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Description of a large-scale study design to assess work-stress-disease associations for cardiovascular disease

Robert Karasek, Sean Collins, Els Clays UGent, Alicja Bortkiewics and Marco Ferrario (2010) INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH. 23(3). p.293-312
abstract
We claim that a new level of studies is needed to answer a series of important questions about the expanding global chronic disease burden for cardiovascular disease (CVD) and for related conditions such as diabetes, metabolic syndrome, and obesity. These require a new study design structure, related to a new level of theory that goes beyond the current single-factor, a-theoretic epidemiological studies. This new platform for the design of large-scale Work/Stress/Disease studies would assess CVD-related disease mechanisms in a more general and dynamic form, based on the use of new tools for measuring autonomic functions in an occupational stress context and a new theory of disease causation. A sample outline is presented for such a study, based on Stress-Disequilibrium Theory (SDT) hypotheses, building on analytic tools developed for the assessment of stress-related exhaustion effects and chronic disease risks from Heart Rate Variability (HRV) research studies. The goal is to assess the associations between social organizational risks, particularly at work, and hypertension, metabolic syndrome, and diabetes II. The study design is multi-stage, spanning across several levels of disease-related de-regulation, and addressing co-morbidity of the conditions themselves. The study design is meant to span across a broad social population at all levels and would probably be multi-site, involving several countries, to yield the larger sample increased power for finding associations for work — physiological effects.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Growth and regeneration, Large-scale study design, Low control, Stress, Cardiovascular disease, HEART-RATE-VARIABILITY, AMBULATORY BLOOD-PRESSURE, RISK-FACTORS, MONICA PROJECT, JOB STRAIN, ELECTROMAGNETIC-FIELDS, CORONARY RISK, TRENDS
journal title
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
Int. J. Occup. Med. Environ. Health
volume
23
issue
3
pages
293 - 312
Web of Science type
Review
Web of Science id
000287139600008
JCR category
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
JCR impact factor
1.057 (2010)
JCR rank
101/140 (2010)
JCR quartile
3 (2010)
ISSN
1232-1087
DOI
10.2478/v10001-010-0035-2
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1162235
handle
http://hdl.handle.net/1854/LU-1162235
date created
2011-02-21 13:31:38
date last changed
2015-06-17 09:26:41
@article{1162235,
  abstract     = {We claim that a new level of studies is needed to answer a series of important questions about the expanding global chronic disease burden for cardiovascular disease (CVD) and for related conditions such as diabetes, metabolic syndrome, and obesity. These require a new study design structure, related to a new level of theory that goes beyond the current single-factor, a-theoretic epidemiological studies. This new platform for the design of large-scale Work/Stress/Disease studies would assess CVD-related disease mechanisms in a more general and dynamic form, based on the use of new tools for measuring autonomic functions in an occupational stress context and a new theory of disease causation. A sample outline is presented for such a study, based on Stress-Disequilibrium Theory (SDT) hypotheses, building on analytic tools developed for the assessment of stress-related exhaustion effects and chronic disease risks from Heart Rate Variability (HRV) research studies. The goal is to assess the associations between social organizational risks, particularly at work, and hypertension, metabolic syndrome, and diabetes II. The study design is multi-stage, spanning across several levels of disease-related de-regulation, and addressing co-morbidity of the conditions themselves. The study design is meant to span across a broad social population at all levels and would probably be multi-site, involving several countries, to yield the larger sample increased power for finding associations for work --- physiological effects.},
  author       = {Karasek, Robert and Collins, Sean and Clays, Els and Bortkiewics, Alicja and Ferrario, Marco},
  issn         = {1232-1087},
  journal      = {INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH},
  keyword      = {Growth and regeneration,Large-scale study design,Low control,Stress,Cardiovascular disease,HEART-RATE-VARIABILITY,AMBULATORY BLOOD-PRESSURE,RISK-FACTORS,MONICA PROJECT,JOB STRAIN,ELECTROMAGNETIC-FIELDS,CORONARY RISK,TRENDS},
  language     = {eng},
  number       = {3},
  pages        = {293--312},
  title        = {Description of a large-scale study design to assess work-stress-disease associations for cardiovascular disease},
  url          = {http://dx.doi.org/10.2478/v10001-010-0035-2},
  volume       = {23},
  year         = {2010},
}

Chicago
Karasek, Robert, Sean Collins, Els Clays, Alicja Bortkiewics, and Marco Ferrario. 2010. “Description of a Large-scale Study Design to Assess Work-stress-disease Associations for Cardiovascular Disease.” International Journal of Occupational Medicine and Environmental Health 23 (3): 293–312.
APA
Karasek, R., Collins, S., Clays, E., Bortkiewics, A., & Ferrario, M. (2010). Description of a large-scale study design to assess work-stress-disease associations for cardiovascular disease. INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH, 23(3), 293–312.
Vancouver
1.
Karasek R, Collins S, Clays E, Bortkiewics A, Ferrario M. Description of a large-scale study design to assess work-stress-disease associations for cardiovascular disease. INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH. 2010;23(3):293–312.
MLA
Karasek, Robert, Sean Collins, Els Clays, et al. “Description of a Large-scale Study Design to Assess Work-stress-disease Associations for Cardiovascular Disease.” INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH 23.3 (2010): 293–312. Print.