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Microsatellite instability in Belgian sporadic colon carcinomas has no independent prognostic value in a Belgian study population

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Abstract
Pathological stage is currently the most important determinant of colorectal cancer prognosis. Hence, identification of additional prognostic markers is warranted. This study aimed to analyse the prognostic relevance of microsatellite instability (MSI) in 241 colon and 90 rectal tumours, using a mononucleotide loci multiplex PCR assay and immunohistochemistry. Thirty (12.4%) colon tumours and one rectal tumour showed MSI. Although MSI was associated with proximal location and poor differentiation, no survival benefit was observed. The prognostic value of stage and differentiation was confirmed in this study. Analysis by stage revealed a longer overall (stage II/III) and disease free survival (stage II) for patients with well differentiated tumours. In addition, age and distal localisation were related to longer overall survival in stage II tumours. In conclusion, our findings show an association of MSI in sporadic colon tumours and certain clinical features; however, they do not suggest a survival benefit for MSI tumours.

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Chicago
Deschoolmeester, Vanessa, Nancy Van Damme, Marc Baay, K Claes, Eric Van Marck, J F Baert, Wim Wuyts, et al. 2008. “Microsatellite Instability in Belgian Sporadic Colon Carcinomas Has No Independent Prognostic Value in a Belgian Study Population.” In AACR American Association for Cancer Research : Annual Meeting 2008, Abstracts.
APA
Deschoolmeester, Vanessa, Van Damme, N., Baay, M., Claes, K., Van Marck, E., Baert, J. F., Wuyts, W., et al. (2008). Microsatellite instability in Belgian sporadic colon carcinomas has no independent prognostic value in a Belgian study population. AACR American association for cancer research : annual meeting 2008, Abstracts. Presented at the AACR American Association for Cancer Research : Annual Meeting 2008.
Vancouver
1.
Deschoolmeester V, Van Damme N, Baay M, Claes K, Van Marck E, Baert JF, et al. Microsatellite instability in Belgian sporadic colon carcinomas has no independent prognostic value in a Belgian study population. AACR American association for cancer research : annual meeting 2008, Abstracts. 2008.
MLA
Deschoolmeester, Vanessa, Nancy Van Damme, Marc Baay, et al. “Microsatellite Instability in Belgian Sporadic Colon Carcinomas Has No Independent Prognostic Value in a Belgian Study Population.” AACR American Association for Cancer Research : Annual Meeting 2008, Abstracts. 2008. Print.
@inproceedings{1147602,
  abstract     = {Pathological stage is currently the most important determinant of colorectal cancer prognosis. Hence, identification of additional prognostic markers is warranted. This study aimed to analyse the prognostic relevance of microsatellite instability (MSI) in 241 colon and 90 rectal tumours, using a mononucleotide loci multiplex PCR assay and immunohistochemistry. Thirty (12.4\%) colon tumours and one rectal tumour showed MSI. Although MSI was associated with proximal location and poor differentiation, no survival benefit was observed. The prognostic value of stage and differentiation was confirmed in this study. Analysis by stage revealed a longer overall (stage II/III) and disease free survival (stage II) for patients with well differentiated tumours. In addition, age and distal localisation were related to longer overall survival in stage II tumours. In conclusion, our findings show an association of MSI in sporadic colon tumours and certain clinical features; however, they do not suggest a survival benefit for MSI tumours.},
  author       = {Deschoolmeester, Vanessa and Van Damme, Nancy and Baay, Marc and Claes, K and Van Marck, Eric and Baert, J F and Wuyts, Wim and Cabooter, M and Weyler, J and Vermeulen, Peter and Lardon, Filip and Vermorken, Jan B and Peeters, Marc},
  booktitle    = {AACR American association for cancer research : annual meeting 2008, Abstracts},
  language     = {eng},
  location     = {San Diego, CA, USA},
  title        = {Microsatellite instability in Belgian sporadic colon carcinomas has no independent prognostic value in a Belgian study population},
  year         = {2008},
}