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Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants

(2010) MALARIA JOURNAL. 9(209).
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Abstract
Objectives: To compare three methods for evaluating treatment adherence in a 7-day controlled treatment period for malaria in children in Rwanda. Methods: Fifty-six children (< 5 years) with malaria were recruited at the University Hospital of Butare, Rwanda. Patients were treated with quinine sulfate, taste-masked, pellets during seven days: three days in hospital (in-patient) followed by a four-day out-patient period. Three methods to evaluate medication adherence among patients were compared: manual pill count of returned tablets, patient self-report and electronic pill-box monitoring. These pill-boxes were equipped with a microchip registering date and time of every opening. Medication adherence was defined as the proportion of prescribed doses taken. The inter-dose intervals were analysed as well. Results: Medication adherence data were available for 54 of the 56 patients. Manual pill count and patient self-report yielded a medication adherence of 100% for the in-and out-patient treatment periods. Based on electronic pill-box monitoring, medication adherence during the seven-day treatment period was 90.5 +/- 8.3%. Based on electronic pillbox monitoring inpatient medication adherence (99.3 +/- 2.7%) was markedly higher (p < 0.03) than out-patient adherence (82.7 +/- 14.7%), showing a clear difference between health workers' and consumers' medication adherence. Conclusion: Health workers' medication adherence was good. However, a significant lower medication adherence was observed for consumers' adherence in the outpatient setting. This was only detected by electronic pill-box monitoring. Therefore, this latter method is more accurate than the two other methods used in this study.
Keywords
SULFADOXINE-PYRIMETHAMINE, ARTEMETHER-LUMEFANTRINE, PATIENT, CHILDREN, THERAPY, VALIDATION, ARTESUNATE, HYPERTENSION, COMBINATION, PLASMODIUM-FALCIPARUM MALARIA

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Chicago
Twagirumukiza, Marc, Pierre Claver Kayumba, Jan Kips, Bernard Vrijens, Robert Vander Stichele, Chris Vervaet, Jean Paul Remon, and Lucas Van Bortel. 2010. “Evaluation of Medication Adherence Methods in the Treatment of Malaria in Rwandan Infants.” Malaria Journal 9 (209).
APA
Twagirumukiza, Marc, Kayumba, P. C., Kips, J., Vrijens, B., Vander Stichele, R., Vervaet, C., Remon, J. P., et al. (2010). Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants. MALARIA JOURNAL, 9(209).
Vancouver
1.
Twagirumukiza M, Kayumba PC, Kips J, Vrijens B, Vander Stichele R, Vervaet C, et al. Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants. MALARIA JOURNAL. 2010;9(209).
MLA
Twagirumukiza, Marc, Pierre Claver Kayumba, Jan Kips, et al. “Evaluation of Medication Adherence Methods in the Treatment of Malaria in Rwandan Infants.” MALARIA JOURNAL 9.209 (2010): n. pag. Print.
@article{1166379,
  abstract     = {Objectives: To compare three methods for evaluating treatment adherence in a 7-day controlled treatment period for malaria in children in Rwanda.
Methods: Fifty-six children ({\textlangle} 5 years) with malaria were recruited at the University Hospital of Butare, Rwanda. Patients were treated with quinine sulfate, taste-masked, pellets during seven days: three days in hospital (in-patient) followed by a four-day out-patient period. Three methods to evaluate medication adherence among patients were compared: manual pill count of returned tablets, patient self-report and electronic pill-box monitoring. These pill-boxes were equipped with a microchip registering date and time of every opening. Medication adherence was defined as the proportion of prescribed doses taken. The inter-dose intervals were analysed as well.
Results: Medication adherence data were available for 54 of the 56 patients. Manual pill count and patient self-report yielded a medication adherence of 100\% for the in-and out-patient treatment periods. Based on electronic pill-box monitoring, medication adherence during the seven-day treatment period was 90.5 +/- 8.3\%. Based on electronic pillbox monitoring inpatient medication adherence (99.3 +/- 2.7\%) was markedly higher (p {\textlangle} 0.03) than out-patient adherence (82.7 +/- 14.7\%), showing a clear difference between health workers' and consumers' medication adherence.
Conclusion: Health workers' medication adherence was good. However, a significant lower medication adherence was observed for consumers' adherence in the outpatient setting. This was only detected by electronic pill-box monitoring. Therefore, this latter method is more accurate than the two other methods used in this study.},
  articleno    = {209},
  author       = {Twagirumukiza, Marc and Kayumba, Pierre Claver and Kips, Jan and Vrijens, Bernard and Vander Stichele, Robert and Vervaet, Chris and Remon, Jean Paul and Van Bortel, Lucas},
  issn         = {1475-2875},
  journal      = {MALARIA JOURNAL},
  keyword      = {SULFADOXINE-PYRIMETHAMINE,ARTEMETHER-LUMEFANTRINE,PATIENT,CHILDREN,THERAPY,VALIDATION,ARTESUNATE,HYPERTENSION,COMBINATION,PLASMODIUM-FALCIPARUM MALARIA},
  language     = {eng},
  number       = {209},
  pages        = {7},
  title        = {Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants},
  url          = {http://dx.doi.org/10.1186/1475-2875-9-206},
  volume       = {9},
  year         = {2010},
}

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