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Intracellular NOD-like receptors in host defense and disease

Thirumala-Devi Kanneganti, Mohamed Lamkanfi UGent and Gabriel Nunez (2007) IMMUNITY. 27(4). p.549-559
abstract
The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1 -like receptors (RLRs). TLRs recognize microbes on the cell surface and in enclosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we discuss the recent understanding in NLRs. Two NLRs, NOW and NOD2, sense the cytosolic presence of the pepticloglycan fragments meso-DAP and muramyl dipeptide, respectively, and drive the activation of mitogen-activated protein kinase (MAPK) and the transcription factor NF-B-K. A different set of NLRs induces caspase-1 activation through the assembly of large protein complexes named inflammasomes. Genetic variations in several NLR members are associated with the development of inflammatory disorders. Further understanding of NLRs should provide new insights into the mechanisms of host defense and the pathogenesis of inflammatory diseases.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CASPASE-1 ACTIVATION, NF-KAPPA-B, ACTIVATION, TOLL-LIKE RECEPTORS, LEGIONELLA-PNEUMOPHILA INFECTION, COLD AUTOINFLAMMATORY SYNDROME, STEM-CELL TRANSPLANTATION, INNATE IMMUNE-RESPONSES, ANTHRAX LETHAL TOXIN, NUCLEOTIDE-BINDING, CROHNS-DISEASE, NUCLEOTIDE-BINDING
journal title
IMMUNITY
Immunity
volume
27
issue
4
pages
549 - 559
Web of Science type
Review
Web of Science id
000250490700007
JCR category
IMMUNOLOGY
JCR impact factor
19.266 (2007)
JCR rank
4/117 (2007)
JCR quartile
1 (2007)
ISSN
1074-7613
DOI
10.1016/j.immuni.2007.10.002
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1174588
handle
http://hdl.handle.net/1854/LU-1174588
date created
2011-02-28 11:05:30
date last changed
2016-12-19 15:43:42
@article{1174588,
  abstract     = {The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1 -like receptors (RLRs). TLRs recognize microbes on the cell surface and in enclosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we discuss the recent understanding in NLRs. Two NLRs, NOW and NOD2, sense the cytosolic presence of the pepticloglycan fragments meso-DAP and muramyl dipeptide, respectively, and drive the activation of mitogen-activated protein kinase (MAPK) and the transcription factor NF-B-K. A different set of NLRs induces caspase-1 activation through the assembly of large protein complexes named inflammasomes. Genetic variations in several NLR members are associated with the development of inflammatory disorders. Further understanding of NLRs should provide new insights into the mechanisms of host defense and the pathogenesis of inflammatory diseases.},
  author       = {Kanneganti, Thirumala-Devi and Lamkanfi, Mohamed and Nunez, Gabriel},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keyword      = {CASPASE-1 ACTIVATION,NF-KAPPA-B,ACTIVATION,TOLL-LIKE RECEPTORS,LEGIONELLA-PNEUMOPHILA INFECTION,COLD AUTOINFLAMMATORY SYNDROME,STEM-CELL TRANSPLANTATION,INNATE IMMUNE-RESPONSES,ANTHRAX LETHAL TOXIN,NUCLEOTIDE-BINDING,CROHNS-DISEASE,NUCLEOTIDE-BINDING},
  language     = {eng},
  number       = {4},
  pages        = {549--559},
  title        = {Intracellular NOD-like receptors in host defense and disease},
  url          = {http://dx.doi.org/10.1016/j.immuni.2007.10.002},
  volume       = {27},
  year         = {2007},
}

Chicago
Kanneganti, Thirumala-Devi, Mohamed Lamkanfi, and Gabriel Nunez. 2007. “Intracellular NOD-like Receptors in Host Defense and Disease.” Immunity 27 (4): 549–559.
APA
Kanneganti, T.-D., Lamkanfi, M., & Nunez, G. (2007). Intracellular NOD-like receptors in host defense and disease. IMMUNITY, 27(4), 549–559.
Vancouver
1.
Kanneganti T-D, Lamkanfi M, Nunez G. Intracellular NOD-like receptors in host defense and disease. IMMUNITY. 2007;27(4):549–59.
MLA
Kanneganti, Thirumala-Devi, Mohamed Lamkanfi, and Gabriel Nunez. “Intracellular NOD-like Receptors in Host Defense and Disease.” IMMUNITY 27.4 (2007): 549–559. Print.