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Prospective evaluation of the change of predialysis protein-bound uremic solute concentration with postdilution online hemodiafiltration

Natalie Meert UGent, MARIA WATERLOOS UGent, MARIA VAN LANDSCHOOT UGent, Annemieke Dhondt UGent, Ingid Ledebo, Griet Glorieux UGent, Jan Goeman, Johan Van der Eycken and Raymond Vanholder UGent (2010) ARTIFICIAL ORGANS. 34(7). p.580-585
abstract
Although protein-bound uremic compounds have been related to outcome in observational studies, few current dialysis strategies provide more removal of those compounds than standard hemodialysis. We evaluated the evolution of protein-bound uremic solutes after a switch from high-flux hemodialysis to postdilution hemodiafiltration (n = 13). We compared predialysis solute concentration at 4, 5, and 9 weeks versus baseline for several protein-bound compounds and water-soluble solutes, as well as for beta(2)-microglobulin. After 9 weeks of postdilution hemodiafiltration, a significant decrease versus baseline could be detected for total concentration of protein-bound solutes: p-cresylsulfate (3.98 +/- 1.51-3.17 +/- 1.77 mg/dL, -20%, P < 0.01) and 3-carboxyl-4-methyl-5-propyl-2-furanpropionic acid (0.72 +/- 0.52-0.64 +/- 0.46 mg/dL, -11%, P < 0.01). For the other protein-bound solutes, hippuric acid, indoleacetic acid, and indoxylsulfate, no change in total concentration could be detected. The concentration of the middle molecule, beta(2)-microglobulin, decreased as well after 9 weeks of postdilution hemodiafiltration (24.7 +/- 9.3-18.1 +/- 6.7 mg/L, -27%, P < 0.01). For water-soluble compounds, no significant change of concentration was found. Postdilution hemodiafiltration in comparison to high-flux hemodialysis provided significant reduction of predialysis concentration of protein-bound compounds, especially those with the highest protein binding, and of beta(2)-microglobulin, by -11 to -27% in 9 weeks.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INDOXYL SULFATE, HEMODIALYSIS-PATIENTS, FREE P-CRESOL, Protein binding, Uremic toxins, Postdilution, Hemodialysis, Hemodiafiltration, FLUX HEMODIALYSIS, REMOVAL, TOXINS, DISEASE
journal title
ARTIFICIAL ORGANS
Artif. Organs
volume
34
issue
7
pages
580 - 585
Web of Science type
Article
Web of Science id
000279532900011
JCR category
ENGINEERING, BIOMEDICAL
JCR impact factor
1.719 (2010)
JCR rank
33/68 (2010)
JCR quartile
2 (2010)
ISSN
0160-564X
DOI
10.1111/j.1525-1594.2010.01005.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1176767
handle
http://hdl.handle.net/1854/LU-1176767
date created
2011-02-28 16:30:26
date last changed
2011-03-21 13:14:18
@article{1176767,
  abstract     = {Although protein-bound uremic compounds have been related to outcome in observational studies, few current dialysis strategies provide more removal of those compounds than standard hemodialysis. We evaluated the evolution of protein-bound uremic solutes after a switch from high-flux hemodialysis to postdilution hemodiafiltration (n = 13). We compared predialysis solute concentration at 4, 5, and 9 weeks versus baseline for several protein-bound compounds and water-soluble solutes, as well as for beta(2)-microglobulin. After 9 weeks of postdilution hemodiafiltration, a significant decrease versus baseline could be detected for total concentration of protein-bound solutes: p-cresylsulfate (3.98 +/- 1.51-3.17 +/- 1.77 mg/dL, -20\%, P {\textlangle} 0.01) and 3-carboxyl-4-methyl-5-propyl-2-furanpropionic acid (0.72 +/- 0.52-0.64 +/- 0.46 mg/dL, -11\%, P {\textlangle} 0.01). For the other protein-bound solutes, hippuric acid, indoleacetic acid, and indoxylsulfate, no change in total concentration could be detected. The concentration of the middle molecule, beta(2)-microglobulin, decreased as well after 9 weeks of postdilution hemodiafiltration (24.7 +/- 9.3-18.1 +/- 6.7 mg/L, -27\%, P {\textlangle} 0.01). For water-soluble compounds, no significant change of concentration was found. Postdilution hemodiafiltration in comparison to high-flux hemodialysis provided significant reduction of predialysis concentration of protein-bound compounds, especially those with the highest protein binding, and of beta(2)-microglobulin, by -11 to -27\% in 9 weeks.},
  author       = {Meert, Natalie and WATERLOOS, MARIA and VAN LANDSCHOOT, MARIA and Dhondt, Annemieke and Ledebo, Ingid and Glorieux, Griet and Goeman, Jan and Van der Eycken, Johan and Vanholder, Raymond},
  issn         = {0160-564X},
  journal      = {ARTIFICIAL ORGANS},
  keyword      = {INDOXYL SULFATE,HEMODIALYSIS-PATIENTS,FREE P-CRESOL,Protein binding,Uremic toxins,Postdilution,Hemodialysis,Hemodiafiltration,FLUX HEMODIALYSIS,REMOVAL,TOXINS,DISEASE},
  language     = {eng},
  number       = {7},
  pages        = {580--585},
  title        = {Prospective evaluation of the change of predialysis protein-bound uremic solute concentration with postdilution online hemodiafiltration},
  url          = {http://dx.doi.org/10.1111/j.1525-1594.2010.01005.x},
  volume       = {34},
  year         = {2010},
}

Chicago
Meert, Natalie, Maria Waterloos, Maria Van Landschoot, Annemieke Dhondt, Ingid Ledebo, Griet Glorieux, Jan Goeman, Johan Van der Eycken, and Raymond Vanholder. 2010. “Prospective Evaluation of the Change of Predialysis Protein-bound Uremic Solute Concentration with Postdilution Online Hemodiafiltration.” Artificial Organs 34 (7): 580–585.
APA
Meert, N., Waterloos, M., Van Landschoot, M., Dhondt, A., Ledebo, I., Glorieux, G., Goeman, J., et al. (2010). Prospective evaluation of the change of predialysis protein-bound uremic solute concentration with postdilution online hemodiafiltration. ARTIFICIAL ORGANS, 34(7), 580–585.
Vancouver
1.
Meert N, Waterloos M, Van Landschoot M, Dhondt A, Ledebo I, Glorieux G, et al. Prospective evaluation of the change of predialysis protein-bound uremic solute concentration with postdilution online hemodiafiltration. ARTIFICIAL ORGANS. 2010;34(7):580–5.
MLA
Meert, Natalie, Maria Waterloos, Maria Van Landschoot, et al. “Prospective Evaluation of the Change of Predialysis Protein-bound Uremic Solute Concentration with Postdilution Online Hemodiafiltration.” ARTIFICIAL ORGANS 34.7 (2010): 580–585. Print.