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Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?

Wim Vanden Berghe UGent and Guy Haegeman UGent (2010) CURRENT DRUG METABOLISM. 11(5). p.436-450
abstract
While many botanicals have been used during thousands of years in various cultures for the treatment of several inflammatory conditions, wound healing or preserving skin beauty, their active ingredients and their mechanisms of action are less well characterized. It is known that throughout life, environmental conditions and dietary compounds influence gene expression. Only recently it has been observed that exposure to specific phytochemicals can affect gene expression via reversible epigenetic mechanisms and gets recorded in our "epigenome" through life. Epigenetics refers to heritable phenotypical differences or changes in gene expression that are not attributable to changes in DNA sequence, but rather depend on variations in DNA methylation, chromatin structure or microRNA profiles. As such, our dietary epigenetic imprint superposed on our genome may rewire gene expression patterns in the body and the host immune system, and protect against inflammatory disorders, cancer and ageing. This has recently launched reexploration of nutritional, botanical or phytopharmaceutical compounds for epigenetic effects to identify promising nutraceuticals or cosmeceuticals which could (re)program stem cell differentiation, wound healing, skin regeneration, tissue homeostasis, or "correct" epigenetic marks responsible for inflammatory skin disorders and ageing.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Epigenetics, TOLL-LIKE RECEPTORS, AP1, NF kappa B, Phytochemical, TRANSCRIPTION FACTORS, HISTONE MODIFICATIONS, IKK-RELATED KINASES, ABERRANT DNA METHYLATION, EMBRYONIC STEM-CELLS, Skin, Inflammation, NF-KAPPA-B, DEPENDENT GENE-EXPRESSION, TUMOR-NECROSIS-FACTOR, RNA-POLYMERASE-II, Diet
journal title
CURRENT DRUG METABOLISM
Curr. Drug Metab.
volume
11
issue
5
pages
436 - 450
Web of Science type
Review
Web of Science id
000279638600006
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
3.896 (2010)
JCR rank
43/249 (2010)
JCR quartile
1 (2010)
ISSN
1389-2002
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1150779
handle
http://hdl.handle.net/1854/LU-1150779
date created
2011-02-15 11:02:39
date last changed
2011-02-22 11:37:16
@article{1150779,
  abstract     = {While many botanicals have been used during thousands of years in various cultures for the treatment of several inflammatory conditions, wound healing or preserving skin beauty, their active ingredients and their mechanisms of action are less well characterized. It is known that throughout life, environmental conditions and dietary compounds influence gene expression. Only recently it has been observed that exposure to specific phytochemicals can affect gene expression via reversible epigenetic mechanisms and gets recorded in our {\textacutedbl}epigenome{\textacutedbl} through life. Epigenetics refers to heritable phenotypical differences or changes in gene expression that are not attributable to changes in DNA sequence, but rather depend on variations in DNA methylation, chromatin structure or microRNA profiles. As such, our dietary epigenetic imprint superposed on our genome may rewire gene expression patterns in the body and the host immune system, and protect against inflammatory disorders, cancer and ageing. This has recently launched reexploration of nutritional, botanical or phytopharmaceutical compounds for epigenetic effects to identify promising nutraceuticals or cosmeceuticals which could (re)program stem cell differentiation, wound healing, skin regeneration, tissue homeostasis, or {\textacutedbl}correct{\textacutedbl} epigenetic marks responsible for inflammatory skin disorders and ageing.},
  author       = {Vanden Berghe, Wim and Haegeman, Guy},
  issn         = {1389-2002},
  journal      = {CURRENT DRUG METABOLISM},
  keyword      = {Epigenetics,TOLL-LIKE RECEPTORS,AP1,NF kappa B,Phytochemical,TRANSCRIPTION FACTORS,HISTONE MODIFICATIONS,IKK-RELATED KINASES,ABERRANT DNA METHYLATION,EMBRYONIC STEM-CELLS,Skin,Inflammation,NF-KAPPA-B,DEPENDENT GENE-EXPRESSION,TUMOR-NECROSIS-FACTOR,RNA-POLYMERASE-II,Diet},
  language     = {eng},
  number       = {5},
  pages        = {436--450},
  title        = {Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?},
  volume       = {11},
  year         = {2010},
}

Chicago
Vanden Berghe, Wim, and Guy Haegeman. 2010. “Epigenetic Remedies by Dietary Phytochemicals Against Inflammatory Skin Disorders: Myth or Reality?” Current Drug Metabolism 11 (5): 436–450.
APA
Vanden Berghe, W., & Haegeman, G. (2010). Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality? CURRENT DRUG METABOLISM, 11(5), 436–450.
Vancouver
1.
Vanden Berghe W, Haegeman G. Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality? CURRENT DRUG METABOLISM. 2010;11(5):436–50.
MLA
Vanden Berghe, Wim, and Guy Haegeman. “Epigenetic Remedies by Dietary Phytochemicals Against Inflammatory Skin Disorders: Myth or Reality?” CURRENT DRUG METABOLISM 11.5 (2010): 436–450. Print.