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Clinical practice: neonatal cholestasis

(2011) EUROPEAN JOURNAL OF PEDIATRICS. 170(3). p.279-284
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Abstract
Neonatal cholestasis is a serious condition which requires urgent further investigation. Delayed referral of cholestatic neonates, however, is still a significant problem. Every child presenting with jaundice beyond the age of 2 weeks should be evaluated with a fractionated bilirubin checked. In case of neonatal cholestasis, the first step should be the assessment of coagulation and urgent parenteral vitamin K administration in case of coagulopathy and the exclusion of life-threatening conditions or disorders requiring urgent specific treatment. Any child presenting with acholic stools should be referred to a paediatric hepatology unit in order to confirm or rule out biliary atresia, as prognosis after porto-enterostomy correlates with younger age at the time of surgery. Once these conditions have been excluded, a more individualised approach is used based on anamnestic, clinical and further diagnostic findings. Besides specific medical or surgical therapy for selected diseases, early supportive treatment aiming for optimal growth and development and prevention of complications is of uttermost importance.
Keywords
INFANTS, EXTRAHEPATIC BILIARY ATRESIA, CHOLESTASIS, JAUNDICE, MECHANISMS, FOLLOW, Neonatal cholestasis, Extrahepatic biliary atresia, Conjugated hyperbilirubinaemia, Jaundice

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Citation

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Chicago
De Bruyne, Ruth, Stephanie Van Biervliet, Saskia Vande Velde, and Myriam Van Winckel. 2011. “Clinical Practice: Neonatal Cholestasis.” European Journal of Pediatrics 170 (3): 279–284.
APA
De Bruyne, R., Van Biervliet, S., Vande Velde, S., & Van Winckel, M. (2011). Clinical practice: neonatal cholestasis. EUROPEAN JOURNAL OF PEDIATRICS, 170(3), 279–284.
Vancouver
1.
De Bruyne R, Van Biervliet S, Vande Velde S, Van Winckel M. Clinical practice: neonatal cholestasis. EUROPEAN JOURNAL OF PEDIATRICS. 2011;170(3):279–84.
MLA
De Bruyne, Ruth, Stephanie Van Biervliet, Saskia Vande Velde, et al. “Clinical Practice: Neonatal Cholestasis.” EUROPEAN JOURNAL OF PEDIATRICS 170.3 (2011): 279–284. Print.
@article{1148854,
  abstract     = {Neonatal cholestasis is a serious condition which requires urgent further investigation. Delayed referral of cholestatic neonates, however, is still a significant problem. Every child presenting with jaundice beyond the age of 2 weeks should be evaluated with a fractionated bilirubin checked. In case of neonatal cholestasis, the first step should be the assessment of coagulation and urgent parenteral vitamin K administration in case of coagulopathy and the exclusion of life-threatening conditions or disorders requiring urgent specific treatment. Any child presenting with acholic stools should be referred to a paediatric hepatology unit in order to confirm or rule out biliary atresia, as prognosis after porto-enterostomy correlates with younger age at the time of surgery. Once these conditions have been excluded, a more individualised approach is used based on anamnestic, clinical and further diagnostic findings. Besides specific medical or surgical therapy for selected diseases, early supportive treatment aiming for optimal growth and development and prevention of complications is of uttermost importance.},
  author       = {De Bruyne, Ruth and Van Biervliet, Stephanie and Vande Velde, Saskia and Van Winckel, Myriam},
  issn         = {0340-6199},
  journal      = {EUROPEAN JOURNAL OF PEDIATRICS},
  keyword      = {INFANTS,EXTRAHEPATIC BILIARY ATRESIA,CHOLESTASIS,JAUNDICE,MECHANISMS,FOLLOW,Neonatal cholestasis,Extrahepatic biliary atresia,Conjugated hyperbilirubinaemia,Jaundice},
  language     = {eng},
  number       = {3},
  pages        = {279--284},
  title        = {Clinical practice: neonatal cholestasis},
  url          = {http://dx.doi.org/10.1007/s00431-010-1363-8},
  volume       = {170},
  year         = {2011},
}

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