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Twenty-six years of meniscal allograft transplantation: is it still experimental?: a meta-analysis of 44 trials

Mohamed ElAttar, Aad Dhollander UGent, René Verdonk UGent, Karl Almqvist UGent and Peter Verdonk UGent (2011) KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 19(2). p.147-157
abstract
Since the first meniscal allograft transplantation in 1984, thousands of patients with postmeniscectomy symptoms have been treated by allograft replacement. This study aims the collection, presentation and meta-analysis of published trials reporting outcomes of meniscal allograft transplantation to establish its safety and reproducibility. A literature search was conducted and the abstracts of all English-language trials with a more than 6 months' clinical, radiological and/or histological follow-up in human subjects were reviewed. Forty-four trials representing 1,136 grafts in 1,068 patients were analyzed. To assess the methodological quality of the collected data, original and modified Coleman methodology scores were determined for all included papers. The outcomes of 678 medial and 458 lateral grafts in 613 male, 265 female and 190 nondefined patients with a mean age of 34.8 years were presented. The outcome was assessed using 12 scoring systems, 4 imaging modalities, second-look arthroscopy and/or histological analysis. Whatever the follow-up period and the scoring system used, patients continuously showed clinical improvement. The average original Coleman scores were 45.9 +/- A 8.4 (range 25-59). The average modified Coleman scores were 43.7 +/- A 9.1 (range 24-62). All studies reported a continuously satisfactory outcome with restoration of working capacity in these active patients. The complication and failure rates are considered acceptable by all authors. Salvage procedures included osteotomy and arthroplasty without secondary difficulties. Meniscal allograft transplantation can be considered as safe and reliable for the treatment of refractory postmeniscectomy symptoms in selected patients.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Allograft, Meta-analysis, Transplantation, Transplant, Meniscal, Meniscus, ANTERIOR CRUCIATE LIGAMENT, 2-YEAR FOLLOW-UP, AUTOLOGOUS CHONDROCYTE IMPLANTATION, MEDIAL MENISCECTOMY, CLINICAL-OUTCOMES, CARTILAGE REPAIR, KNEE, RECONSTRUCTION, MINIMUM, REPLACEMENT
journal title
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
Knee Surg. Sports Traumatol. Arthrosc.
volume
19
issue
2
pages
147 - 157
Web of Science type
Article
Web of Science id
000286436400002
JCR category
SPORT SCIENCES
JCR impact factor
2.209 (2011)
JCR rank
17/83 (2011)
JCR quartile
1 (2011)
ISSN
0942-2056
DOI
10.1007/s00167-010-1351-6
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1170965
handle
http://hdl.handle.net/1854/LU-1170965
date created
2011-02-25 11:43:56
date last changed
2011-04-01 09:08:09
@article{1170965,
  abstract     = {Since the first meniscal allograft transplantation in 1984, thousands of patients with postmeniscectomy symptoms have been treated by allograft replacement. This study aims the collection, presentation and meta-analysis of published trials reporting outcomes of meniscal allograft transplantation to establish its safety and reproducibility.
A literature search was conducted and the abstracts of all English-language trials with a more than 6 months' clinical, radiological and/or histological follow-up in human subjects were reviewed. Forty-four trials representing 1,136 grafts in 1,068 patients were analyzed. To assess the methodological quality of the collected data, original and modified Coleman methodology scores were determined for all included papers.
The outcomes of 678 medial and 458 lateral grafts in 613 male, 265 female and 190 nondefined patients with a mean age of 34.8 years were presented. The outcome was assessed using 12 scoring systems, 4 imaging modalities, second-look arthroscopy and/or histological analysis. Whatever the follow-up period and the scoring system used, patients continuously showed clinical improvement. The average original Coleman scores were 45.9 +/- A 8.4 (range 25-59). The average modified Coleman scores were 43.7 +/- A 9.1 (range 24-62).
All studies reported a continuously satisfactory outcome with restoration of working capacity in these active patients. The complication and failure rates are considered acceptable by all authors. Salvage procedures included osteotomy and arthroplasty without secondary difficulties. Meniscal allograft transplantation can be considered as safe and reliable for the treatment of refractory postmeniscectomy symptoms in selected patients.},
  author       = {ElAttar, Mohamed and Dhollander, Aad and Verdonk, Ren{\'e} and Almqvist, Karl and Verdonk, Peter},
  issn         = {0942-2056},
  journal      = {KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY},
  keyword      = {Allograft,Meta-analysis,Transplantation,Transplant,Meniscal,Meniscus,ANTERIOR CRUCIATE LIGAMENT,2-YEAR FOLLOW-UP,AUTOLOGOUS CHONDROCYTE IMPLANTATION,MEDIAL MENISCECTOMY,CLINICAL-OUTCOMES,CARTILAGE REPAIR,KNEE,RECONSTRUCTION,MINIMUM,REPLACEMENT},
  language     = {eng},
  number       = {2},
  pages        = {147--157},
  title        = {Twenty-six years of meniscal allograft transplantation: is it still experimental?: a meta-analysis of 44 trials},
  url          = {http://dx.doi.org/10.1007/s00167-010-1351-6},
  volume       = {19},
  year         = {2011},
}

Chicago
ElAttar, Mohamed, AAD DHOLLANDER, René Verdonk, Karl Almqvist, and Peter Verdonk. 2011. “Twenty-six Years of Meniscal Allograft Transplantation: Is It Still Experimental?: a Meta-analysis of 44 Trials.” Knee Surgery Sports Traumatology Arthroscopy 19 (2): 147–157.
APA
ElAttar, M., DHOLLANDER, A., Verdonk, R., Almqvist, K., & Verdonk, P. (2011). Twenty-six years of meniscal allograft transplantation: is it still experimental?: a meta-analysis of 44 trials. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 19(2), 147–157.
Vancouver
1.
ElAttar M, DHOLLANDER A, Verdonk R, Almqvist K, Verdonk P. Twenty-six years of meniscal allograft transplantation: is it still experimental?: a meta-analysis of 44 trials. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 2011;19(2):147–57.
MLA
ElAttar, Mohamed, AAD DHOLLANDER, René Verdonk, et al. “Twenty-six Years of Meniscal Allograft Transplantation: Is It Still Experimental?: a Meta-analysis of 44 Trials.” KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 19.2 (2011): 147–157. Print.