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Acetazolamide vasoreactivity in vascular dementia : a positron emission tomographic study

(1999) EUROPEAN NEUROLOGY. 41(1). p.31-36
Author
Organization
Abstract
The present study investigates the vasoreactivity of the brain in patients with large infarcts and dementia (multiinfarct dementia; MID) and in patients with microangiopathy, lacunes, white matter changes a nd dementia (lacunar dementia; LD) using positron emission tomography (PET) and (NH3)-N-13 as regional cerebral blood flow (rCBF) tracer. In the control group, an increase in rCBF ranging from 32 to 43% was found in all brain regions after intravenous acetazolamide administration. In both the MID group and the group with multiple infarcts without dementia, moderate loss of vasoreactivity was observed in the frontal, temporal and parietal cortex compared to the control values. Vasoreactivity was severely impaired in all cerebral regions of the LD group and restricted to the thalamus in the group with lacunes and white matter changes without dementia (lacunar stroke; LS), This suggests that global loss of vasoreactivity is not a determining factor in the occurrence of MID, but might be important in LD, The present study shows that loss of the vascular reserve leading to exhausted metabolic reserve of the whole brain is one of the possible mechanisms for the occurrence of vascular dementia.
Keywords
ALZHEIMERS-DISEASE, CEREBRAL BLOOD-FLOW, OXYGEN-METABOLISM, COMPUTED-TOMOGRAPHY, BINSWANGER TYPE, SPECT-FINDINGS, LEUKOARAIOSIS, PERFUSION, CRITERIA, STROKE, positron emission tomography, cerebral blood flow, acetazolamide vasoreactivity, multi-infarct dementia, lacunar dementia

Citation

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MLA
De Reuck, Jacques, et al. “Acetazolamide Vasoreactivity in Vascular Dementia : A Positron Emission Tomographic Study.” EUROPEAN NEUROLOGY, vol. 41, no. 1, 1999, pp. 31–36, doi:10.1159/000007995.
APA
De Reuck, J., Decoo, D., Hasenbroekx, M., Lamont, B., Santens, P., Goethals, P., … Lemahieu, I. (1999). Acetazolamide vasoreactivity in vascular dementia : a positron emission tomographic study. EUROPEAN NEUROLOGY, 41(1), 31–36. https://doi.org/10.1159/000007995
Chicago author-date
De Reuck, Jacques, D Decoo, Marie Hasenbroekx, B Lamont, Patrick Santens, Patrick Goethals, Karel Strijckmans, and Ignace Lemahieu. 1999. “Acetazolamide Vasoreactivity in Vascular Dementia : A Positron Emission Tomographic Study.” EUROPEAN NEUROLOGY 41 (1): 31–36. https://doi.org/10.1159/000007995.
Chicago author-date (all authors)
De Reuck, Jacques, D Decoo, Marie Hasenbroekx, B Lamont, Patrick Santens, Patrick Goethals, Karel Strijckmans, and Ignace Lemahieu. 1999. “Acetazolamide Vasoreactivity in Vascular Dementia : A Positron Emission Tomographic Study.” EUROPEAN NEUROLOGY 41 (1): 31–36. doi:10.1159/000007995.
Vancouver
1.
De Reuck J, Decoo D, Hasenbroekx M, Lamont B, Santens P, Goethals P, et al. Acetazolamide vasoreactivity in vascular dementia : a positron emission tomographic study. EUROPEAN NEUROLOGY. 1999;41(1):31–6.
IEEE
[1]
J. De Reuck et al., “Acetazolamide vasoreactivity in vascular dementia : a positron emission tomographic study,” EUROPEAN NEUROLOGY, vol. 41, no. 1, pp. 31–36, 1999.
@article{114341,
  abstract     = {{The present study investigates the vasoreactivity of the brain in patients with large infarcts and dementia (multiinfarct dementia; MID) and in patients with microangiopathy, lacunes, white matter changes a nd dementia (lacunar dementia; LD) using positron emission tomography (PET) and (NH3)-N-13 as regional cerebral blood flow (rCBF) tracer. In the control group, an increase in rCBF ranging from 32 to 43% was found in all brain regions after intravenous acetazolamide administration. In both the MID group and the group with multiple infarcts without dementia, moderate loss of vasoreactivity was observed in the frontal, temporal and parietal cortex compared to the control values. Vasoreactivity was severely impaired in all cerebral regions of the LD group and restricted to the thalamus in the group with lacunes and white matter changes without dementia (lacunar stroke; LS), This suggests that global loss of vasoreactivity is not a determining factor in the occurrence of MID, but might be important in LD, The present study shows that loss of the vascular reserve leading to exhausted metabolic reserve of the whole brain is one of the possible mechanisms for the occurrence of vascular dementia.}},
  author       = {{De Reuck, Jacques and Decoo, D and Hasenbroekx, Marie and Lamont, B and Santens, Patrick and Goethals, Patrick and Strijckmans, Karel and Lemahieu, Ignace}},
  issn         = {{0014-3022}},
  journal      = {{EUROPEAN NEUROLOGY}},
  keywords     = {{ALZHEIMERS-DISEASE,CEREBRAL BLOOD-FLOW,OXYGEN-METABOLISM,COMPUTED-TOMOGRAPHY,BINSWANGER TYPE,SPECT-FINDINGS,LEUKOARAIOSIS,PERFUSION,CRITERIA,STROKE,positron emission tomography,cerebral blood flow,acetazolamide vasoreactivity,multi-infarct dementia,lacunar dementia}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{31--36}},
  title        = {{Acetazolamide vasoreactivity in vascular dementia : a positron emission tomographic study}},
  url          = {{http://doi.org/10.1159/000007995}},
  volume       = {{41}},
  year         = {{1999}},
}

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