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External quality assessment of multi-analyte chromatographic methods in oral fluid

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Abstract
Objectives: DRUID (Driving Under the Inflluence of Drugs, Alcohol and Medicines) is a research project funded by the European Commission in which oral fluid is analysed by eleven laboratories. A common collection and analysis methodology has been used: collection with Statsure Saliva Sampler and LC-MS/MS or GC-MS analysis of 22 substances. Four rounds of proficiency testing (PT) were organized between March 2008 and September 2009. Methods: Qualitative results were evaluated using sensitivity and specificity. Quantitative results were evaluated using z-scores and the standard deviation of Horwitz. Results: Specificity was above 99% for all analytes; sensitivity per analyte varied between 81.7 and 100%, 20 out of 22 analytes had a sensitivity >90%. The percentage of satisfactory z-scores increased from 79.4% to 89.2% over the test period. This trend was seen for all drugs, except zopiclone. Results were discussed with participating laboratories and problems were addressed. Conclusions: Because of these corrective actions, DRUID laboratories have a lower variation in results than previously published PT schemes in oral fluid.

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MLA
Verstraete, Alain, et al. “External Quality Assessment of Multi-Analyte Chromatographic Methods in Oral Fluid.” Tri-Annual Meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts, 2010, pp. 169–169.
APA
Verstraete, A., Pil, K., & Esposito, F. (2010). External quality assessment of multi-analyte chromatographic methods in oral fluid. In Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts (pp. 169–169). Oslo, Norway.
Chicago author-date
Verstraete, Alain, Kristof Pil, and Francis Esposito. 2010. “External Quality Assessment of Multi-Analyte Chromatographic Methods in Oral Fluid.” In Tri-Annual Meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts, 169–169.
Chicago author-date (all authors)
Verstraete, Alain, Kristof Pil, and Francis Esposito. 2010. “External Quality Assessment of Multi-Analyte Chromatographic Methods in Oral Fluid.” In Tri-Annual Meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts, 169–169.
Vancouver
1.
Verstraete A, Pil K, Esposito F. External quality assessment of multi-analyte chromatographic methods in oral fluid. In: Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts. 2010. p. 169–169.
IEEE
[1]
A. Verstraete, K. Pil, and F. Esposito, “External quality assessment of multi-analyte chromatographic methods in oral fluid,” in Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts, Oslo, Norway, 2010, pp. 169–169.
@inproceedings{1166607,
  abstract     = {{Objectives: DRUID (Driving Under the Inflluence of Drugs, Alcohol and Medicines) is a research project funded by the European Commission in which oral fluid is analysed by eleven laboratories. A common collection and analysis methodology has been used: collection with Statsure Saliva Sampler and LC-MS/MS or GC-MS analysis of 22 substances. Four rounds of proficiency testing (PT) were organized between March 2008 and September 2009.
Methods: Qualitative results were evaluated using sensitivity and specificity. Quantitative results were evaluated using z-scores and the standard deviation of Horwitz.
Results: Specificity was above 99% for all analytes; sensitivity per analyte varied between 81.7 and 100%, 20 out of 22 analytes had a sensitivity >90%. The percentage of satisfactory z-scores increased from 79.4% to 89.2% over the test period. This trend was seen for all drugs, except zopiclone. Results were discussed with participating laboratories and problems were addressed. 
Conclusions: Because of these corrective actions, DRUID laboratories have a lower variation in results than previously published PT schemes in oral fluid.}},
  author       = {{Verstraete, Alain and Pil, Kristof and Esposito, Francis}},
  booktitle    = {{Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts}},
  language     = {{eng}},
  location     = {{Oslo, Norway}},
  pages        = {{169--169}},
  title        = {{External quality assessment of multi-analyte chromatographic methods in oral fluid}},
  year         = {{2010}},
}