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Widening of the spinal canal and dural ectasia in Marfan's syndrome: assessment by CT

Geert Villeirs (UGent) , Ariane Van Tongerloo (UGent) , Koenraad Verstraete (UGent) , Marc Kunnen (UGent) and Anne De Paepe (UGent)
(1999) NEURORADIOLOGY. 41(11). p.850-854
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Abstract
We describe a method for diagnosing dural ectasia (DE) and spinal canal widening (SCW) using CT. We examined 23 patients with Marfan's syndrome (MFS), 17 with Ehlers-Danlos syndrome (EDS) and 29 normal subjects, using six axial slices at the level of the L1-S1 pedicles. Transverse diameters of the vertebral bodies, spinal canal and dural sac were measured and indices were defined to differentiate patients with DE and SCW from normal. Statistical significance was assessed using Student's t-test, chi(2)-test and Pearson's correlation coefficient. DE and SCW occurred in 69.6 % and 60.9 % of cases of MFS and in 23.5 % and 35.3 % of EDS respectively. In MFS, prevalence was significantly higher than in the control group. DE was significantly more frequent in MFS than in EDS. A strong correlation existed between DE and SCW in MFS and the control group, but not in EDS. Our system enables quantitative assessment of SCW and DE. The latter is particularly important in subjects suspected of having MFS, in whom it is a common and characteristic sign.
Keywords
computed tomography, CHROMOSOME-15, Ectasia dural, spinal canal, Ehlers-Danlos syndrome, Marfan's syndrome

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Chicago
Villeirs, Geert, Ariane Van Tongerloo, Koenraad Verstraete, Marc Kunnen, and Anne De Paepe. 1999. “Widening of the Spinal Canal and Dural Ectasia in Marfan’s Syndrome: Assessment by CT.” Neuroradiology 41 (11): 850–854.
APA
Villeirs, G., Van Tongerloo, A., Verstraete, K., Kunnen, M., & De Paepe, A. (1999). Widening of the spinal canal and dural ectasia in Marfan’s syndrome: assessment by CT. NEURORADIOLOGY, 41(11), 850–854.
Vancouver
1.
Villeirs G, Van Tongerloo A, Verstraete K, Kunnen M, De Paepe A. Widening of the spinal canal and dural ectasia in Marfan’s syndrome: assessment by CT. NEURORADIOLOGY. 1999;41(11):850–4.
MLA
Villeirs, Geert, Ariane Van Tongerloo, Koenraad Verstraete, et al. “Widening of the Spinal Canal and Dural Ectasia in Marfan’s Syndrome: Assessment by CT.” NEURORADIOLOGY 41.11 (1999): 850–854. Print.
@article{115137,
  abstract     = {We describe a method for diagnosing dural ectasia (DE) and spinal canal widening (SCW) using CT. We examined 23 patients with Marfan's syndrome (MFS), 17 with Ehlers-Danlos syndrome (EDS) and 29 normal subjects, using six axial slices at the level of the L1-S1 pedicles. Transverse diameters of the vertebral bodies, spinal canal and dural sac were measured and indices were defined to differentiate patients with DE and SCW from normal. Statistical significance was assessed using Student's t-test, chi(2)-test and Pearson's correlation coefficient. DE and SCW occurred in 69.6 \% and 60.9 \% of cases of MFS and in 23.5 \% and 35.3 \% of EDS respectively. In MFS, prevalence was significantly higher than in the control group. DE was significantly more frequent in MFS than in EDS. A strong correlation existed between DE and SCW in MFS and the control group, but not in EDS. Our system enables quantitative assessment of SCW and DE. The latter is particularly important in subjects suspected of having MFS, in whom it is a common and characteristic sign.},
  author       = {Villeirs, Geert and Van Tongerloo, Ariane and Verstraete, Koenraad and Kunnen, Marc and De Paepe, Anne},
  issn         = {0028-3940},
  journal      = {NEURORADIOLOGY},
  keyword      = {computed tomography,CHROMOSOME-15,Ectasia dural,spinal canal,Ehlers-Danlos syndrome,Marfan's syndrome},
  language     = {eng},
  number       = {11},
  pages        = {850--854},
  title        = {Widening of the spinal canal and dural ectasia in Marfan's syndrome: assessment by CT},
  url          = {http://dx.doi.org/10.1007/s002340050856},
  volume       = {41},
  year         = {1999},
}

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