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Oral β-1,3/1,6-glucans as immunmodulators in pigs

Edith Stuyven UGent, Sven Arnouts UGent, Bruno Goddeeris UGent and Eric Cox UGent (2010) 14th international conference on production diseases in farm animals (ICPD), Abstracts.
abstract
The cell wall glucans of yeasts and fungi consist of a linear backbone of -1,3-linked glucosylunits with -1,6-linked side chains (1). Although a lot is already known about the mechanism of action of -1,3/1,6-glucans on the innate immune system (2), there is still a lot to be learned about their effects on the adaptive immune system in mammals. We aimed to determine if oral supplementation could modulate a systemic immune response. The latter was examined in pigs using a model antigen. In three experiments using newly weaned pigs, Macrogard, a β-1,3/1,6-glucan from Saccharomyces cerevisiae, was administered in the feed during three different time periods (one, two and three weeks) and the adjuvant effect of this β-glucan was determined on a systemic immunisation with thyroglobulin. A first immunisation occurred during β-glucan supplementation, while the second one occurred after ceasing the administration. Macrogard exerted significantly higher thyroglobulin-specific primary immunoglobulin (Ig) M and secondary IgA antibody responses in serum. However, Macrogard suppressed the thyroglobulin-specific proliferation of peripheral blood mononuclear cells. A higher dose of Macrogard significantly increased thyroglobulin-specific IgM but not IgA responses, and the animals itself showed hyperaemia. Suppression of the T-lymphocyte proliferation might account for the absence of the switch from IgM to IgA. Weight gain and feed conversion were also determined, without significant differences between groups. In conclusion, oral β-glucans are able to modulate the humoral as well as the cellular immunity against a systemically administered antigen.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
Oral β-1, 6-glucans as immunmodulators in pigs, 3/1
in
14th international conference on production diseases in farm animals (ICPD), Abstracts
conference name
14th International Conference on Production Diseases in Farm Animals (ICPD)
conference location
Ghent, Belgium
conference start
2010-06-16
conference end
2010-06-16
language
English
UGent publication?
yes
classification
C3
copyright statement
I have retained and own the full copyright for this publication
id
1181350
handle
http://hdl.handle.net/1854/LU-1181350
date created
2011-03-03 10:23:07
date last changed
2011-05-03 14:10:57
@inproceedings{1181350,
  abstract     = {The cell wall glucans of yeasts and fungi consist of a linear backbone of \unmatched{f062}-1,3-linked glucosylunits with \unmatched{f062}-1,6-linked side chains (1). Although a lot is already known about the mechanism of action of \unmatched{f062}-1,3/1,6-glucans on the innate immune system (2), there is still a lot to be learned about their effects on the adaptive immune system in mammals. We aimed to determine if oral supplementation could modulate a systemic immune response. The latter was examined in pigs using a model antigen. In three experiments using newly weaned pigs, Macrogard, a \ensuremath{\beta}-1,3/1,6-glucan from Saccharomyces cerevisiae, was administered in the feed during three different time periods (one, two and three weeks) and the adjuvant effect of this \ensuremath{\beta}-glucan was determined on a systemic immunisation with thyroglobulin. A first immunisation occurred during \ensuremath{\beta}-glucan supplementation, while the second one occurred after ceasing the administration. Macrogard exerted significantly higher thyroglobulin-specific primary immunoglobulin (Ig) M and secondary IgA antibody responses in serum. However, Macrogard suppressed the thyroglobulin-specific proliferation of peripheral blood mononuclear cells. A higher dose of Macrogard significantly increased thyroglobulin-specific IgM but not IgA responses, and the animals itself showed hyperaemia. Suppression of the T-lymphocyte proliferation might account for the absence of the switch from IgM to IgA. Weight gain and feed conversion were also determined, without significant differences between groups. In conclusion, oral \ensuremath{\beta}-glucans are able to modulate the humoral as well as the cellular immunity against a systemically administered antigen.},
  author       = {Stuyven, Edith and Arnouts, Sven and Goddeeris, Bruno and Cox, Eric},
  booktitle    = {14th international conference on production diseases in farm animals (ICPD), Abstracts},
  keyword      = {Oral \ensuremath{\beta}-1,6-glucans as immunmodulators in pigs,3/1},
  language     = {eng},
  location     = {Ghent, Belgium},
  title        = {Oral \ensuremath{\beta}-1,3/1,6-glucans as immunmodulators in pigs},
  year         = {2010},
}

Chicago
Stuyven, Edith, Sven Arnouts, Bruno Goddeeris, and Eric Cox. 2010. “Oral Β-1,3/1,6-glucans as Immunmodulators in Pigs.” In 14th International Conference on Production Diseases in Farm Animals (ICPD), Abstracts.
APA
Stuyven, E., Arnouts, S., Goddeeris, B., & Cox, E. (2010). Oral β-1,3/1,6-glucans as immunmodulators in pigs. 14th international conference on production diseases in farm animals (ICPD), Abstracts. Presented at the 14th International Conference on Production Diseases in Farm Animals (ICPD).
Vancouver
1.
Stuyven E, Arnouts S, Goddeeris B, Cox E. Oral β-1,3/1,6-glucans as immunmodulators in pigs. 14th international conference on production diseases in farm animals (ICPD), Abstracts. 2010.
MLA
Stuyven, Edith, Sven Arnouts, Bruno Goddeeris, et al. “Oral Β-1,3/1,6-glucans as Immunmodulators in Pigs.” 14th International Conference on Production Diseases in Farm Animals (ICPD), Abstracts. 2010. Print.