure, duration of hypertension and previous antihypertensive treatment (ordinal regression analysis, OR 2.77, 95%CI 1.08-7.11, p=0.034). No association was found between Hp phenotype and periventricular WMLs. Hp1-1 phenotype correlates with the extent of hypertensive deep white matter damage. One of the possibilities is that this is related to lower regenerating power against endothelial injury in Hp1-1 individuals.
Keywords
haptoglobin phenotype, Cerebrovascular disease, MEMORY, HYPERINTENSITIES, POPULATION, RISK, LEUKOARAIOSIS, GENOTYPE, POLYMORPHISM, BLOOD-PRESSURE, LACUNAR STROKE, hypertension, SMALL-VESSEL DISEASE, white matter lesions, small vessel disease

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Chicago
Staals, Julie, Leon HG Henskens, Joris Delanghe, Robert J van Oostenbrugge, Alfons G Kessels, Abraham A Kroon, Peter W de Leeuw, and Jan Lodder. 2010. “Haptoglobin Phenotype Correlates with the Extent of Cerebral Deep White Matter Lesions in Hypertensive Patients.” Current Neurovascular Research 7 (1): 1–5.
APA
Staals, J., Henskens, L. H., Delanghe, J., van Oostenbrugge, R. J., Kessels, A. G., Kroon, A. A., de Leeuw, P. W., et al. (2010). Haptoglobin phenotype correlates with the extent of cerebral deep white matter lesions in hypertensive patients. CURRENT NEUROVASCULAR RESEARCH, 7(1), 1–5.
Vancouver
1.
Staals J, Henskens LH, Delanghe J, van Oostenbrugge RJ, Kessels AG, Kroon AA, et al. Haptoglobin phenotype correlates with the extent of cerebral deep white matter lesions in hypertensive patients. CURRENT NEUROVASCULAR RESEARCH. 2010;7(1):1–5.
MLA
Staals, Julie, Leon HG Henskens, Joris Delanghe, et al. “Haptoglobin Phenotype Correlates with the Extent of Cerebral Deep White Matter Lesions in Hypertensive Patients.” CURRENT NEUROVASCULAR RESEARCH 7.1 (2010): 1–5. Print.
@article{1181428,
  abstract     = {Cerebral white matter lesions (WMLs), due to small vessel disease, can be regarded as an early {\textacutedbl}silent{\textacutedbl} sign of hypertensive cerebral end-organ damage. As haptoglobin (Hp) phenotype has earlier been associated with symptomatic vascular disease, we now examined the relationship between Hp phenotype and asymptomatic cerebral small vessel disease, manifested by deep and periventricular WMLs, in hypertensive patients. We determined Hp phenotype using starch gel electrophoresis in 152 hypertensive patients without symptomatic vascular disease. We found 26 (17.1\%) Hp1-1, 89 (58.6\%) Hp2-1 and 37 (24.3\%) Hp2-2. Volumes of deep and periventricular WMLs were quantitatively measured on brain MR images. Patients were ranked in 5 categories according to ascending WMLs volumes. Compared to Hp2-2, Hp1-1 was associated with larger deep WMLs volumes when adjusted for age, gender, brain volume, 24-hour mean arterial pressure, duration of hypertension and previous antihypertensive treatment (ordinal regression analysis, OR 2.77, 95\%CI 1.08-7.11, p=0.034). No association was found between Hp phenotype and periventricular WMLs. Hp1-1 phenotype correlates with the extent of hypertensive deep white matter damage. One of the possibilities is that this is related to lower regenerating power against endothelial injury in Hp1-1 individuals.},
  author       = {Staals, Julie and Henskens, Leon HG and Delanghe, Joris and van Oostenbrugge, Robert J and Kessels, Alfons G and Kroon, Abraham A and de Leeuw, Peter W and Lodder, Jan},
  issn         = {1567-2026},
  journal      = {CURRENT NEUROVASCULAR RESEARCH},
  keyword      = {haptoglobin phenotype,Cerebrovascular disease,MEMORY,HYPERINTENSITIES,POPULATION,RISK,LEUKOARAIOSIS,GENOTYPE,POLYMORPHISM,BLOOD-PRESSURE,LACUNAR STROKE,hypertension,SMALL-VESSEL DISEASE,white matter lesions,small vessel disease},
  language     = {eng},
  number       = {1},
  pages        = {1--5},
  title        = {Haptoglobin phenotype correlates with the extent of cerebral deep white matter lesions in hypertensive patients},
  volume       = {7},
  year         = {2010},
}

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