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Investigation of early suicide-related symptoms in a non-suicidal depressed patient population after Escitalopram administration: a pilot study

EUGENIA KNOPS UGent, Gilbert Lemmens UGent, Cornelis Van Heeringen UGent, Kurt Audenaert UGent, Ellen Deschepper UGent and Dirk De Bacquer UGent (2010) INTERNET JOURNAL OF MENTAL HEALTH. 6(2). p.1-20
abstract
Background: The efficacy of selective serotonin reuptake inhibitors (SSRIs) is well established in the treatment of major depression. However, an important delay in the onset of global action relative to placebo is described within the first weeks after their administration. Little is known about the experience over time on specific and suicide-related symptoms. Aims: This study aimed at investigating the experience over time of escitalopram on depression-related symptoms that are also associated with increased risk for suicidal behaviour. Methods: In an 8-week prospective uncontrolled open-label design, escitalopram was administered to 18 patients with a current major depressive episode. Mood, state anxiety, state anger and hopelessness were assessed at baseline and after 2, 4 and 8 weeks of treatment with escitalopram in a flexible dose regimen up to 20 mg. Results: Mood (p < 0.001), state anxiety (p = 0.002), state anger (p = 0.002) and hopelessness (p = 0.002) significantly improved after 8 weeks of treatment with escitalopram. However, symptom improvement varied over time. Mood and anger significantly improved after 2 weeks of treatment, whereas significant reductions of state anxiety and hopelessness were noticed only by the end of the study.Conclusions: This study underlines the early beneficial experience of treatment with escitalopram on mood and different suicide-related symptoms in a non-suicidal depressed patient group.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
INTERNET JOURNAL OF MENTAL HEALTH
Internet J. Mental Health
volume
6
issue
2
pages
1 - 20
ISSN
1531-2941
language
English
UGent publication?
yes
classification
A2
copyright statement
I have transferred the copyright for this publication to the publisher
id
1174690
handle
http://hdl.handle.net/1854/LU-1174690
date created
2011-02-28 11:18:01
date last changed
2016-12-19 15:46:42
@article{1174690,
  abstract     = {Background: The efficacy of selective serotonin reuptake inhibitors (SSRIs) is well established in the treatment of major depression. However, an important delay in the onset of global action relative to placebo is described within the first weeks after their administration. Little is known about the experience over time on specific and suicide-related symptoms. Aims: This study aimed at investigating the experience over time of escitalopram on depression-related symptoms that are also associated with increased risk for suicidal behaviour. Methods: In an 8-week prospective uncontrolled open-label design, escitalopram was administered to 18 patients with a current major depressive episode. Mood, state anxiety, state anger and hopelessness were assessed at baseline and after 2, 4 and 8 weeks of treatment with escitalopram in a flexible dose regimen up to 20 mg. Results: Mood (p {\textlangle} 0.001), state anxiety (p = 0.002), state anger (p = 0.002) and hopelessness (p = 0.002) significantly improved after 8 weeks of treatment with escitalopram. However, symptom improvement varied over time. Mood and anger significantly improved after 2 weeks of treatment, whereas significant reductions of state anxiety and hopelessness were noticed only by the end of the study.Conclusions: This study underlines the early beneficial experience of treatment with escitalopram on mood and different suicide-related symptoms in a non-suicidal depressed patient group.},
  author       = {KNOPS, EUGENIA and Lemmens, Gilbert and Van Heeringen, Cornelis and Audenaert, Kurt and Deschepper, Ellen and De Bacquer, Dirk},
  issn         = {1531-2941},
  journal      = {INTERNET JOURNAL OF MENTAL HEALTH},
  language     = {eng},
  number       = {2},
  pages        = {1--20},
  title        = {Investigation of early suicide-related symptoms in a non-suicidal depressed patient population after Escitalopram administration: a pilot study},
  volume       = {6},
  year         = {2010},
}

Chicago
KNOPS, EUGENIA, Gilbert Lemmens, Cornelis Van Heeringen, Kurt Audenaert, Ellen Deschepper, and Dirk De Bacquer. 2010. “Investigation of Early Suicide-related Symptoms in a Non-suicidal Depressed Patient Population After Escitalopram Administration: a Pilot Study.” Internet Journal of Mental Health 6 (2): 1–20.
APA
KNOPS, E., Lemmens, G., Van Heeringen, C., Audenaert, K., Deschepper, E., & De Bacquer, D. (2010). Investigation of early suicide-related symptoms in a non-suicidal depressed patient population after Escitalopram administration: a pilot study. INTERNET JOURNAL OF MENTAL HEALTH, 6(2), 1–20.
Vancouver
1.
KNOPS E, Lemmens G, Van Heeringen C, Audenaert K, Deschepper E, De Bacquer D. Investigation of early suicide-related symptoms in a non-suicidal depressed patient population after Escitalopram administration: a pilot study. INTERNET JOURNAL OF MENTAL HEALTH. 2010;6(2):1–20.
MLA
KNOPS, EUGENIA, Gilbert Lemmens, Cornelis Van Heeringen, et al. “Investigation of Early Suicide-related Symptoms in a Non-suicidal Depressed Patient Population After Escitalopram Administration: a Pilot Study.” INTERNET JOURNAL OF MENTAL HEALTH 6.2 (2010): 1–20. Print.