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External quality assessment of multi-analyte chromatographic methods in oral fluid

Alain Verstraete UGent, Kristof Pil UGent and Francis Esposito (2010) Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts. p.169-169
abstract
Objectives: DRUID (Driving Under the Inflluence of Drugs, Alcohol and Medicines) is a research project funded by the European Commission in which oral fluid is analysed by eleven laboratories. A common collection and analysis methodology has been used: collection with Statsure Saliva Sampler and LC-MS/MS or GC-MS analysis of 22 substances. Four rounds of proficiency testing (PT) were organized between March 2008 and September 2009. Methods: Qualitative results were evaluated using sensitivity and specificity. Quantitative results were evaluated using z-scores and the standard deviation of Horwitz. Results: Specificity was above 99% for all analytes; sensitivity per analyte varied between 81.7 and 100%, 20 out of 22 analytes had a sensitivity >90%. The percentage of satisfactory z-scores increased from 79.4% to 89.2% over the test period. This trend was seen for all drugs, except zopiclone. Results were discussed with participating laboratories and problems were addressed. Conclusions: Because of these corrective actions, DRUID laboratories have a lower variation in results than previously published PT schemes in oral fluid.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
in
Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts
pages
169 - 169
conference name
Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS)
conference location
Oslo, Norway
conference start
2010-08-22
conference end
2010-08-26
project
DRUID - Driving Under the Influence of Drugs and Medicines
language
English
UGent publication?
yes
classification
C3
copyright statement
I have retained and own the full copyright for this publication
id
1166607
handle
http://hdl.handle.net/1854/LU-1166607
date created
2011-02-23 12:22:24
date last changed
2016-12-19 15:36:52
@inproceedings{1166607,
  abstract     = {Objectives: DRUID (Driving Under the Inflluence of Drugs, Alcohol and Medicines) is a research project funded by the European Commission in which oral fluid is analysed by eleven laboratories. A common collection and analysis methodology has been used: collection with Statsure Saliva Sampler and LC-MS/MS or GC-MS analysis of 22 substances. Four rounds of proficiency testing (PT) were organized between March 2008 and September 2009.
Methods: Qualitative results were evaluated using sensitivity and specificity. Quantitative results were evaluated using z-scores and the standard deviation of Horwitz.
Results: Specificity was above 99\% for all analytes; sensitivity per analyte varied between 81.7 and 100\%, 20 out of 22 analytes had a sensitivity {\textrangle}90\%. The percentage of satisfactory z-scores increased from 79.4\% to 89.2\% over the test period. This trend was seen for all drugs, except zopiclone. Results were discussed with participating laboratories and problems were addressed. 
Conclusions: Because of these corrective actions, DRUID laboratories have a lower variation in results than previously published PT schemes in oral fluid.},
  author       = {Verstraete, Alain and Pil, Kristof and Esposito, Francis},
  booktitle    = {Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts},
  language     = {eng},
  location     = {Oslo, Norway},
  pages        = {169--169},
  title        = {External quality assessment of multi-analyte chromatographic methods in oral fluid},
  year         = {2010},
}

Chicago
Verstraete, Alain, Kristof Pil, and Francis Esposito. 2010. “External Quality Assessment of Multi-analyte Chromatographic Methods in Oral Fluid.” In Tri-annual Meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts, 169–169.
APA
Verstraete, Alain, Pil, K., & Esposito, F. (2010). External quality assessment of multi-analyte chromatographic methods in oral fluid. Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts (pp. 169–169). Presented at the Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS).
Vancouver
1.
Verstraete A, Pil K, Esposito F. External quality assessment of multi-analyte chromatographic methods in oral fluid. Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts. 2010. p. 169–169.
MLA
Verstraete, Alain, Kristof Pil, and Francis Esposito. “External Quality Assessment of Multi-analyte Chromatographic Methods in Oral Fluid.” Tri-annual Meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts. 2010. 169–169. Print.