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Genome sequence of Helicobacter suis supports its role in gastric pathology

Miet Vermoote UGent, Tom Vandekerckhove UGent, Bram Flahou UGent, Frank Pasmans UGent, Annemieke Smet UGent, Dominic De Groote UGent, Wim Van Criekinge UGent, Richard Ducatelle UGent and Freddy Haesebrouck UGent (2011) VETERINARY RESEARCH. 42.
abstract
Helicobacter (H.) suis has been associated with chronic gastritis and ulcers of the pars oesophagea in pigs, and with gastritis, peptic ulcer disease and gastric mucosa-associated lymphoid tissue lymphoma in humans. In order to obtain better insight into the genes involved in pathogenicity and in the specific adaptation to the gastric environment of H. suis, a genome analysis was performed of two H. suis strains isolated from the gastric mucosa of swine. Homologs of the vast majority of genes shown to be important for gastric colonization of the human pathogen H. pylori were detected in the H. suis genome. H. suis encodes several putative outer membrane proteins, of which two similar to the H. pylori adhesins HpaA and HorB. H. suis harbours an almost complete comB type IV secretion system and members of the type IV secretion system 3, but lacks most of the genes present in the cag pathogenicity island of H. pylori. Homologs of genes encoding the H. pylori neutrophil-activating protein and g-glutamyl transpeptidase were identified in H. suis. H. suis also possesses several other presumptive virulence-associated genes, including homologs for mviN, the H. pylori flavodoxin gene, and a homolog of the H. pylori vacuolating cytotoxin A gene. It was concluded that although genes coding for some important virulence factors in H. pylori, such as the cytotoxin-associated protein (CagA), are not detected in the H. suis genome, homologs of other genes associated with colonization and virulence of H. pylori and other bacteria are present.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Helicobacter suis, genome sequence, virulence-associated gene, gastric pathology, GAMMA-GLUTAMYL-TRANSPEPTIDASE, IV SECRETION, TRANSFORMATION COMPETENCE, ALIPHATIC AMIDASE, ESCHERICHIA-COLI, SIGNAL PEPTIDES, MESSENGER-RNA, PYLORI, PROTEIN, GENES
journal title
VETERINARY RESEARCH
Vet. Res.
volume
42
article_number
51
pages
9 pages
Web of Science type
Article
Web of Science id
000290662600004
JCR category
VETERINARY SCIENCES
JCR impact factor
4.06 (2011)
JCR rank
1/141 (2011)
JCR quartile
1 (2011)
ISSN
0928-4249
DOI
10.1186/1297-9716-42-51
project
Bioinformatics: from nucleotids to networks (N2N)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
1180168
handle
http://hdl.handle.net/1854/LU-1180168
date created
2011-03-02 09:31:50
date last changed
2013-02-27 09:11:24
@article{1180168,
  abstract     = {Helicobacter (H.) suis has been associated with chronic gastritis and ulcers of the pars oesophagea in pigs, and with gastritis, peptic ulcer disease and gastric mucosa-associated lymphoid tissue lymphoma in humans. In order to obtain better insight into the genes involved in pathogenicity and in the specific adaptation to the gastric environment of H. suis, a genome analysis was performed of two H. suis strains isolated from the gastric mucosa of swine. Homologs of the vast majority of genes shown to be important for gastric colonization of the human pathogen H. pylori were detected in the H. suis genome. H. suis encodes several putative outer membrane proteins, of which two similar to the H. pylori adhesins HpaA and HorB. H. suis harbours an almost complete comB type IV secretion system and members of the type IV secretion system 3, but lacks most of the genes present in the cag pathogenicity island of H. pylori. Homologs of genes encoding the H. pylori neutrophil-activating protein and g-glutamyl transpeptidase were identified in H. suis. H. suis also possesses several other presumptive virulence-associated genes, including homologs for mviN, the H. pylori flavodoxin gene, and a homolog of the H. pylori vacuolating cytotoxin A gene. It was concluded that although genes coding for some important virulence factors in H. pylori, such as the cytotoxin-associated protein (CagA), are not detected in the H. suis genome, homologs of other genes associated with colonization and virulence of H. pylori and other bacteria are present.},
  articleno    = {51},
  author       = {Vermoote, Miet and Vandekerckhove, Tom and Flahou, Bram and Pasmans, Frank and Smet, Annemieke and De Groote, Dominic and Van Criekinge, Wim and Ducatelle, Richard and Haesebrouck, Freddy},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  keyword      = {Helicobacter suis,genome sequence,virulence-associated gene,gastric pathology,GAMMA-GLUTAMYL-TRANSPEPTIDASE,IV SECRETION,TRANSFORMATION COMPETENCE,ALIPHATIC AMIDASE,ESCHERICHIA-COLI,SIGNAL PEPTIDES,MESSENGER-RNA,PYLORI,PROTEIN,GENES},
  language     = {eng},
  pages        = {9},
  title        = {Genome sequence of Helicobacter suis supports its role in gastric pathology},
  url          = {http://dx.doi.org/10.1186/1297-9716-42-51},
  volume       = {42},
  year         = {2011},
}

Chicago
Vermoote, Miet, Tom Vandekerckhove, Bram Flahou, Frank Pasmans, Annemieke Smet, Dominic De Groote, Wim Van Criekinge, Richard Ducatelle, and Freddy Haesebrouck. 2011. “Genome Sequence of Helicobacter Suis Supports Its Role in Gastric Pathology.” Veterinary Research 42.
APA
Vermoote, M., Vandekerckhove, T., Flahou, B., Pasmans, F., Smet, A., De Groote, D., Van Criekinge, W., et al. (2011). Genome sequence of Helicobacter suis supports its role in gastric pathology. VETERINARY RESEARCH, 42.
Vancouver
1.
Vermoote M, Vandekerckhove T, Flahou B, Pasmans F, Smet A, De Groote D, et al. Genome sequence of Helicobacter suis supports its role in gastric pathology. VETERINARY RESEARCH. 2011;42.
MLA
Vermoote, Miet, Tom Vandekerckhove, Bram Flahou, et al. “Genome Sequence of Helicobacter Suis Supports Its Role in Gastric Pathology.” VETERINARY RESEARCH 42 (2011): n. pag. Print.