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Widening of the spinal canal and dural ectasia in Marfan's syndrome: assessment by CT

Geert Villeirs UGent, Ariane Van Tongerloo UGent, Koenraad Verstraete UGent, Marc Kunnen and Anne De Paepe UGent (1999) NEURORADIOLOGY. 41(11). p.850-854
abstract
We describe a method for diagnosing dural ectasia (DE) and spinal canal widening (SCW) using CT. We examined 23 patients with Marfan's syndrome (MFS), 17 with Ehlers-Danlos syndrome (EDS) and 29 normal subjects, using six axial slices at the level of the L1-S1 pedicles. Transverse diameters of the vertebral bodies, spinal canal and dural sac were measured and indices were defined to differentiate patients with DE and SCW from normal. Statistical significance was assessed using Student's t-test, chi(2)-test and Pearson's correlation coefficient. DE and SCW occurred in 69.6 % and 60.9 % of cases of MFS and in 23.5 % and 35.3 % of EDS respectively. In MFS, prevalence was significantly higher than in the control group. DE was significantly more frequent in MFS than in EDS. A strong correlation existed between DE and SCW in MFS and the control group, but not in EDS. Our system enables quantitative assessment of SCW and DE. The latter is particularly important in subjects suspected of having MFS, in whom it is a common and characteristic sign.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
computed tomography, CHROMOSOME-15, Ectasia dural, spinal canal, Ehlers-Danlos syndrome, Marfan's syndrome
journal title
NEURORADIOLOGY
Neuroradiology
volume
41
issue
11
pages
850 - 854
Web of Science type
Article
Web of Science id
000083975400011
ISSN
0028-3940
DOI
10.1007/s002340050856
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
115137
handle
http://hdl.handle.net/1854/LU-115137
date created
2004-01-14 13:35:00
date last changed
2016-12-19 15:37:24
@article{115137,
  abstract     = {We describe a method for diagnosing dural ectasia (DE) and spinal canal widening (SCW) using CT. We examined 23 patients with Marfan's syndrome (MFS), 17 with Ehlers-Danlos syndrome (EDS) and 29 normal subjects, using six axial slices at the level of the L1-S1 pedicles. Transverse diameters of the vertebral bodies, spinal canal and dural sac were measured and indices were defined to differentiate patients with DE and SCW from normal. Statistical significance was assessed using Student's t-test, chi(2)-test and Pearson's correlation coefficient. DE and SCW occurred in 69.6 \% and 60.9 \% of cases of MFS and in 23.5 \% and 35.3 \% of EDS respectively. In MFS, prevalence was significantly higher than in the control group. DE was significantly more frequent in MFS than in EDS. A strong correlation existed between DE and SCW in MFS and the control group, but not in EDS. Our system enables quantitative assessment of SCW and DE. The latter is particularly important in subjects suspected of having MFS, in whom it is a common and characteristic sign.},
  author       = {Villeirs, Geert and Van Tongerloo, Ariane and Verstraete, Koenraad and Kunnen, Marc and De Paepe, Anne},
  issn         = {0028-3940},
  journal      = {NEURORADIOLOGY},
  keyword      = {computed tomography,CHROMOSOME-15,Ectasia dural,spinal canal,Ehlers-Danlos syndrome,Marfan's syndrome},
  language     = {eng},
  number       = {11},
  pages        = {850--854},
  title        = {Widening of the spinal canal and dural ectasia in Marfan's syndrome: assessment by CT},
  url          = {http://dx.doi.org/10.1007/s002340050856},
  volume       = {41},
  year         = {1999},
}

Chicago
Villeirs, Geert, Ariane Van Tongerloo, Koenraad Verstraete, Marc Kunnen, and Anne De Paepe. 1999. “Widening of the Spinal Canal and Dural Ectasia in Marfan’s Syndrome: Assessment by CT.” Neuroradiology 41 (11): 850–854.
APA
Villeirs, G., Van Tongerloo, A., Verstraete, K., Kunnen, M., & De Paepe, A. (1999). Widening of the spinal canal and dural ectasia in Marfan’s syndrome: assessment by CT. NEURORADIOLOGY, 41(11), 850–854.
Vancouver
1.
Villeirs G, Van Tongerloo A, Verstraete K, Kunnen M, De Paepe A. Widening of the spinal canal and dural ectasia in Marfan’s syndrome: assessment by CT. NEURORADIOLOGY. 1999;41(11):850–4.
MLA
Villeirs, Geert, Ariane Van Tongerloo, Koenraad Verstraete, et al. “Widening of the Spinal Canal and Dural Ectasia in Marfan’s Syndrome: Assessment by CT.” NEURORADIOLOGY 41.11 (1999): 850–854. Print.