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The development of a model to predict human dietary exposure to phthalates

Author
Organization
Abstract
Phthalates are organic lipophilic compounds which are mainly used as plasticizer to increase the flexibility of plastic polymers. Human exposure occurs mainly via food ingestion and can cause negative health effects (e.g. disruption of the endocrine system). Phthalates are not only present in food because of environmental contamination, but also as a result of migration from contact materials used during production, transport and storage. Specific migration limits for several phthalates have been formulated by the European Commission regarding their use in plastic food contact materials (Directive 2002/72/EC). However, up till now, there is no European regulation regarding limit values of phthalates in food products. In this study, a model is being developed to predict the human dietary exposure to eight phthalates (DMP, DEP, DiBP, DBP, BBP, DEHP, DCHP and DNOP). The model will include - among others - the environmental transfer into primary foods and the migration of phthalates from contact materials into foods. Concentration data of phthalates in environmental media, contact materials and food products will be obtained from own measurements (e.g. the phthalate contamination in the milk chain was examined) and from literature data or – if needed – can also be estimated by the dietary exposure model. By linking this model to national food consumption survey data, a dietary exposure assessment can be made for population groups. In a further step, the model will also be applicable to estimate the dietary exposure to other organic compounds (e.g. bisphenol A). The human risks related to the dietary exposure to phthalates can be evaluated by comparing the estimated intakes with tolerable daily intake values for phthalates. Eventually, these risk assessments can be used by the government to draw up specific regulations for limit values of phthalates in certain food products.
Keywords
environment, dietary exposure model, food contact materials, Phthalates

Citation

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Chicago
Fierens, Tine, Mirja Van Holderbeke, Christa Cornelis, Hanny Willems, Isabelle Sioen, and Stefaan De Henauw. 2011. “The Development of a Model to Predict Human Dietary Exposure to Phthalates.” In 3rd SETAC Europe Special Science Symposium : Abstract Book, 50–50. Society of Environmental Toxicology and Chemistry (SETAC).
APA
Fierens, T., Van Holderbeke, M., Cornelis, C., Willems, H., Sioen, I., & De Henauw, S. (2011). The development of a model to predict human dietary exposure to phthalates. 3rd SETAC Europe special science symposium : abstract book (pp. 50–50). Presented at the 3rd SETAC Europe Special Science Symposium : Prospective and retrospective environmental risk assessment of mixtures : moving from research to regulation, Society of Environmental Toxicology and Chemistry (SETAC).
Vancouver
1.
Fierens T, Van Holderbeke M, Cornelis C, Willems H, Sioen I, De Henauw S. The development of a model to predict human dietary exposure to phthalates. 3rd SETAC Europe special science symposium : abstract book. Society of Environmental Toxicology and Chemistry (SETAC); 2011. p. 50–50.
MLA
Fierens, Tine, Mirja Van Holderbeke, Christa Cornelis, et al. “The Development of a Model to Predict Human Dietary Exposure to Phthalates.” 3rd SETAC Europe Special Science Symposium : Abstract Book. Society of Environmental Toxicology and Chemistry (SETAC), 2011. 50–50. Print.
@inproceedings{1146620,
  abstract     = {Phthalates are organic lipophilic compounds which are mainly used as plasticizer to increase the flexibility of plastic polymers. Human exposure occurs mainly via food ingestion and can cause negative health effects (e.g. disruption of the endocrine system). Phthalates are not only present in food because of environmental contamination, but also as a result of migration from contact materials used during production, transport and storage. Specific migration limits for several phthalates have been formulated by the European Commission regarding their use in plastic food contact materials (Directive 2002/72/EC). However, up till now, there is no European regulation regarding limit values of phthalates in food products.
In this study, a model is being developed to predict the human dietary exposure to eight phthalates (DMP, DEP, DiBP, DBP, BBP, DEHP, DCHP and DNOP). The model will include - among others - the environmental transfer into primary foods and the migration of phthalates from contact materials into foods. Concentration data of phthalates in environmental media, contact materials and food products will be obtained from own measurements (e.g. the phthalate contamination in the milk chain was examined) and from literature data or -- if needed -- can also be estimated by the dietary exposure model. By linking this model to national food consumption survey data, a dietary exposure assessment can be made for population groups. In a further step, the model will also be applicable to estimate the dietary exposure to other organic compounds (e.g. bisphenol A).
The human risks related to the dietary exposure to phthalates can be evaluated by comparing the estimated intakes with tolerable daily intake values for phthalates. Eventually, these risk assessments can be used by the government to draw up specific regulations for limit values of phthalates in certain food products.},
  author       = {Fierens, Tine and Van Holderbeke, Mirja and Cornelis, Christa and Willems, Hanny and Sioen, Isabelle and De Henauw, Stefaan},
  booktitle    = {3rd SETAC Europe special science symposium : abstract book},
  keyword      = {environment,dietary exposure model,food contact materials,Phthalates},
  language     = {eng},
  location     = {Brussels, Belgium},
  pages        = {50--50},
  publisher    = {Society of Environmental Toxicology and Chemistry (SETAC)},
  title        = {The development of a model to predict human dietary exposure to phthalates},
  year         = {2011},
}