Ghent University Academic Bibliography

Advanced

Key signalling nodes in mammary gland development and cancer: the snail1-twist1 conspiracy in malignant breast cancer progression

Ellen Foubert UGent, Bram De Craene UGent and Geert Berx UGent (2010) BREAST CANCER RESEARCH. 12(3).
abstract
Breast cancer is the most common cancer among women, and despite significant advances in diagnosing and treating it, metastatic spread of cancer cells results in a high mortality rate. Epithelial-to-mesenchymal transition (EMT) is an embryonic program in which epithelial cells lose their characteristics and gain mesenchymal features. Therefore, EMT might play a very important role during malignant tumour progression. In this review we summarise recent advances in breast cancer research with a particular focus on the transcription factors Snail1 and Twist1. Besides discussing the role of EMT in normal mammary gland development, we describe regulatory mechanisms involving newly discovered upstream regulators and microRNAs, the association of EMT with breast cancer stem cells, and the involvement of the tumour micro-environment in breast cancer progression.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CELL SELF-RENEWAL, NF-KAPPA-B, EPITHELIAL-MESENCHYMAL TRANSITION, STEM-CELLS, TRANSCRIPTION FACTORS, E-CADHERIN, TUMOR INVASION, MIR-200 FAMILY, GENE-EXPRESSION, DOWN-REGULATION
journal title
BREAST CANCER RESEARCH
Breast Cancer Res.
volume
12
issue
3
article_number
206
pages
11 pages
Web of Science type
Review
Web of Science id
000285689000028
JCR category
ONCOLOGY
JCR impact factor
5.785 (2010)
JCR rank
23/181 (2010)
JCR quartile
1 (2010)
ISSN
1465-5411
DOI
10.1186/bcr2585
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1153323
handle
http://hdl.handle.net/1854/LU-1153323
date created
2011-02-16 16:47:44
date last changed
2012-06-26 14:32:14
@article{1153323,
  abstract     = {Breast cancer is the most common cancer among women, and despite significant advances in diagnosing and treating it, metastatic spread of cancer cells results in a high mortality rate. Epithelial-to-mesenchymal transition (EMT) is an embryonic program in which epithelial cells lose their characteristics and gain mesenchymal features. Therefore, EMT might play a very important role during malignant tumour progression. In this review we summarise recent advances in breast cancer research with a particular focus on the transcription factors Snail1 and Twist1. Besides discussing the role of EMT in normal mammary gland development, we describe regulatory mechanisms involving newly discovered upstream regulators and microRNAs, the association of EMT with breast cancer stem cells, and the involvement of the tumour micro-environment in breast cancer progression.},
  articleno    = {206},
  author       = {Foubert, Ellen and De Craene, Bram and Berx, Geert},
  issn         = {1465-5411},
  journal      = {BREAST CANCER RESEARCH},
  keyword      = {CELL SELF-RENEWAL,NF-KAPPA-B,EPITHELIAL-MESENCHYMAL TRANSITION,STEM-CELLS,TRANSCRIPTION FACTORS,E-CADHERIN,TUMOR INVASION,MIR-200 FAMILY,GENE-EXPRESSION,DOWN-REGULATION},
  language     = {eng},
  number       = {3},
  pages        = {11},
  title        = {Key signalling nodes in mammary gland development and cancer: the snail1-twist1 conspiracy in malignant breast cancer progression},
  url          = {http://dx.doi.org/10.1186/bcr2585},
  volume       = {12},
  year         = {2010},
}

Chicago
Foubert, Ellen, Bram De Craene, and Geert Berx. 2010. “Key Signalling Nodes in Mammary Gland Development and Cancer: The Snail1-twist1 Conspiracy in Malignant Breast Cancer Progression.” Breast Cancer Research 12 (3).
APA
Foubert, E., De Craene, B., & Berx, G. (2010). Key signalling nodes in mammary gland development and cancer: the snail1-twist1 conspiracy in malignant breast cancer progression. BREAST CANCER RESEARCH, 12(3).
Vancouver
1.
Foubert E, De Craene B, Berx G. Key signalling nodes in mammary gland development and cancer: the snail1-twist1 conspiracy in malignant breast cancer progression. BREAST CANCER RESEARCH. 2010;12(3).
MLA
Foubert, Ellen, Bram De Craene, and Geert Berx. “Key Signalling Nodes in Mammary Gland Development and Cancer: The Snail1-twist1 Conspiracy in Malignant Breast Cancer Progression.” BREAST CANCER RESEARCH 12.3 (2010): n. pag. Print.