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Comparison of a checklist for clinical signs of impairment and detection of drugs in saliva

Sara-Ann Legrand UGent, An-Sofie Goessaert UGent, Jolien Veramme and Alain Verstraete UGent (2010) Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts. p.171-171
abstract
Objectives: In Belgium and some other countries, the police performs on-site drug screening when a driver is suspected of being drug impaired, since the test procedure is time consuming and the screening devices are relatively expensive. The objective of the study is to compare the results of a checklist with drug concentrations in saliva. Method: The checklist used in the DRUID study in the Netherlands was used. Two fifth-year medical students performed the tests on 250 subjects, 50 drivers and 200 subjects attending a methadone clinic. Saliva analysis was performed by UPLC-MS/MS. As several signs were rarely observed, the parameters were reduced to those that were positive in at least 3 out of 250 test subjects. This selection led to a reduction to 13 (out of 28) parameters. A statistical test (Fisher’s exact test) was used to test for correlations between the checklist parameters and the presence of substances in oral fluid. Results: Most parameters did not correlate significantly with drug intake. The pupil tests seemed to be the best predicting parameters, especially for amphetamine and THC. Remarkably, some correlations were found between parameters and drugs where no correlation was expected, e.g. sleepiness and amphetamines. This can possibly be caused by the presence of combination use of drugs in a lot of subjects. The signs were often observed when high drug concentrations were seen in saliva, but in many cases with high saliva drug concentrations, no signs were observed. Conclusions: In general, the checklist correlated badly with drug presence in this population of chronic drug users, but our results also confirm other studies that found that checklists are not very sensitive.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
correlation, checklist parameters, presence of substances in oral fluid.
in
Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts
pages
171 - 171
conference name
Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS)
conference location
Oslo, Norway
conference start
2010-08-22
conference end
2010-08-26
project
DRUID - Driving Under the Influence of Drugs and Medicines
language
English
UGent publication?
yes
classification
C3
copyright statement
I have retained and own the full copyright for this publication
id
1166064
handle
http://hdl.handle.net/1854/LU-1166064
date created
2011-02-23 11:16:43
date last changed
2016-12-19 15:35:08
@inproceedings{1166064,
  abstract     = {Objectives: In Belgium and some other countries, the police performs on-site drug screening when a driver is suspected of being drug impaired, since the test procedure is time consuming and the screening devices are relatively expensive. The objective of the study is to compare the results of a checklist with drug concentrations in saliva.
Method: The checklist used in the DRUID study in the Netherlands was used. Two fifth-year medical students performed the tests on 250 subjects, 50 drivers and 200 subjects attending a methadone clinic. Saliva analysis was performed by UPLC-MS/MS. As several signs were rarely observed, the parameters were reduced to those that were positive in at least 3 out of 250 test subjects. This selection led to a reduction to 13 (out of 28) parameters. A statistical test (Fisher{\textquoteright}s exact test) was used to test for correlations between the checklist parameters and the presence of substances in oral fluid.
Results: Most parameters did not correlate significantly with drug intake. The pupil tests seemed to be the best predicting parameters, especially for amphetamine and THC. Remarkably, some correlations were found between parameters and drugs where no correlation was expected, e.g. sleepiness and amphetamines. This can possibly be caused by the presence of combination use of drugs in a lot of subjects. The signs were often observed when high drug concentrations were seen in saliva, but in many cases with high saliva drug concentrations, no signs were observed.
Conclusions: In general, the checklist correlated badly with drug presence in this population of chronic drug users, but our results also confirm other studies that found that checklists are not very sensitive.},
  author       = {Legrand, Sara-Ann and Goessaert, An-Sofie and Veramme, Jolien and Verstraete, Alain},
  booktitle    = {Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts},
  keyword      = {correlation,checklist parameters,presence of substances in oral fluid.},
  language     = {eng},
  location     = {Oslo, Norway},
  pages        = {171--171},
  title        = {Comparison of a checklist for clinical signs of impairment and detection of drugs in saliva},
  year         = {2010},
}

Chicago
Legrand, Sara-Ann, An-Sofie Goessaert, Jolien Veramme, and Alain Verstraete. 2010. “Comparison of a Checklist for Clinical Signs of Impairment and Detection of Drugs in Saliva.” In Tri-annual Meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts, 171–171.
APA
Legrand, S.-A., Goessaert, A.-S., Veramme, J., & Verstraete, A. (2010). Comparison of a checklist for clinical signs of impairment and detection of drugs in saliva. Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts (pp. 171–171). Presented at the Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS).
Vancouver
1.
Legrand S-A, Goessaert A-S, Veramme J, Verstraete A. Comparison of a checklist for clinical signs of impairment and detection of drugs in saliva. Tri-annual meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts. 2010. p. 171–171.
MLA
Legrand, Sara-Ann, An-Sofie Goessaert, Jolien Veramme, et al. “Comparison of a Checklist for Clinical Signs of Impairment and Detection of Drugs in Saliva.” Tri-annual Meeting of the International Council on Alcohol, Drugs and Traffic Society (ICADTS), Abstracts. 2010. 171–171. Print.