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Does personality disorder co-morbidity impact treatment outcome for patients with major depression? A multi-level analysis

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Abstract
In literature, there exists disagreement regarding the impact of co-morbid personality disorder(s) (PD[s]) on treatment outcome for patients with major depressive disorder (MDD). The aim of this paper was to investigate whether statistical heterogeneity and inter-dependency are potential moderators of the effect of co-morbid PDs on outcome for patients with MDD. Clinician-rated MADRS scores and DSM-IV Axis II personality disorder diagnoses were obtained from 562 outpatients with MDD who received 6 months of combined psycho- and pharmacotherapy. Single-level regression showed significantly worse treatment outcome among patients with co-morbid PD, as compared to patients with no PD. After controlling for statistical heterogeneity and interdependency, treatment outcome was no longer significantly worse for patients with co-morbid PD. In conclusion, heteroscedasticity and inter-dependency should be considered as potentially compelling explanations for inconsistencies in findings on treatment outcome for depressed patients with co-morbid PDs.
Keywords
CLUSTER, INTERPERSONAL PSYCHOTHERAPY, METAANALYSIS, PATHOLOGY

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Chicago
De Bolle, Marleen, Filip De Fruyt, Lena C Quilty, Jean-Pierre Rolland, Mieke Decuyper, and R Michael Bagby. 2011. “Does Personality Disorder Co-morbidity Impact Treatment Outcome for Patients with Major Depression? A Multi-level Analysis.” Journal of Personality Disorders 25 (1): 1–15.
APA
De Bolle, M., De Fruyt, F., Quilty, L. C., Rolland, J.-P., Decuyper, M., & Bagby, R. M. (2011). Does personality disorder co-morbidity impact treatment outcome for patients with major depression? A multi-level analysis. JOURNAL OF PERSONALITY DISORDERS, 25(1), 1–15.
Vancouver
1.
De Bolle M, De Fruyt F, Quilty LC, Rolland J-P, Decuyper M, Bagby RM. Does personality disorder co-morbidity impact treatment outcome for patients with major depression? A multi-level analysis. JOURNAL OF PERSONALITY DISORDERS. 2011;25(1):1–15.
MLA
De Bolle, Marleen, Filip De Fruyt, Lena C Quilty, et al. “Does Personality Disorder Co-morbidity Impact Treatment Outcome for Patients with Major Depression? A Multi-level Analysis.” JOURNAL OF PERSONALITY DISORDERS 25.1 (2011): 1–15. Print.
@article{1150955,
  abstract     = {In literature, there exists disagreement regarding the impact of co-morbid personality disorder(s) (PD[s]) on treatment outcome for patients with major depressive disorder (MDD). The aim of this paper was to investigate whether statistical heterogeneity and inter-dependency are potential moderators of the effect of co-morbid PDs on outcome for patients with MDD. Clinician-rated MADRS scores and DSM-IV Axis II personality disorder diagnoses were obtained from 562 outpatients with MDD who received 6 months of combined psycho- and pharmacotherapy. Single-level regression showed significantly worse treatment outcome among patients with co-morbid PD, as compared to patients with no PD. After controlling for statistical heterogeneity and interdependency, treatment outcome was no longer significantly worse for patients with co-morbid PD. In conclusion, heteroscedasticity and inter-dependency should be considered as potentially compelling explanations for inconsistencies in findings on treatment outcome for depressed patients with co-morbid PDs.},
  author       = {De Bolle, Marleen and De Fruyt, Filip and Quilty, Lena C and Rolland, Jean-Pierre and Decuyper, Mieke and Bagby, R Michael},
  issn         = {0885-579X},
  journal      = {JOURNAL OF PERSONALITY DISORDERS},
  keyword      = {CLUSTER,INTERPERSONAL PSYCHOTHERAPY,METAANALYSIS,PATHOLOGY},
  language     = {eng},
  number       = {1},
  pages        = {1--15},
  title        = {Does personality disorder co-morbidity impact treatment outcome for patients with major depression? A multi-level analysis},
  volume       = {25},
  year         = {2011},
}

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