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Practical and molecular evaluation of colorectal cancer new roles for the pathologist in the era of targeted therapy

Gert De Hertogh and Karen Geboes UGent (2010) ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE. 134(6). p.853-863
abstract
Context.-Colorectal cancer is the third most common cancer and the fourth most common cause of cancer death worldwide. Patient cases are discussed in multidisciplinary meetings to decide on the best management on an individual basis. Until recently, the main task of the pathologist in such teams was to provide clinically useful reports comprising staging of colorectal cancer in surgical specimens. The advent of total mesorectal excision and the application of anti-epidermal growth factor receptor (EGFR)-targeted therapies for selected patients with metastasized colorectal cancer have changed the role of the pathologist. Objectives.-To present the traditional role of the pathologist in the multidisciplinary team treating patients with colorectal cancer, to address the technique of total mesorectal excision and its implications for the evaluation of surgical specimens, to offer background information on the various EGFR-targeted therapies, and to review the currently investigated tissue biomarkers assumed to be predictive for efficacy of such therapies, with a focus on the role of the pathologist in determining the status of such biomarkers in individual tumors. Data Sources.-This article is based on selected articles pertaining to biopsy evaluation of colorectal carcinoma and reviews of EGFR-targeted therapies for this cancer. All references are accessible via the PubMed database (US National Library of Medicine and the National Institutes of Health). Conclusions.-Pathologists play an increasingly important role in the diagnosis and management of colorectal cancer because of the advent of new surgical techniques and of targeted therapies. It is expected that this role will increase further in the near future. (Arch Pathol Lab Med. 2010;134:853-863)
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TOTAL MESORECTAL EXCISION, GROWTH-FACTOR-RECEPTOR, GENE COPY NUMBER, CIRCUMFERENTIAL MARGIN INVOLVEMENT, FLUOROURACIL PLUS LEVAMISOLE, PROGRESSION-FREE-SURVIVAL, CETUXIMAB SHOWS ACTIVITY, PHASE-III TRIAL, RECTAL-CANCER, COLON-CANCER
journal title
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
Arch. Pathol. Lab. Med.
volume
134
issue
6
pages
853 - 863
Web of Science type
Article
Web of Science id
000278642000009
JCR category
MEDICAL LABORATORY TECHNOLOGY
JCR impact factor
2.279 (2010)
JCR rank
7/30 (2010)
JCR quartile
1 (2010)
ISSN
0003-9985
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1150722
handle
http://hdl.handle.net/1854/LU-1150722
date created
2011-02-15 10:54:09
date last changed
2016-12-19 15:45:24
@article{1150722,
  abstract     = {Context.-Colorectal cancer is the third most common cancer and the fourth most common cause of cancer death worldwide. Patient cases are discussed in multidisciplinary meetings to decide on the best management on an individual basis. Until recently, the main task of the pathologist in such teams was to provide clinically useful reports comprising staging of colorectal cancer in surgical specimens. The advent of total mesorectal excision and the application of anti-epidermal growth factor receptor (EGFR)-targeted therapies for selected patients with metastasized colorectal cancer have changed the role of the pathologist.
Objectives.-To present the traditional role of the pathologist in the multidisciplinary team treating patients with colorectal cancer, to address the technique of total mesorectal excision and its implications for the evaluation of surgical specimens, to offer background information on the various EGFR-targeted therapies, and to review the currently investigated tissue biomarkers assumed to be predictive for efficacy of such therapies, with a focus on the role of the pathologist in determining the status of such biomarkers in individual tumors.
Data Sources.-This article is based on selected articles pertaining to biopsy evaluation of colorectal carcinoma and reviews of EGFR-targeted therapies for this cancer. All references are accessible via the PubMed database (US National Library of Medicine and the National Institutes of Health).
Conclusions.-Pathologists play an increasingly important role in the diagnosis and management of colorectal cancer because of the advent of new surgical techniques and of targeted therapies. It is expected that this role will increase further in the near future. (Arch Pathol Lab Med. 2010;134:853-863)},
  author       = {De Hertogh, Gert and Geboes, Karen},
  issn         = {0003-9985},
  journal      = {ARCHIVES OF PATHOLOGY \& LABORATORY MEDICINE},
  keyword      = {TOTAL MESORECTAL EXCISION,GROWTH-FACTOR-RECEPTOR,GENE COPY NUMBER,CIRCUMFERENTIAL MARGIN INVOLVEMENT,FLUOROURACIL PLUS LEVAMISOLE,PROGRESSION-FREE-SURVIVAL,CETUXIMAB SHOWS ACTIVITY,PHASE-III TRIAL,RECTAL-CANCER,COLON-CANCER},
  language     = {eng},
  number       = {6},
  pages        = {853--863},
  title        = {Practical and molecular evaluation of colorectal cancer new roles for the pathologist in the era of targeted therapy},
  volume       = {134},
  year         = {2010},
}

Chicago
De Hertogh, Gert, and Karen Geboes. 2010. “Practical and Molecular Evaluation of Colorectal Cancer New Roles for the Pathologist in the Era of Targeted Therapy.” Archives of Pathology & Laboratory Medicine 134 (6): 853–863.
APA
De Hertogh, G., & Geboes, K. (2010). Practical and molecular evaluation of colorectal cancer new roles for the pathologist in the era of targeted therapy. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 134(6), 853–863.
Vancouver
1.
De Hertogh G, Geboes K. Practical and molecular evaluation of colorectal cancer new roles for the pathologist in the era of targeted therapy. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE. 2010;134(6):853–63.
MLA
De Hertogh, Gert, and Karen Geboes. “Practical and Molecular Evaluation of Colorectal Cancer New Roles for the Pathologist in the Era of Targeted Therapy.” ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 134.6 (2010): 853–863. Print.