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Colonic transit time in mentally retarded persons

SASKIA VANDE VELDE UGent, Stephanie Van Biervliet UGent, Gert Van Goethem, Danny De Looze UGent and Myriam Van Winckel UGent (2010) INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. 25(7). p.867-871
abstract
Constipation is frequently seen in patients with mental retardation (MR). Its pathophysiology is poorly understood. Measurement of colon transit time (CTT) differentiates between retentive and non-retentive constipation. To determine total and segmental CTT in MR patients compared to healthy controls. Of 250 residents, 60 patients older then 16, without swallowing disorder or scoliosis, are randomly chosen, 58 participated (intelligence quotient < 50, median age 35.5 year, 29 male). Constipation was defined as less than three defecations a week. Controls are 32 non-constipated age-matched healthy volunteers (median age 29 year, 19 male). CTT is measured by daily administration of ten radio-opaque markers during 6 days and abdominal X-ray on day 7. CTT is calculated using Bouchoucha's [7] method. Compared to controls, total CTT is significantly (P < 0.001) longer in MR (median 22.8 h vs. 57.6 h, respectively). Of the MR patients, 21/58 (36%) are constipated. The mental retardated and constipated (MRC) have a significant prolonged CTT in all segments (P < 0.01; median right CTT 19.2 h vs. 4.8 h; left CTT 14.4 h vs. 4.8 h; rectosigmoidal CTT 42 h vs. 9.6 h), whereas in mental retarded non-constipated (MRNC) persons, the rectosigmoidal CTT is prolonged (median 21.6 h vs. 9.6 h). Patients with moderate to deep MR have a significantly prolonged total CTT. In MRNC persons, rectosigmoidal CTT prolongation suggests a defecation problem. In MRC, CTT is prolonged in all segments, suggesting diffuse colonic inertia problem.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Mentally retarded, Colon transit time, Adults, Constipation, PATHOPHYSIOLOGY, DISORDERS, CONSTIPATION
journal title
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
Int. J. Colorectal Dis.
volume
25
issue
7
pages
867 - 871
Web of Science type
Article
Web of Science id
000278290600012
JCR category
SURGERY
JCR impact factor
2.645 (2010)
JCR rank
37/186 (2010)
JCR quartile
1 (2010)
ISSN
0179-1958
DOI
10.1007/s00384-010-0928-3
language
English
UGent publication?
yes
classification
A1
additional info
Subject Category: Gastroenterology & Hepatology; Surgery
copyright statement
I have transferred the copyright for this publication to the publisher
id
1147604
handle
http://hdl.handle.net/1854/LU-1147604
date created
2011-02-11 14:18:25
date last changed
2011-03-17 14:18:15
@article{1147604,
  abstract     = {Constipation is frequently seen in patients with mental retardation (MR). Its pathophysiology is poorly understood. Measurement of colon transit time (CTT) differentiates between retentive and non-retentive constipation. To determine total and segmental CTT in MR patients compared to healthy controls. Of 250 residents, 60 patients older then 16, without swallowing disorder or scoliosis, are randomly chosen, 58 participated (intelligence quotient {\textlangle} 50, median age 35.5 year, 29 male). Constipation was defined as less than three defecations a week. Controls are 32 non-constipated age-matched healthy volunteers (median age 29 year, 19 male). CTT is measured by daily administration of ten radio-opaque markers during 6 days and abdominal X-ray on day 7. CTT is calculated using Bouchoucha's [7] method. Compared to controls, total CTT is significantly (P {\textlangle} 0.001) longer in MR (median 22.8 h vs. 57.6 h, respectively). Of the MR patients, 21/58 (36\%) are constipated. The mental retardated and constipated (MRC) have a significant prolonged CTT in all segments (P {\textlangle} 0.01; median right CTT 19.2 h vs. 4.8 h; left CTT 14.4 h vs. 4.8 h; rectosigmoidal CTT 42 h vs. 9.6 h), whereas in mental retarded non-constipated (MRNC) persons, the rectosigmoidal CTT is prolonged (median 21.6 h vs. 9.6 h). Patients with moderate to deep MR have a significantly prolonged total CTT. In MRNC persons, rectosigmoidal CTT prolongation suggests a defecation problem. In MRC, CTT is prolonged in all segments, suggesting diffuse colonic inertia problem.},
  author       = {VANDE VELDE, SASKIA and Van Biervliet, Stephanie and Van Goethem, Gert and De Looze, Danny and Van Winckel, Myriam},
  issn         = {0179-1958},
  journal      = {INTERNATIONAL JOURNAL OF COLORECTAL DISEASE},
  keyword      = {Mentally retarded,Colon transit time,Adults,Constipation,PATHOPHYSIOLOGY,DISORDERS,CONSTIPATION},
  language     = {eng},
  number       = {7},
  pages        = {867--871},
  title        = {Colonic transit time in mentally retarded persons},
  url          = {http://dx.doi.org/10.1007/s00384-010-0928-3},
  volume       = {25},
  year         = {2010},
}

Chicago
Vande Velde, Saskia, Stephanie Van Biervliet, Gert Van Goethem, Danny De Looze, and Myriam Van Winckel. 2010. “Colonic Transit Time in Mentally Retarded Persons.” International Journal of Colorectal Disease 25 (7): 867–871.
APA
Vande Velde, Saskia, Van Biervliet, S., Van Goethem, G., De Looze, D., & Van Winckel, M. (2010). Colonic transit time in mentally retarded persons. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 25(7), 867–871.
Vancouver
1.
Vande Velde S, Van Biervliet S, Van Goethem G, De Looze D, Van Winckel M. Colonic transit time in mentally retarded persons. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. 2010;25(7):867–71.
MLA
Vande Velde, Saskia, Stephanie Van Biervliet, Gert Van Goethem, et al. “Colonic Transit Time in Mentally Retarded Persons.” INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 25.7 (2010): 867–871. Print.