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Intracellular NOD-like receptors in host defense and disease

(2007) IMMUNITY. 27(4). p.549-559
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Organization
Abstract
The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1 -like receptors (RLRs). TLRs recognize microbes on the cell surface and in enclosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we discuss the recent understanding in NLRs. Two NLRs, NOW and NOD2, sense the cytosolic presence of the pepticloglycan fragments meso-DAP and muramyl dipeptide, respectively, and drive the activation of mitogen-activated protein kinase (MAPK) and the transcription factor NF-B-K. A different set of NLRs induces caspase-1 activation through the assembly of large protein complexes named inflammasomes. Genetic variations in several NLR members are associated with the development of inflammatory disorders. Further understanding of NLRs should provide new insights into the mechanisms of host defense and the pathogenesis of inflammatory diseases.
Keywords
CASPASE-1 ACTIVATION, NF-KAPPA-B, ACTIVATION, TOLL-LIKE RECEPTORS, LEGIONELLA-PNEUMOPHILA INFECTION, COLD AUTOINFLAMMATORY SYNDROME, STEM-CELL TRANSPLANTATION, INNATE IMMUNE-RESPONSES, ANTHRAX LETHAL TOXIN, NUCLEOTIDE-BINDING, CROHNS-DISEASE, NUCLEOTIDE-BINDING

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Citation

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Chicago
Kanneganti, Thirumala-Devi, Mohamed Lamkanfi, and Gabriel Nunez. 2007. “Intracellular NOD-like Receptors in Host Defense and Disease.” Immunity 27 (4): 549–559.
APA
Kanneganti, T.-D., Lamkanfi, M., & Nunez, G. (2007). Intracellular NOD-like receptors in host defense and disease. IMMUNITY, 27(4), 549–559.
Vancouver
1.
Kanneganti T-D, Lamkanfi M, Nunez G. Intracellular NOD-like receptors in host defense and disease. IMMUNITY. 2007;27(4):549–59.
MLA
Kanneganti, Thirumala-Devi, Mohamed Lamkanfi, and Gabriel Nunez. “Intracellular NOD-like Receptors in Host Defense and Disease.” IMMUNITY 27.4 (2007): 549–559. Print.
@article{1174588,
  abstract     = {The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1 -like receptors (RLRs). TLRs recognize microbes on the cell surface and in enclosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we discuss the recent understanding in NLRs. Two NLRs, NOW and NOD2, sense the cytosolic presence of the pepticloglycan fragments meso-DAP and muramyl dipeptide, respectively, and drive the activation of mitogen-activated protein kinase (MAPK) and the transcription factor NF-B-K. A different set of NLRs induces caspase-1 activation through the assembly of large protein complexes named inflammasomes. Genetic variations in several NLR members are associated with the development of inflammatory disorders. Further understanding of NLRs should provide new insights into the mechanisms of host defense and the pathogenesis of inflammatory diseases.},
  author       = {Kanneganti, Thirumala-Devi and Lamkanfi, Mohamed and Nunez, Gabriel},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keyword      = {CASPASE-1 ACTIVATION,NF-KAPPA-B,ACTIVATION,TOLL-LIKE RECEPTORS,LEGIONELLA-PNEUMOPHILA INFECTION,COLD AUTOINFLAMMATORY SYNDROME,STEM-CELL TRANSPLANTATION,INNATE IMMUNE-RESPONSES,ANTHRAX LETHAL TOXIN,NUCLEOTIDE-BINDING,CROHNS-DISEASE,NUCLEOTIDE-BINDING},
  language     = {eng},
  number       = {4},
  pages        = {549--559},
  title        = {Intracellular NOD-like receptors in host defense and disease},
  url          = {http://dx.doi.org/10.1016/j.immuni.2007.10.002},
  volume       = {27},
  year         = {2007},
}

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