Advanced search
1 file | 188.50 KB Add to list

Efficacy, tolerability and safety of nebivolol in patients with hypertension and diabetes: a post-marketing surveillance study

Author
Organization
Abstract
Background and Objectives: Hypertension is a widely prevalent condition of elevated blood pressure (BP) and is the leading risk factor for the development of cardiovascular disease (CVD). Many patients have additional risk factors such as diabetes mellitus (DM) or previous history of CVD. Nebivolol is a third-generation beta (beta)-blockers which has been shown not to influence metabolic parameters in patients with DM. This post-marketing surveillance study aimed to collect information on the efficacy, safety and tolerability of nebivolol in hypertensive patients with concomitant DM. Patients and Methods: Hypertensive patients with DM followed by 52 cardiologists, internal medicine specialists and general practitioners, between :24 August 2003 and 9 January 2007 in the Netherlands were included in this study. Physicians were asked to survey nebivolol treatment for 6 months. Results: A total of 510 patients were enrolled. Overall, 93.3% of patients were diagnosed with essential hypertension and 6.7% with secondary hypertension. All patients were co-diagnosed with DM. Nebivolol therapy was associated with a significant reduction in both systolic blood pressure (BP) and diastolic BP versus baseline (p<0.001 for both). These reductions were seen regardless of reason for initiation of nebivolol (i.e. first diagnosis of hypertension, resistance or intolerance to previous antihypertensive medication, or other reasons). A significant improvement in blood glucose was seen at 4 months (-0.6 mmol/L; p=0.021). Significant reductions in total cholesterol (-1.45 mmol/L; p=0.006), low density lipoprotein (LDL) cholesterol (-1.32 mmol/L; p=0.003) and LDL/high density lipoprotein (HDL) cholesterol ratio (-0.77; p=0.011) were observed at 2 months. No significant changes were seen in HDL cholesterol and triglycerides. Conclusion: Nebivolol treatment was associated with a significantly reduced BP, improved blood glucose and LDL cholesterol levels and was well tolerated in hypertensive patients with concomitant DM.
Keywords
Glycaemic profile, Diabetes, Hypertension, Nebivolol, Lipidic profile, ARTERIAL-HYPERTENSION, BETA-BLOCKERS, ANTIHYPERTENSIVE THERAPY, EUROPEAN-SOCIETY, GLYCEMIC CONTROL, BLOOD-PRESSURE, MANAGEMENT, GUIDELINES, MELLITUS, ATENOLOL

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 188.50 KB

Citation

Please use this url to cite or link to this publication:

MLA
Van Bortel, Lucas. “Efficacy, Tolerability and Safety of Nebivolol in Patients with Hypertension and Diabetes: A Post-Marketing Surveillance Study.” EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol. 14, no. 9, 2010, pp. 749–58.
APA
Van Bortel, L. (2010). Efficacy, tolerability and safety of nebivolol in patients with hypertension and diabetes: a post-marketing surveillance study. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 14(9), 749–758.
Chicago author-date
Van Bortel, Lucas. 2010. “Efficacy, Tolerability and Safety of Nebivolol in Patients with Hypertension and Diabetes: A Post-Marketing Surveillance Study.” EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 14 (9): 749–58.
Chicago author-date (all authors)
Van Bortel, Lucas. 2010. “Efficacy, Tolerability and Safety of Nebivolol in Patients with Hypertension and Diabetes: A Post-Marketing Surveillance Study.” EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 14 (9): 749–758.
Vancouver
1.
Van Bortel L. Efficacy, tolerability and safety of nebivolol in patients with hypertension and diabetes: a post-marketing surveillance study. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. 2010;14(9):749–58.
IEEE
[1]
L. Van Bortel, “Efficacy, tolerability and safety of nebivolol in patients with hypertension and diabetes: a post-marketing surveillance study,” EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol. 14, no. 9, pp. 749–758, 2010.
@article{1167051,
  abstract     = {{Background and Objectives: Hypertension is a widely prevalent condition of elevated blood pressure (BP) and is the leading risk factor for the development of cardiovascular disease (CVD). Many patients have additional risk factors such as diabetes mellitus (DM) or previous history of CVD. Nebivolol is a third-generation beta (beta)-blockers which has been shown not to influence metabolic parameters in patients with DM. This post-marketing surveillance study aimed to collect information on the efficacy, safety and tolerability of nebivolol in hypertensive patients with concomitant DM.
Patients and Methods: Hypertensive patients with DM followed by 52 cardiologists, internal medicine specialists and general practitioners, between :24 August 2003 and 9 January 2007 in the Netherlands were included in this study. Physicians were asked to survey nebivolol treatment for 6 months.
Results: A total of 510 patients were enrolled. Overall, 93.3% of patients were diagnosed with essential hypertension and 6.7% with secondary hypertension. All patients were co-diagnosed with DM. Nebivolol therapy was associated with a significant reduction in both systolic blood pressure (BP) and diastolic BP versus baseline (p<0.001 for both). These reductions were seen regardless of reason for initiation of nebivolol (i.e. first diagnosis of hypertension, resistance or intolerance to previous antihypertensive medication, or other reasons). A significant improvement in blood glucose was seen at 4 months (-0.6 mmol/L; p=0.021). Significant reductions in total cholesterol (-1.45 mmol/L; p=0.006), low density lipoprotein (LDL) cholesterol (-1.32 mmol/L; p=0.003) and LDL/high density lipoprotein (HDL) cholesterol ratio (-0.77; p=0.011) were observed at 2 months. No significant changes were seen in HDL cholesterol and triglycerides.
Conclusion: Nebivolol treatment was associated with a significantly reduced BP, improved blood glucose and LDL cholesterol levels and was well tolerated in hypertensive patients with concomitant DM.}},
  author       = {{Van Bortel, Lucas}},
  issn         = {{1128-3602}},
  journal      = {{EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES}},
  keywords     = {{Glycaemic profile,Diabetes,Hypertension,Nebivolol,Lipidic profile,ARTERIAL-HYPERTENSION,BETA-BLOCKERS,ANTIHYPERTENSIVE THERAPY,EUROPEAN-SOCIETY,GLYCEMIC CONTROL,BLOOD-PRESSURE,MANAGEMENT,GUIDELINES,MELLITUS,ATENOLOL}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{749--758}},
  title        = {{Efficacy, tolerability and safety of nebivolol in patients with hypertension and diabetes: a post-marketing surveillance study}},
  volume       = {{14}},
  year         = {{2010}},
}

Web of Science
Times cited: