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Genome sequence of Helicobacter suis supports its role in gastric pathology

Miet Vermoote (UGent) , Tom Vandekerckhove (UGent) , Bram Flahou (UGent) , Frank Pasmans (UGent) , Annemieke Smet (UGent) , Dominic De Groote (UGent) , Wim Van Criekinge (UGent) , Richard Ducatelle (UGent) and Freddy Haesebrouck (UGent)
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Bioinformatics: from nucleotids to networks (N2N)
Abstract
Helicobacter (H.) suis has been associated with chronic gastritis and ulcers of the pars oesophagea in pigs, and with gastritis, peptic ulcer disease and gastric mucosa-associated lymphoid tissue lymphoma in humans. In order to obtain better insight into the genes involved in pathogenicity and in the specific adaptation to the gastric environment of H. suis, a genome analysis was performed of two H. suis strains isolated from the gastric mucosa of swine. Homologs of the vast majority of genes shown to be important for gastric colonization of the human pathogen H. pylori were detected in the H. suis genome. H. suis encodes several putative outer membrane proteins, of which two similar to the H. pylori adhesins HpaA and HorB. H. suis harbours an almost complete comB type IV secretion system and members of the type IV secretion system 3, but lacks most of the genes present in the cag pathogenicity island of H. pylori. Homologs of genes encoding the H. pylori neutrophil-activating protein and g-glutamyl transpeptidase were identified in H. suis. H. suis also possesses several other presumptive virulence-associated genes, including homologs for mviN, the H. pylori flavodoxin gene, and a homolog of the H. pylori vacuolating cytotoxin A gene. It was concluded that although genes coding for some important virulence factors in H. pylori, such as the cytotoxin-associated protein (CagA), are not detected in the H. suis genome, homologs of other genes associated with colonization and virulence of H. pylori and other bacteria are present.
Keywords
Helicobacter suis, genome sequence, virulence-associated gene, gastric pathology, GAMMA-GLUTAMYL-TRANSPEPTIDASE, IV SECRETION, TRANSFORMATION COMPETENCE, ALIPHATIC AMIDASE, ESCHERICHIA-COLI, SIGNAL PEPTIDES, MESSENGER-RNA, PYLORI, PROTEIN, GENES

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Chicago
Vermoote, Miet, Tom Vandekerckhove, Bram Flahou, Frank Pasmans, Annemieke Smet, Dominic De Groote, Wim Van Criekinge, Richard Ducatelle, and Freddy Haesebrouck. 2011. “Genome Sequence of Helicobacter Suis Supports Its Role in Gastric Pathology.” Veterinary Research 42.
APA
Vermoote, M., Vandekerckhove, T., Flahou, B., Pasmans, F., Smet, A., De Groote, D., Van Criekinge, W., et al. (2011). Genome sequence of Helicobacter suis supports its role in gastric pathology. VETERINARY RESEARCH, 42.
Vancouver
1.
Vermoote M, Vandekerckhove T, Flahou B, Pasmans F, Smet A, De Groote D, et al. Genome sequence of Helicobacter suis supports its role in gastric pathology. VETERINARY RESEARCH. 2011;42.
MLA
Vermoote, Miet, Tom Vandekerckhove, Bram Flahou, et al. “Genome Sequence of Helicobacter Suis Supports Its Role in Gastric Pathology.” VETERINARY RESEARCH 42 (2011): n. pag. Print.
@article{1180168,
  abstract     = {Helicobacter (H.) suis has been associated with chronic gastritis and ulcers of the pars oesophagea in pigs, and with gastritis, peptic ulcer disease and gastric mucosa-associated lymphoid tissue lymphoma in humans. In order to obtain better insight into the genes involved in pathogenicity and in the specific adaptation to the gastric environment of H. suis, a genome analysis was performed of two H. suis strains isolated from the gastric mucosa of swine. Homologs of the vast majority of genes shown to be important for gastric colonization of the human pathogen H. pylori were detected in the H. suis genome. H. suis encodes several putative outer membrane proteins, of which two similar to the H. pylori adhesins HpaA and HorB. H. suis harbours an almost complete comB type IV secretion system and members of the type IV secretion system 3, but lacks most of the genes present in the cag pathogenicity island of H. pylori. Homologs of genes encoding the H. pylori neutrophil-activating protein and g-glutamyl transpeptidase were identified in H. suis. H. suis also possesses several other presumptive virulence-associated genes, including homologs for mviN, the H. pylori flavodoxin gene, and a homolog of the H. pylori vacuolating cytotoxin A gene. It was concluded that although genes coding for some important virulence factors in H. pylori, such as the cytotoxin-associated protein (CagA), are not detected in the H. suis genome, homologs of other genes associated with colonization and virulence of H. pylori and other bacteria are present.},
  articleno    = {51},
  author       = {Vermoote, Miet and Vandekerckhove, Tom and Flahou, Bram and Pasmans, Frank and Smet, Annemieke and De Groote, Dominic and Van Criekinge, Wim and Ducatelle, Richard and Haesebrouck, Freddy},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  keywords     = {Helicobacter suis,genome sequence,virulence-associated gene,gastric pathology,GAMMA-GLUTAMYL-TRANSPEPTIDASE,IV SECRETION,TRANSFORMATION COMPETENCE,ALIPHATIC AMIDASE,ESCHERICHIA-COLI,SIGNAL PEPTIDES,MESSENGER-RNA,PYLORI,PROTEIN,GENES},
  language     = {eng},
  pages        = {9},
  title        = {Genome sequence of Helicobacter suis supports its role in gastric pathology},
  url          = {http://dx.doi.org/10.1186/1297-9716-42-51},
  volume       = {42},
  year         = {2011},
}

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